Definition and Caregiver Appraisal of Paradoxical Lucidity in Dementia

项目摘要 阿尔茨海默病和相关痴呆症通常被认为是进行性认知衰退， 而对于痴呆症患者的清醒期，我们所知相对较少。矛盾 清醒被定义为患有痴呆症的人的自发的、相关的交流或连通性。几 研究集中在矛盾的清醒发作，很少有人知道什么可能导致矛盾的 清醒，清醒事件有多常见，以及清醒如何影响痴呆症患者的家庭照顾者。 本研究的主要目标是定义矛盾清醒，确定其患病率和预测因素， 矛盾的清醒，并评估清醒对家庭照顾者的影响。我们的建议将建立一个 根据调查数据和对照顾者的采访，以及来自一个 阿尔茨海默病和相关痴呆症的临床专家小组。接下来，我们将管理在线 在三个时间段（基线、6个月和12个月）对8，000名痴呆症护理人员进行调查， 测量一段时间内出现矛盾清醒的频率。我们将分析调查数据， 可以预测矛盾的清醒和矛盾的清醒是如何与照顾者的幸福。的结果 这项工作将有助于为临床实践提供信息，建立阿尔茨海默病教育和宣传的能力， 建立对痴呆症未充分研究方面的知识。

PROJECT SUMMARY Alzheimer’s disease and related dementias are typically thought of in terms of progressive cognitive decline, and relatively little is known about episodes of lucidity that occur among people with dementia. Paradoxical lucidity is defined as spontaneous, relevant communication or connectedness in a person with dementia. Few studies have focused on paradoxical lucid episodes, and little is known about what may cause paradoxical lucidity, how common lucid events are, and how lucidity impacts family caregivers of persons with dementia. The broad goal of this study is to define paradoxical lucidity, determine the prevalence and predictors of paradoxical lucidity, and assess the impact that lucidity has on family caregivers. Our proposal will establish a definition of paradoxical lucidity based on survey data and interviews with caregivers, as well as input from a panel of clinical experts in Alzheimer’s disease and related dementias. Next, we will administer an online survey to 8,000 dementia caregivers across three time periods (baseline, 6-months, and 12-months) to measure how frequently paradoxical lucidity occurs across time. We will analyze survey data to establish what may predict paradoxical lucidity and how paradoxical lucidity is linked to caregiver well-being. The results of this work will help inform clinical practice, build capacity for Alzheimer’s Disease education and advocacy, and build knowledge on an understudied aspect of dementia.