Definition and Caregiver Appraisal of Paradoxical Lucidity in Dementia

项目总结 阿尔茨海默病和相关痴呆症通常被认为是进行性认知能力下降， 对于痴呆症患者出现的清醒状态，人们知之甚少。自相矛盾 清醒的定义是痴呆症患者自发的、相关的交流或联系。一些 研究主要集中在自相矛盾的清醒发作上，对可能导致自相矛盾的原因知之甚少。 清醒，清醒事件有多常见，以及清醒对痴呆症患者的家庭照顾者有多大影响。 这项研究的广泛目标是定义自相矛盾的清醒，确定高血压的患病率和预测因素 矛盾的清醒，并评估清醒对家庭照顾者的影响。我们的建议将建立一个 基于调查数据和对照顾者的访谈以及来自 阿尔茨海默病和相关痴呆症临床专家小组。接下来，我们将管理一个在线 在三个时间段(基线、6个月和12个月)对8000名痴呆症照顾者进行的调查 衡量一段时间内矛盾的清醒出现的频率。我们将分析调查数据以确定 可能预示着矛盾的清醒，以及矛盾的清醒如何与照顾者的幸福联系在一起。结果是 这项工作将有助于为临床实践提供信息，建设阿尔茨海默病教育和宣传的能力，以及 建立关于痴呆症研究不足的方面的知识。

PROJECT SUMMARY Alzheimer’s disease and related dementias are typically thought of in terms of progressive cognitive decline, and relatively little is known about episodes of lucidity that occur among people with dementia. Paradoxical lucidity is defined as spontaneous, relevant communication or connectedness in a person with dementia. Few studies have focused on paradoxical lucid episodes, and little is known about what may cause paradoxical lucidity, how common lucid events are, and how lucidity impacts family caregivers of persons with dementia. The broad goal of this study is to define paradoxical lucidity, determine the prevalence and predictors of paradoxical lucidity, and assess the impact that lucidity has on family caregivers. Our proposal will establish a definition of paradoxical lucidity based on survey data and interviews with caregivers, as well as input from a panel of clinical experts in Alzheimer’s disease and related dementias. Next, we will administer an online survey to 8,000 dementia caregivers across three time periods (baseline, 6-months, and 12-months) to measure how frequently paradoxical lucidity occurs across time. We will analyze survey data to establish what may predict paradoxical lucidity and how paradoxical lucidity is linked to caregiver well-being. The results of this work will help inform clinical practice, build capacity for Alzheimer’s Disease education and advocacy, and build knowledge on an understudied aspect of dementia.