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Urology Centers Program Interactions Core (U24)

泌尿中心计划互动核心 (U24)

基本信息

批准号：
10264946
负责人：
Kristina L Penniston
金额：
$ 75万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-17 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10264946
关键词：
Address American Area Award Basic Science Benign Bladder Bladder Calculi Categories Cellular biology Clinical Clinical Treatment Clinical Trials Collaborations Communication Communities Congenital Abnormality Coordination and Collaboration Detection Development Diagnostic Diagnostic tests Disease Disease Management Disease Progression Effectiveness Environment Environmental Impact Environmental Risk Factor Etiology Evaluation Fostering Functional disorder Funding Funding Opportunities Future Genetic Genitourinary system Goals Health Home Human Resources Incontinence Individual Infection Infrastructure Interdisciplinary Study Kidney Kidney Calculi Knowledge Leadership Link Logistics Measures Mental disorders Mentors Metabolic Methodology Mission Modeling National Institute of Diabetes and Digestive and Kidney Diseases Nature Neurogenic Bladder Outcome Pain Patient-Focused Outcomes Patients Performance Persons Phenotype Physiological Physiology Population Positioning Attribute Prevention Principal Investigator Process Productivity Program Development Program Evaluation Prostatic Public Health Quality of life Research Research Personnel Research Proposals Resource Sharing Resources Risk SECTM1 gene Science Scientist Societies Symptoms System Teleconferences Testing Training Translational Research Universities Ureter Urethra Urinary tract Urinary tract infection Urogenital Diseases Urologic Diseases Urology Wisconsin Work care outcomes career development community building comorbidity cost effective intervention effective therapy efficacy evaluation epidemiology study evidence base experience health care delivery health care disparity improved innovation interdisciplinary approach leadership development lower urinary tract symptoms male medical schools meetings member multidisciplinary outreach prevent programs reproductive organ reproductive system disorder success urologic virtual web site

项目摘要

PROJECT SUMMARY The critical need remains to advance our understanding of benign genitourinary (GU) diseases – their etiology, pathophysiology, and mechanisms of progression. The phenotypic expressions of many common benign GU diseases are yet to be defined. Clinical gaps in knowledge include objective diagnostic tests and criteria for many symptomatic benign GU conditions and the efficacy of multidisciplinary and interdisciplinary approaches to management. The impact of these conditions on other disease processes and whole body health; productivity, functioning, and quality of life; and public health overall is virtually unknown. The impact of disparities in healthcare and health outcomes on patients with benign GU disease is understudied. The potential power of prevention is unexplored. The proposed Interactions Core for the Community of NIDDK-funded benign GU Centers and Programs known as CAIRIBU (Collaborating for the Advancement of Interdisciplinary Research in Benign Urology) will foster and support integrated basic and translational science that answers critical questions in benign GU disease and builds the breadth and depth of benign urologic investigators. Our mission is to provide intellectual leadership and logistic support for the CAIRIBU Community by identifying and facilitating opportunities for cross-CAIRIBU collaboration and promoting research findings and resources to the broader benign GU research community. Specific Aims are to: 1) provide scientific leadership to the CAIRIBU Community by enabling the full potential of NIDDK staff and CAIRIBU leaders to provide guidance that results in highly meritorious convergent research and highly-trained new investigators in benign GU diseases; 2) provide leadership in team science by identifying and fostering opportunities for transdisciplinary interaction and collaboration within CAIRIBU and among the broader benign GU research community; 3) provide administrative support by building the CAIRIBU infrastructure to maximize communication, collaboration, coordination, and resource sharing; and 4) develop internal and external evaluation mechanisms to maximize the performance, transdisciplinary nature, productivity, and effectiveness of the Interactions Core and CAIRIBU Community. Our Interactions Core is led by a Principal Investigator who is an established benign GU disease investigator and has functioned in a pilot capacity as Director of Interactions for CAIRIBU since July 2018. Our Co-Investigator is an expert in the science of team science and has experience in collaboration-building and measuring collaborative science efforts. The University of Wisconsin School of Medicine and Public Health provides the ideal environment for supporting the Interactions Core due to its multiple resources. The Department of Urology is the idea “home” for the Interactions Core due to its strong commitment to and track record in benign GU research. Our Core will use innovative approaches to leverage CAIRIBU members’ common passion for addressing critical gaps in knowledge in benign GU disease.

项目总结