Localization of adenosine to promote fracture healing
腺苷定位促进骨折愈合
基本信息
- 批准号:10700832
- 负责人:
- 金额:$ 51.85万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-15 至 2027-05-31
- 项目状态:未结题
- 来源:
- 关键词:ADORA2A geneAccelerationAcidsAddressAdenosineAdjuvantAgeAgingAnimalsBMP2 geneBehaviorBiocompatible MaterialsBone DiseasesBone InjuryBone RegenerationBone TissueBone TransplantationBone callusCD8-Positive T-LymphocytesCellsCirculationClinicalCyclic AMPDefectDevelopmentDoseEconomic BurdenElderlyEnvironmentFemurFlow CytometryFractureFunctional disorderGaitGelGene ExpressionHalf-LifeHistologicHyaluronic AcidImmuneImmune responseImpaired healingImplantIn SituInjectableInjuryKnock-outLiteratureMacrophageMatrix MetalloproteinasesMechanicsModelingMusNatural regenerationNatureOsteogenesisOsteoporosisPatientsPhosphorylationPlasmaPlayPopulationPrevalencePublic HealthPurinergic P1 ReceptorsQuality of lifeReceptor SignalingRegulatory T-LymphocyteRejuvenationResearchRoleSignal TransductionSiteSortingT-LymphocyteTestingTherapeuticTibial FracturesTissuesTraumaVascularizationWild Type Mouseactive lifestyleage relatedagedangiogenesisbonebone agingbone fracture repairbone healingbone healthbone qualitycostcost effectivecrosslinkcytokineefficacy evaluationextracellularfragility fracturehealingimmunoregulationimprovedjuvenile animallaser capture microdissectionlongitudinal analysisneutrophilnovel therapeutic interventionolder patientperipheral bloodregenerativerepairedscaffoldsexsingle-cell RNA sequencingspatiotemporalsuccesstissue regenerationtissue repair
项目摘要
ABSTRACT
Bone fracture is a very common injury, and there has been a dramatic increase in trauma-induced fractures with
the increase in active lifestyle. Despite the regenerative ability of bone, bone injuries often suffer from delayed
healing or non-unions. The prevalence of bone fracture and the cost of repair is on the rise primarily due to aging
of the population. The profound negative impact on the patient’s quality of life and the economic burden of
fracture treatment following trauma or age-related fragility fractures warrants the development of efficient and
cost-effective fracture-healing adjuvants to accelerate the healing rate and improve the quality of healing. The
proposed research focuses on biomaterial-assisted local delivery of adenosine to promote bone healing of aged
bone tissues by rejuvenating the endogenous tissue environment and reparative cells. We hypothesize that local
delivery of adenosine at the injury site will induce a pro-regenerative immune environment and promote
regeneration of aging bone tissues through enhanced osteoblastogenesis and angiogenesis. These hypotheses
will be tested through the following aims. Aim 1 will determine the effect of local delivery of adenosine to promote
bone regeneration in aged mice by using two injury models: transverse tibial fracture and critical-sized segmental
femoral defect. Aim 2 will determine the role of adenosine delivery on immunomodulation leading to enhanced
bone regeneration. Successful completion of the proposed studies will have a significant impact in public health
by establishing a new therapeutic intervention for promoting bone regeneration.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Shyni Varghese其他文献
Shyni Varghese的其他文献
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{{ truncateString('Shyni Varghese', 18)}}的其他基金
Molecular engineering of HA-based lubricants for articular cartilage
用于关节软骨的 HA 基润滑剂的分子工程
- 批准号:
10712721 - 财政年份:2023
- 资助金额:
$ 51.85万 - 项目类别:
Localization of adenosine to promote fracture healing
腺苷定位促进骨折愈合
- 批准号:
10461465 - 财政年份:2022
- 资助金额:
$ 51.85万 - 项目类别:
Modulation of local adenosine signaling to attenuate fracture pain
调节局部腺苷信号传导以减轻骨折疼痛
- 批准号:
10543700 - 财政年份:2021
- 资助金额:
$ 51.85万 - 项目类别:
Modulation of local adenosine signaling to attenuate fracture pain
调节局部腺苷信号传导以减轻骨折疼痛
- 批准号:
10390489 - 财政年份:2021
- 资助金额:
$ 51.85万 - 项目类别:
Modulation of local adenosine signaling to attenuate fracture pain
调节局部腺苷信号传导以减轻骨折疼痛
- 批准号:
10614931 - 财政年份:2021
- 资助金额:
$ 51.85万 - 项目类别:
Modulation of local adenosine signaling to attenuate fracture pain
调节局部腺苷信号传导以减轻骨折疼痛
- 批准号:
10227375 - 财政年份:2021
- 资助金额:
$ 51.85万 - 项目类别:
Modulation of local adenosine signaling to attenuate fracture pain
调节局部腺苷信号传导以减轻骨折疼痛
- 批准号:
10812649 - 财政年份:2021
- 资助金额:
$ 51.85万 - 项目类别:
Bioinspired Synthetic Grafts for Bone Regeneration
用于骨再生的仿生合成移植物
- 批准号:
9551215 - 财政年份:2017
- 资助金额:
$ 51.85万 - 项目类别:
Adenosine A2B Receptor in Bone Health and Osteoporosis
腺苷 A2B 受体在骨骼健康和骨质疏松症中的作用
- 批准号:
9551206 - 财政年份:2017
- 资助金额:
$ 51.85万 - 项目类别:
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