A Follow-up Study for Causes of Cancer in Black Women
A Follow-up Study for Causes of Cancer in Black Women
批准号:
10701009
负责人:
Kimberly A Bertrand
金额:
$204.28万
依托单位国家:
美国
项目类别:
财政年份:
2012
资助国家:
美国
项目状态:
未结题
起止时间:
2012-09-21 至 2027-08-31
关键词:
AddressAffectAgeAlzheimer&aposs DiseaseArchivesBehaviorBehavioralBiological AssayBiological MarkersBiological Specimen BanksBloodBlood specimenBreastCOVID-19Cancer EtiologyCancer SurvivorCancer SurvivorshipCardiovascular DiseasesCessation of lifeCharacteristicsCollectionColon CarcinomaColonic PolypsColorectalColorectal CancerDNADNA RepositoryDataData CollectionData FilesDiagnosisDiseaseDisparityEnd stage renal failureEndometrialEnrollmentEnvironmental ExposureEnvironmental Risk FactorEthnic PopulationFollow-Up StudiesFrequenciesFundingFutureGeneticGoalsHealthHealth StatusHypertensionImpaired cognitionIncidenceIndividualInfertilityInfrastructureKnowledgeLengthLeukocytesLinkLiverLungLupusMaintenanceMalignant NeoplasmsMalignant neoplasm of lungMalignant neoplasm of ovaryMalignant neoplasm of pancreasMammary NeoplasmsMammographyMedicalMedical RecordsMedicareMentorsMethodologyMethodsMinority GroupsModernizationMolecular Epidemiology of CancerMultiple MyelomaNeighborhoodsNewly DiagnosedNewly Diagnosed DiseaseNon-Insulin-Dependent Diabetes MellitusObesityOutcomeOvarianPancreasPaperParticipantPeer ReviewPharmaceutical PreparationsPlasmaPremature BirthPreparationProspective, cohort studyPsychosocial FactorPublicationsQuality of lifeQuestionnairesRNARecurrenceRenal carcinomaReportingResearchResearch DesignResearch PersonnelRiskRisk FactorsRisk ReductionSARS-CoV-2 infectionSalivaSamplingSarcoidosisSerumSleep DisordersSourceSpecimenStructural RacismSystemTimeTissue BanksTissue MicroarrayTissue SampleTrainingTumor TissueUnderrepresented MinorityUpdateUterine FibroidsVulnerable PopulationsWomanWomen&aposs Healthblack womencancer diagnosiscancer health disparitycancer riskcancer survivalcohortcostdata sharingfollow-upgenetic risk factorhealth disparityhealth inequalitiesindexinginterestmalignant breast neoplasmmicrobialminority investigatormortalityneoplasm registrynovelobservational cohort studypatient engagementracial disparityracial health disparityracial populationrepositoryresearch studyresponsesaliva samplesocialtumorvirtualweb site
中文摘要
普遍存在的健康差距影响着美国黑人妇女,现在已被广泛认识到
英文摘要
Pervasive health disparities affecting U.S. Black women are now widely recognized, but large gaps in
knowledge remain. We began the Black Women’s Health Study (BWHS) in 1995 to identify reasons for
disparities, including cancer health disparities; at that time Black women represented a very small proportion of
participants in observational cohort studies. We enrolled 59,000 participants over an 8-month period in 1995
via a lengthy mail questionnaire. Subsequently, participants were asked to complete follow-up questionnaires,
usually four pages in length, every two years, either on paper or online. In the most recent questionnaire cycle,
responses were split equally between the two methods. Over 51,000 participants are still alive and response
rates continue to be good. Among approximately 48,000 who were sent a 2019/20 questionnaire, 71%
completed it and 79% responded to either that questionnaire or the prior one. Saliva samples as a source of
germline and microbial DNA have been obtained and stored for 27,800 participants and blood samples for
13,030 participants. Breast tumor samples have been obtained for over 1,000 breast cancer cases; tumor
tissue collection was begun in the most recent funding period for four other cancers. BWHS research covers
the spectrum from individual behaviors, medication use, and other characteristics, to psychosocial factors,
genetic factors, and neighborhood-level factors. Peer-reviewed publications have addressed a range of health
conditions: cancers that include breast, lung, ovarian, colorectal, endometrial, pancreatic, liver, and multiple
myeloma; type 2 diabetes; obesity; lupus; sarcoidosis; preterm birth; infertility; uterine leiomyoma; cognitive
decline; sleep disorders; hypertension; COVID-19 infection; and mortality. More than half of current participants
are under age 64, affording the potential for additional research on cancer etiology, including with collection of
new or repeated exposures and covariates. During the next funding period, we expect to produce impactful
findings with regard to risk of multiple myeloma and colorectal, lung, and pancreatic cancer; breast and
colorectal cancer survivorship; cognitive decline and Alzheimer’s disease; end-stage renal disease; and other
conditions, such as COVID-19, that disproportionately affect Black women. (According to the National Death
Index (NDI), over 100 BWHS participants died from COVID-19 infection in 2020.) To reduce costs, we will
reduce the frequency of questionnaires while still linking to NDI, Medicare, and cancer registries to identify and
confirm new cancers, other illnesses, and deaths. We will continue to share BWHS data and samples with
outside investigators, and underrepresented minority investigators in particular, and will modernize our website
and data sharing systems to increase accessibility. Continued follow-up of this landmark study is critical to
inform opportunities for risk reduction in a vulnerable population and to close the gap in racial disparities in
cancer and other illnesses.
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Night Shift Work and Fecundability in Late Reproductive-Aged African American Women.
晚班工作和晚育龄非洲裔美国女性的生育能力。
DOI:
10.1089/jwh.2019.8166
发表时间:
2021
期刊:
Journal of women's health (2002)
影响因子:
--
作者:
[Sponholtz,ToddR, Bethea,TraciN, Ruiz-Narváez,EdwardA, Boynton-Jarrett,Renee, Palmer,JulieR, Rosenberg,Lynn, Wise,LaurenA]
通讯作者:
Wise,LaurenA
DOI:
10.1186/s13058-022-01577-1
发表时间:
2022-12-05
期刊:
Breast cancer research : BCR
影响因子:
--
作者:
[]
通讯作者:
Effect of Culturally Tailored, Internet-Delivered Cognitive Behavioral Therapy for Insomnia in Black Women: A Randomized Clinical Trial.
文化定制、互联网提供的认知行为疗法对黑人女性失眠的影响:一项随机临床试验。
DOI:
10.1001/jamapsychiatry.2022.0653
发表时间:
2022
期刊:
JAMA psychiatry
影响因子:
25.8
作者:
[Zhou,EricS, Ritterband,LeeM, Bethea,TraciN, Robles,YvonneP, Heeren,TimothyC, Rosenberg,Lynn]
通讯作者:
Rosenberg,Lynn
DOI:
10.1186/s13058-023-01748-8
发表时间:
2024-01-02
期刊:
Breast cancer research : BCR
影响因子:
--
作者:
[]
通讯作者:
DOI:
10.1186/s12864-022-08837-6
发表时间:
2022-08-25
期刊:
BMC genomics
影响因子:
4.4
作者:
[]
通讯作者:
共 12 条
Advancing breast cancer risk prediction in national cohorts: the role of mammogram-based deep learning
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批准号:10734544
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项目类别:
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资助金额:$69.83万
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财政年份:2023
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负责人:Kimberly A Bertrand
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依托单位:
Socio-environmental context in monoclonal gammopathy of undetermined significance (MGUS) disparities
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批准号:10622591
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资助金额:$68.5万
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财政年份:2021
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负责人:Kimberly A Bertrand
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依托单位:
Socio-environmental context in monoclonal gammopathy of undetermined significance (MGUS) disparities
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批准号:10410510
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项目类别:
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资助金额:$69.46万
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财政年份:2021
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负责人:Kimberly A Bertrand
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依托单位:
Determinants of the racial/ethnic disparity in MGUS risk: An epidemiologic study in 4 cohorts
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批准号:10217882
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项目类别:
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资助金额:$97.57万
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财政年份:2021
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负责人:Kimberly A Bertrand
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依托单位:
Socio-environmental context in monoclonal gammopathy of undetermined significance (MGUS) disparities
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批准号:10217474
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项目类别:
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资助金额:$76.01万
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财政年份:2021
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负责人:Kimberly A Bertrand
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依托单位:
Determinants of the racial/ethnic disparity in MGUS risk: An epidemiologic study in 4 cohorts
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批准号:10491335
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项目类别:
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资助金额:$85.0万
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财政年份:2021
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负责人:Kimberly A Bertrand
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依托单位:
A Follow-up Study for Causes of Cancer in Black Women
-
批准号:10523801
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项目类别:
-
资助金额:$213.47万
-
财政年份:2012
-
负责人:Kimberly A Bertrand
-
依托单位:
海外基金