NAMPT regulation of fracture tissue metabolism during bone healing

这一建议将优化NAD在骨折组织代谢中的功能，以增强 肥胖症/2型糖尿病患者的骨折修复，这是一种常见的情况 这种情况在退伍军人中更为常见。众所周知，2型糖尿病患者患有 由于对组织修复要求的新陈代谢反应不足而导致的骨骼愈合受损。在……里面 本研究将在小鼠诱导肥胖/2型糖尿病的条件下，局部氧化还原电位 骨折组织通过NAMPT功能的增强而得到改善。选定的激动剂 NAMPT将在骨膜细胞中进行筛选，治疗候选药物局部应用于 肥胖/2型糖尿病小鼠骨折组织及骨折愈合评价。该计划的完成 拟议的研究应该有助于开发新的治疗干预措施，以改善组织 对伤口修复的新陈代谢要求的反应。

This proposal will optimize NAD functions in the metabolism of fracture tissues for the enhancement of bone fracture repair in an obesity/Type-2 diabetic condition, a condition that is common in the general population and even more frequent among veterans. It is well established that Type-2 diabetics suffer from impaired bone healing caused by an insufficient metabolic response to the requirements of tissue repair. In this study, an obesity/Type-2 diabetes condition will be induced in mice and the redox potential of local tissues improved through the augmentation of NAMPT functions in the fracture tissues. Selected agonists of NAMPT will be screened for their effects in periosteal cells, therapeutic candidates locally applied to the fracture tissues in obesity/Type-2 diabetic mice and fracture healing evaluated. The completion of the proposed studies should facilitate the development of novel therapeutic interventions that improve tissue responses to the metabolic requirements of wound repair.