A Follow-up Study for Causes of Cancer in Black Women

黑人女性癌症病因的后续研究

基本信息

  • 批准号:
    10701009
  • 负责人:
  • 金额:
    $ 204.28万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-09-21 至 2027-08-31
  • 项目状态:
    未结题

项目摘要

Pervasive health disparities affecting U.S. Black women are now widely recognized, but large gaps in knowledge remain. We began the Black Women’s Health Study (BWHS) in 1995 to identify reasons for disparities, including cancer health disparities; at that time Black women represented a very small proportion of participants in observational cohort studies. We enrolled 59,000 participants over an 8-month period in 1995 via a lengthy mail questionnaire. Subsequently, participants were asked to complete follow-up questionnaires, usually four pages in length, every two years, either on paper or online. In the most recent questionnaire cycle, responses were split equally between the two methods. Over 51,000 participants are still alive and response rates continue to be good. Among approximately 48,000 who were sent a 2019/20 questionnaire, 71% completed it and 79% responded to either that questionnaire or the prior one. Saliva samples as a source of germline and microbial DNA have been obtained and stored for 27,800 participants and blood samples for 13,030 participants. Breast tumor samples have been obtained for over 1,000 breast cancer cases; tumor tissue collection was begun in the most recent funding period for four other cancers. BWHS research covers the spectrum from individual behaviors, medication use, and other characteristics, to psychosocial factors, genetic factors, and neighborhood-level factors. Peer-reviewed publications have addressed a range of health conditions: cancers that include breast, lung, ovarian, colorectal, endometrial, pancreatic, liver, and multiple myeloma; type 2 diabetes; obesity; lupus; sarcoidosis; preterm birth; infertility; uterine leiomyoma; cognitive decline; sleep disorders; hypertension; COVID-19 infection; and mortality. More than half of current participants are under age 64, affording the potential for additional research on cancer etiology, including with collection of new or repeated exposures and covariates. During the next funding period, we expect to produce impactful findings with regard to risk of multiple myeloma and colorectal, lung, and pancreatic cancer; breast and colorectal cancer survivorship; cognitive decline and Alzheimer’s disease; end-stage renal disease; and other conditions, such as COVID-19, that disproportionately affect Black women. (According to the National Death Index (NDI), over 100 BWHS participants died from COVID-19 infection in 2020.) To reduce costs, we will reduce the frequency of questionnaires while still linking to NDI, Medicare, and cancer registries to identify and confirm new cancers, other illnesses, and deaths. We will continue to share BWHS data and samples with outside investigators, and underrepresented minority investigators in particular, and will modernize our website and data sharing systems to increase accessibility. Continued follow-up of this landmark study is critical to inform opportunities for risk reduction in a vulnerable population and to close the gap in racial disparities in cancer and other illnesses.
影响美国黑人女性的普遍健康差距现在得到了广泛承认,但在 知识留了下来。我们在1995年开始了黑人妇女健康研究(BWHS),以确定原因 差异,包括癌症健康差异;当时黑人妇女只占很小的比例 观察性队列研究的参与者。1995年,我们在8个月的时间里招募了59,000名参与者 通过一份冗长的邮寄问卷。随后,参与者被要求完成后续调查问卷, 通常是四页,每两年一次,无论是纸质的还是在线的。在最近的调查问卷周期中, 这两种方法的回答各占一半。超过51,000名参与者仍然活着,并做出了回应 利率继续保持良好。在收到2019/20年度调查问卷的约48,000人中,71% 完成了调查,79%的人回答了那份问卷或前一份问卷。唾液样本作为 已为27,800名参与者获取和存储了生殖系和微生物DNA,并为 13,030名参与者。已为1000多例乳腺癌病例采集了乳腺肿瘤样本; 组织收集是在最近的资助期间开始的,用于治疗其他四种癌症。BWHS研究涵盖 从个人行为、用药和其他特征,到心理社会因素, 遗传因素和邻里层面的因素。同行评议的出版物讨论了一系列健康问题 癌症:包括乳腺癌、肺癌、卵巢癌、结直肠癌、子宫内膜癌、胰腺癌、肝癌和多发性 骨髓瘤;2型糖尿病;肥胖;狼疮;结节病;早产;不孕症;子宫肌瘤;认知 衰弱;睡眠障碍;高血压;新冠肺炎感染;和死亡率。超过一半的当前参与者 未成年的,为癌症病因学的进一步研究提供了潜力,包括收集 新的或重复的暴露和协变量。在下一个资金期,我们预计将产生 关于多发性骨髓瘤和结直肠癌、肺癌和胰腺癌风险的研究结果;乳腺癌和 结直肠癌存活率;认知功能减退和阿尔茨海默病;终末期肾病;以及其他 像新冠肺炎这样的疾病,对黑人女性的影响不成比例。(据《国家死亡》报道) (根据国家发展指数,2020年有100多名BWHS参与者死于新冠肺炎感染。)为了降低成本,我们将 减少调查问卷的频率,同时仍与NDI、Medicare和癌症登记机构链接,以识别和 确认新的癌症、其他疾病和死亡。我们将继续与BWHS分享数据和样本 外部调查人员,特别是代表性不足的少数族裔调查人员,并将使我们的网站现代化 和数据共享系统,以提高可访问性。这项具有里程碑意义的研究的持续后续行动对 为弱势群体提供减少风险的机会,缩小#年种族差距的差距 癌症和其他疾病。

项目成果

期刊论文数量(20)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Night Shift Work and Fecundability in Late Reproductive-Aged African American Women.
晚班工作和晚育龄非洲裔美国女性的生育能力。
  • DOI:
    10.1089/jwh.2019.8166
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Sponholtz,ToddR;Bethea,TraciN;Ruiz-Narváez,EdwardA;Boynton-Jarrett,Renee;Palmer,JulieR;Rosenberg,Lynn;Wise,LaurenA
  • 通讯作者:
    Wise,LaurenA
Effect of Culturally Tailored, Internet-Delivered Cognitive Behavioral Therapy for Insomnia in Black Women: A Randomized Clinical Trial.
文化定制、互联网提供的认知行为疗法对黑人女性失眠的影响:一项随机临床试验。
  • DOI:
    10.1001/jamapsychiatry.2022.0653
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    25.8
  • 作者:
    Zhou,EricS;Ritterband,LeeM;Bethea,TraciN;Robles,YvonneP;Heeren,TimothyC;Rosenberg,Lynn
  • 通讯作者:
    Rosenberg,Lynn
Addition of polygenic risk score to a risk calculator for prediction of breast cancer in US Black women.
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Kimberly A Bertrand其他文献

Planetary Health Diet Index in relation to mortality in a prospective cohort study of United States Black females
一项针对美国黑人女性的前瞻性队列研究:行星健康饮食指数与死亡率的关系
  • DOI:
    10.1016/j.ajcnut.2025.01.023
  • 发表时间:
    2025-03-01
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Yifei Shan;Kimberly A Bertrand;Jessica L Petrick;Shanshan Sheehy;Julie R Palmer
  • 通讯作者:
    Julie R Palmer
Hormone therapy use and young-onset breast cancer: a pooled analysis of prospective cohorts included in the Premenopausal Breast Cancer Collaborative Group
激素治疗的使用与早发性乳腺癌:绝经前乳腺癌协作组纳入的前瞻性队列的荟萃分析
  • DOI:
    10.1016/s1470-2045(25)00211-6
  • 发表时间:
    2025-07-01
  • 期刊:
  • 影响因子:
    35.900
  • 作者:
    Katie M O’Brien;Melissa G House;Mandy Goldberg;Michael E Jones;Clarice R Weinberg;Amy Berrington de Gonzalez;Kimberly A Bertrand;William J Blot;Jessica Clague DeHart;Fergus J Couch;Montserrat Garcia-Closas;Graham G Giles;Victoria A Kirsh;Cari M Kitahara;Woon-Puay Koh;Hannah Lui Park;Roger L Milne;Julie R Palmer;Alpa V Patel;Thomas E Rohan;Dale P Sandler
  • 通讯作者:
    Dale P Sandler

Kimberly A Bertrand的其他文献

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{{ truncateString('Kimberly A Bertrand', 18)}}的其他基金

Advancing breast cancer risk prediction in national cohorts: the role of mammogram-based deep learning
推进国家队列中的乳腺癌风险预测:基于乳房 X 光检查的深度学习的作用
  • 批准号:
    10734544
  • 财政年份:
    2023
  • 资助金额:
    $ 204.28万
  • 项目类别:
Socio-environmental context in monoclonal gammopathy of undetermined significance (MGUS) disparities
意义未明的单克隆丙种球蛋白病 (MGUS) 差异的社会环境背景
  • 批准号:
    10622591
  • 财政年份:
    2021
  • 资助金额:
    $ 204.28万
  • 项目类别:
Socio-environmental context in monoclonal gammopathy of undetermined significance (MGUS) disparities
意义未明的单克隆丙种球蛋白病 (MGUS) 差异的社会环境背景
  • 批准号:
    10410510
  • 财政年份:
    2021
  • 资助金额:
    $ 204.28万
  • 项目类别:
Determinants of the racial/ethnic disparity in MGUS risk: An epidemiologic study in 4 cohorts
MGUS 风险种族/民族差异的决定因素:4 个队列的流行病学研究
  • 批准号:
    10217882
  • 财政年份:
    2021
  • 资助金额:
    $ 204.28万
  • 项目类别:
Socio-environmental context in monoclonal gammopathy of undetermined significance (MGUS) disparities
意义未明的单克隆丙种球蛋白病 (MGUS) 差异的社会环境背景
  • 批准号:
    10217474
  • 财政年份:
    2021
  • 资助金额:
    $ 204.28万
  • 项目类别:
Determinants of the racial/ethnic disparity in MGUS risk: An epidemiologic study in 4 cohorts
MGUS 风险种族/民族差异的决定因素:4 个队列的流行病学研究
  • 批准号:
    10491335
  • 财政年份:
    2021
  • 资助金额:
    $ 204.28万
  • 项目类别:
A Follow-up Study for Causes of Cancer in Black Women
黑人女性癌症病因的后续研究
  • 批准号:
    10523801
  • 财政年份:
    2012
  • 资助金额:
    $ 204.28万
  • 项目类别:

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激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
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