Urology Centers Program Interactions Core (U24)

项目摘要 迫切需要提高我们对良性泌尿生殖系统（GU）疾病的认识--它们的病因， 病理生理学和进展机制。多种常见良性GU的表型表达 疾病还有待确定。临床知识的差距包括客观的诊断测试和标准，许多 症状良性GU条件和多学科和跨学科方法的疗效， 管理这些条件对其他疾病过程和全身健康的影响;生产力， 功能和生活质量;和公共卫生总体上几乎是未知的。差距的影响 良性GU疾病患者的医疗保健和健康结果尚未得到充分研究。的潜在力量 预防措施尚未探索。NIDDK资助的良性GU社区的拟议互动核心 中心和项目被称为CAIRIBU（合作促进跨学科研究， 良性泌尿外科）将促进和支持综合基础和转化科学，回答关键问题 在良性GU疾病和良性泌尿外科调查的广度和深度。我们的使命是 通过识别和促进CAIRIBU社区的知识领导和后勤支持 跨CAIRIBU合作的机会，并促进研究成果和资源，以更广泛的 良性的GU研究社区。具体目标是：1）为CAIRIBU社区提供科学领导 通过充分发挥NIDDK工作人员和CAIRIBU领导人的潜力，提供指导， 在良性GU疾病方面有价值的聚合研究和训练有素的新研究人员; 2）提供 通过识别和培养跨学科互动的机会，领导团队科学， CAIRIBU内部和更广泛的良性GU研究社区之间的合作; 3）提供行政管理 通过建立CAIRIBU基础设施来支持，以最大限度地提高沟通，协作，协调和 资源共享; 4）建立内部和外部评估机制，以最大限度地提高绩效， 互动核心和CAIRIBU社区的跨学科性质、生产力和有效性。我们 Interactions Core由一名主要研究者领导，该研究者是一名公认的良性GU疾病研究者， 自2018年7月以来，他一直担任CAIRIBU互动主任的试点工作。我们的合作研究者是 团队科学方面的专家，在合作建设和衡量方面有经验 科学合作的努力。威斯康星州大学医学与公共卫生学院提供 由于其多种资源，是支持交互核心的理想环境。泌尿外科 由于其对良性GU的坚定承诺和良好记录， research.我们的核心将使用创新的方法来利用CAIRIBU成员的共同热情， 解决良性GU疾病知识的关键差距。

PROJECT SUMMARY The critical need remains to advance our understanding of benign genitourinary (GU) diseases – their etiology, pathophysiology, and mechanisms of progression. The phenotypic expressions of many common benign GU diseases are yet to be defined. Clinical gaps in knowledge include objective diagnostic tests and criteria for many symptomatic benign GU conditions and the efficacy of multidisciplinary and interdisciplinary approaches to management. The impact of these conditions on other disease processes and whole body health; productivity, functioning, and quality of life; and public health overall is virtually unknown. The impact of disparities in healthcare and health outcomes on patients with benign GU disease is understudied. The potential power of prevention is unexplored. The proposed Interactions Core for the Community of NIDDK-funded benign GU Centers and Programs known as CAIRIBU (Collaborating for the Advancement of Interdisciplinary Research in Benign Urology) will foster and support integrated basic and translational science that answers critical questions in benign GU disease and builds the breadth and depth of benign urologic investigators. Our mission is to provide intellectual leadership and logistic support for the CAIRIBU Community by identifying and facilitating opportunities for cross-CAIRIBU collaboration and promoting research findings and resources to the broader benign GU research community. Specific Aims are to: 1) provide scientific leadership to the CAIRIBU Community by enabling the full potential of NIDDK staff and CAIRIBU leaders to provide guidance that results in highly meritorious convergent research and highly-trained new investigators in benign GU diseases; 2) provide leadership in team science by identifying and fostering opportunities for transdisciplinary interaction and collaboration within CAIRIBU and among the broader benign GU research community; 3) provide administrative support by building the CAIRIBU infrastructure to maximize communication, collaboration, coordination, and resource sharing; and 4) develop internal and external evaluation mechanisms to maximize the performance, transdisciplinary nature, productivity, and effectiveness of the Interactions Core and CAIRIBU Community. Our Interactions Core is led by a Principal Investigator who is an established benign GU disease investigator and has functioned in a pilot capacity as Director of Interactions for CAIRIBU since July 2018. Our Co-Investigator is an expert in the science of team science and has experience in collaboration-building and measuring collaborative science efforts. The University of Wisconsin School of Medicine and Public Health provides the ideal environment for supporting the Interactions Core due to its multiple resources. The Department of Urology is the idea “home” for the Interactions Core due to its strong commitment to and track record in benign GU research. Our Core will use innovative approaches to leverage CAIRIBU members’ common passion for addressing critical gaps in knowledge in benign GU disease.