NexGen 7T MRI scanner for mesoscale brain imaging: Integration and Dissemination

用于中尺度脑成像的 NexGen 7T MRI 扫描仪：整合与传播

• 批准号: 10725586
• 负责人: Alexander Beckett
• 金额: $ 135.69万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10725586
• 关键词: 3-Dimensional; Acceleration; Alzheimer' s Disease; Area; BRAIN initiative; Brain; Brain imaging; COVID-19 pandemic; Cells; Collaborations; Communication; Data; Data Analyses; Development; Diffusion; Education and Outreach; Educational workshop; Engineering; Ensure; Epilepsy; Feedback; Fingerprint; Functional Magnetic Resonance Imaging; Funding; Germany; Goals; Head; Human; Human Resources; Image; Imaging Techniques; Infrastructure; Institution; International; Internet; Magnetic Resonance Imaging; Magnetism; Mental disorders; Neocortex; Neurons; Neurosciences; Neurosciences Research; Performance; Peripheral; Peripheral Nerve Stimulation; Persons; Physiologic pulse; Pilot Projects; RF coil; Reproducibility; Research; Research Personnel; Resolution; Resources; Scanning; Scientist; Signal Transduction; Speed; Structure; Synapses; System; Technology; Testing; Time; Training; Travel; United States National Institutes of Health; Work; base; brain circuitry; brain magnetic resonance imaging; brain research; computer infrastructure; connectome; data exchange; density; design; experimental study; imaging approach; improved; innovation; instrument; meetings; neocortical; nervous system disorder; neural circuit; neuroimaging; neuronal circuitry; next generation; novel; operation; outreach; prospective; recruit; symposium; temporal measurement; tool; transmission process

SUMMARY The "NexGen" 7 Tesla MRI scanner at UC Berkeley is a unique resource that we wish to make available for neuroscience collaborations across the globe. It was specifically designed for extremely high resolution structural and functional neuroimaging at the scale of cortical laminae and columnar neurocircuit organization ("meso-scale"). To achieve this, the NexGen scanner builds upon existing standard 7T scanners and integrates a number of technological advances, creating synergistic improvements and gains in speed, resolution and signal. Such advances include: currently the highest performance one-of-a-kind head-only magnetic gradient coil designed to safely create more signal at faster time scales (higher gradient amplitudes and slew rates without peripheral nerve stimulation; PNS), high-density receiver array coils (e.g. up to 128 channel receive array integrated into a 7T) that enable unprecedented spatial resolution and image-forming accelerations. As part of this collaborative endeavor, we will be creating novel advances in pulse sequences for novel neuroscientific applications imaging to take advantage of the scanner hardware’s higher performance. The scanner has been validated in reproducible mesoscale fMRI studies using GE-EPI and VASO fMRI at isotropic resolutions between 0.39 mm and 0.6 mm, that is a 4.6 to 23-fold higher volumetric resolution over typical 1 mm isotropic resolution in fMRI on conventional 7T scanners. The stronger gradients offer considerable improvements in diffusion imaging reaching higher b-values with shortened TEs. These hardware advances also enable larger areas of brain coverage, higher temporal resolutions and reduced distortions at mesoscale resolutions. Thus, with the NexGen 7T, meso-scale neuroscience experiments can be greatly expanded from traditional zoomed, small volume imaging approaches. Such a one-of-a-kind instrument has great potential to continue to advance the field and will be optimally used by a diverse group of neuroscientists and clinician scientists. Funding of the current U24 proposal would facilitate engineering and scientific personnel to support and maintain the use of the scanner; enables efficient data transfer and analysis, as well as the subject recruitment, user training and guidance of scientific collaborations nationally and internationally. While the main goal of this project is to provide an innovative resource for higher granularity in functional and structural human brain research, the research resource also holds potential for better understanding neurological diseases, such as Epilepsy, Alzheimer’s and mental disorders.

总结 加州大学伯克利分校的“NexGen”7特斯拉MRI扫描仪是一种独特的资源，我们希望为 在地球仪的神经科学合作。它是专门为极高分辨率而设计的 皮质层和柱状神经回路组织的结构和功能神经成像 （“中尺度”）。为了实现这一目标，NexGen扫描仪基于现有的标准7 T扫描仪， 整合了许多技术进步，创造了协同改进和速度增益， 分辨率和信号。这些进步包括：目前性能最高的一个一类的头只 磁梯度线圈设计用于在更快的时间尺度（更高的梯度振幅）下安全地产生更多信号 和转换速率，而没有外周神经刺激; PNS）、高密度接收器阵列线圈（例如，高达128 通道接收阵列集成到一个7 T），使前所未有的空间分辨率和成像 个加快作为这项合作奋进的一部分，我们将在脉冲序列方面取得新的进展， 对于新的神经科学应用成像，利用扫描仪硬件的更高 性能该扫描仪已在可重复的中尺度fMRI研究中使用GE-EPI进行了验证， VASO fMRI在各向同性分辨率为0.39 mm和0.6 mm之间，这是4.6至23倍的体积 在常规7 T扫描仪上的fMRI中，分辨率超过典型的1 mm各向同性分辨率。更强的梯度 在扩散成像方面提供了相当大的改进，达到了更高的b值，缩短了TE。这些 硬件的进步也使更大的大脑覆盖区域，更高的时间分辨率和减少的 中尺度分辨率的失真。因此，使用NexGen 7 T，中型神经科学实验可以 大大扩展了传统的缩放、小体积成像方法。真是独一无二 该仪器具有继续推进该领域的巨大潜力，将被不同的群体最佳使用 神经科学家和临床科学家。目前U24提案的资金将促进工程 支持和维护扫描仪的使用;实现高效的数据传输， 分析，以及受试者招募，用户培训和全国科学合作指导 和国际上。虽然这个项目的主要目标是提供一个创新的资源， 在功能和结构人脑研究的粒度，研究资源也具有潜力， 更好地了解神经系统疾病，如癫痫，阿尔茨海默氏症和精神障碍。