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Urology Centers Program Interactions Core (U24)

泌尿中心计划互动核心 (U24)

基本信息

批准号：
10700949
负责人：
Kristina L Penniston
金额：
$ 75万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-17 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10700949
关键词：
Acceleration Address American Area Award Basic Science Benign Bladder Bladder Calculi Categories Cellular biology Clinical Clinical Treatment Clinical Trials Collaborations Communication Communities Detection Development Diagnostic tests Disease Disease Management Disease Progression Education Effectiveness Environment Environmental Impact Environmental Risk Factor Etiology Evaluation Fostering Functional disorder Funding Funding Opportunities Future Genetic Genetic Predisposition to Disease Genitourinary system Goals Health Home Human Resources Incontinence Individual Infection Infrastructure Interdisciplinary Study Kidney Kidney Calculi Knowledge Leadership Link Logistics Measures Mental disorders Mentored Clinical Scientist Development Program Mentors Metabolic Methodology Mission Modeling National Institute of Diabetes and Digestive and Kidney Diseases Nature Neurogenic Bladder Outcome Pain Patient-Focused Outcomes Patients Performance Persons Phenotype Physiological Physiology Population Positioning Attribute Prevention Principal Investigator Process Productivity Program Development Program Evaluation Prostatic Public Health Quality of life Research Research Personnel Research Proposals Resource Sharing Resources Risk Science Scientist Societies Symptoms System Teleconferences Training Translational Research Universities Ureter Urethra Urinary tract Urinary tract infection Urogenital Diseases Urologic Diseases Urology Wisconsin Work care outcomes career development community building comorbidity cost diagnostic criteria effective intervention effective therapy efficacy evaluation epidemiology study evidence base experience health care delivery health care disparity improved innovation interdisciplinary approach leadership development lower urinary tract symptoms male medical schools meetings member multidisciplinary outcome disparities outreach prevent programs reproductive organ reproductive system disorder success urologic virtual web site

项目摘要

PROJECT SUMMARY The critical need remains to advance our understanding of benign genitourinary (GU) diseases – their etiology, pathophysiology, and mechanisms of progression. The phenotypic expressions of many common benign GU diseases are yet to be defined. Clinical gaps in knowledge include objective diagnostic tests and criteria for many symptomatic benign GU conditions and the efficacy of multidisciplinary and interdisciplinary approaches to management. The impact of these conditions on other disease processes and whole body health; productivity, functioning, and quality of life; and public health overall is virtually unknown. The impact of disparities in healthcare and health outcomes on patients with benign GU disease is understudied. The potential power of prevention is unexplored. The proposed Interactions Core for the Community of NIDDK-funded benign GU Centers and Programs known as CAIRIBU (Collaborating for the Advancement of Interdisciplinary Research in Benign Urology) will foster and support integrated basic and translational science that answers critical questions in benign GU disease and builds the breadth and depth of benign urologic investigators. Our mission is to provide intellectual leadership and logistic support for the CAIRIBU Community by identifying and facilitating opportunities for cross-CAIRIBU collaboration and promoting research findings and resources to the broader benign GU research community. Specific Aims are to: 1) provide scientific leadership to the CAIRIBU Community by enabling the full potential of NIDDK staff and CAIRIBU leaders to provide guidance that results in highly meritorious convergent research and highly-trained new investigators in benign GU diseases; 2) provide leadership in team science by identifying and fostering opportunities for transdisciplinary interaction and collaboration within CAIRIBU and among the broader benign GU research community; 3) provide administrative support by building the CAIRIBU infrastructure to maximize communication, collaboration, coordination, and resource sharing; and 4) develop internal and external evaluation mechanisms to maximize the performance, transdisciplinary nature, productivity, and effectiveness of the Interactions Core and CAIRIBU Community. Our Interactions Core is led by a Principal Investigator who is an established benign GU disease investigator and has functioned in a pilot capacity as Director of Interactions for CAIRIBU since July 2018. Our Co-Investigator is an expert in the science of team science and has experience in collaboration-building and measuring collaborative science efforts. The University of Wisconsin School of Medicine and Public Health provides the ideal environment for supporting the Interactions Core due to its multiple resources. The Department of Urology is the idea “home” for the Interactions Core due to its strong commitment to and track record in benign GU research. Our Core will use innovative approaches to leverage CAIRIBU members’ common passion for addressing critical gaps in knowledge in benign GU disease.

项目总结迫切需要提高我们对良性泌尿生殖系统(GU)疾病的理解--它们的病因学，病理生理学和进展机制。多种常见良性骨肉瘤的表型表达疾病的定义尚未确定。临床知识方面的差距包括客观的诊断测试和许多症状性良性胃溃疡与多学科和跨学科方法的疗效管理层。这些情况对其他疾病进程和全身健康的影响；生产力，功能和生活质量；公共卫生总体上几乎是未知的。贫富差距的影响良性胃肠道疾病患者的医疗保健和健康结局尚未得到充分研究。网络的潜在力量预防措施尚未得到探索。NIDDK资助的良性GU社区建议的交互核心称为CAIRIBU(协作促进跨学科研究)的中心和计划良性泌尿外科)将促进和支持综合的基础科学和翻译科学，以回答关键问题并建立了良性泌尿系疾病研究的广度和深度。我们的使命是提供通过识别和促进为CAIRIBU社区提供智力领导和后勤支持跨CAIRIBU合作的机会，并向更广泛的人推广研究成果和资源良性谷研究社区。具体目标是：1)为CAIRIBU社区提供科学领导通过使NIDDK员工和CAIRIBU领导的全部潜力能够提供指导，从而产生高度在良性胃肠道疾病方面卓有成效的趋同研究和训练有素的新研究人员；2)提供通过识别和培养跨学科互动的机会和在CAIRIBU内部和更广泛的良性GU研究社区之间进行协作；3)提供管理通过构建CAIRIBU基础设施提供支持，以最大限度地提高沟通、协作、协调和资源共享；以及4)建立内部和外部评估机制，以最大限度地提高绩效，互动核心和CAIRIBU社区的跨学科性质、生产力和有效性。我们的 Interaction Core由一名首席调查员领导，他是一名公认的良性胃肠道疾病调查员，自2018年7月以来一直以试点身份担任CAIRIBU的互动主任。我们的联合调查员是团队科学方面的专家，在协作建立和测量方面有经验合作的科学努力。威斯康星大学医学和公共卫生学院提供支持交互的理想环境核心由于其多个资源。泌尿外科互动的理念是不是因为它对良性GU的坚定承诺和记录而成为核心研究。我们的核心将使用创新的方法来利用CAIRIBU成员的共同热情解决良性胃肠道疾病知识方面的严重差距。