A Follow-up Study for Causes of Cancer in Black Women

黑人女性癌症病因的后续研究

• 批准号: 10523801
• 负责人: Kimberly A Bertrand
• 金额: $ 213.47万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-21 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10523801
• 关键词: Address; Affect; Age; Alzheimer' s Disease; Archives; Behavior; Behavioral; Biological Assay; Biological Markers; Biological Specimen Banks; Blood; Blood specimen; Breast; COVID-19; Cancer Etiology; Cancer Survivor; Cancer Survivorship; Cardiovascular Diseases; Cessation of life; Characteristics; Cohort Studies; Collection; Colon Carcinoma; Colonic Polyps; Colorectal; Colorectal Cancer; DNA; DNA Repository; Data; Data Analytics; Data Collection; Data Files; Diagnosis; Disease; End stage renal failure; Endometrial; Enrollment; Environmental Exposure; Environmental Risk Factor; Ethnic group; Follow-Up Studies; Frequencies; Funding; Future; Genetic; Goals; Health; Health Status; Hypertension; Impaired cognition; Incidence; Individual; Infertility; Infrastructure; Knowledge; Length; Leukocytes; Link; Liver; Lung; Lupus; Maintenance; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of ovary; Malignant neoplasm of pancreas; Mammary Neoplasms; Mammography; Medical; Medical Records; Medicare; Mentors; Methodology; Methods; Minority Groups; Modernization; Molecular Epidemiology of Cancer; Multiple Myeloma; Neighborhoods; Newly Diagnosed; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Ovarian; Pancreas; Paper; Participant; Peer Review; Pharmaceutical Preparations; Plasma; Premature Birth; Preparation; Prospective cohort study; Psychosocial Factor; Publications; Quality of life; Questionnaires; RNA; Recurrence; Renal carcinoma; Reporting; Research; Research Design; Research Personnel; Risk; Risk Factors; Risk Reduction; SARS-CoV-2 infection; Saliva; Sampling; Sarcoidosis; Serum; Sleep Disorders; Source; Specimen; Structural Racism; System; Time; Tissue Banks; Tissue Microarray; Tissue Sample; Training; Treatment outcome; Tumor Tissue; Underrepresented Minority; Update; Uterine Fibroids; Vulnerable Populations; Woman; Women' s Health; black women; cancer diagnosis; cancer health disparity; cancer risk; cancer survival; cohort; cost; data sharing; disease diagnosis; follow-up; genetic risk factor; health disparity; health inequalities; indexing; interest; malignant breast neoplasm; microbial; minority investigator; mortality; neoplasm registry; novel; patient engagement; racial and ethnic; racial disparity; racial health disparity; repository; research study; response; saliva sample; social; tumor; virtual; web site

Pervasive health disparities affecting U.S. Black women are now widely recognized, but large gaps in knowledge remain. We began the Black Women’s Health Study (BWHS) in 1995 to identify reasons for disparities, including cancer health disparities; at that time Black women represented a very small proportion of participants in observational cohort studies. We enrolled 59,000 participants over an 8-month period in 1995 via a lengthy mail questionnaire. Subsequently, participants were asked to complete follow-up questionnaires, usually four pages in length, every two years, either on paper or online. In the most recent questionnaire cycle, responses were split equally between the two methods. Over 51,000 participants are still alive and response rates continue to be good. Among approximately 48,000 who were sent a 2019/20 questionnaire, 71% completed it and 79% responded to either that questionnaire or the prior one. Saliva samples as a source of germline and microbial DNA have been obtained and stored for 27,800 participants and blood samples for 13,030 participants. Breast tumor samples have been obtained for over 1,000 breast cancer cases; tumor tissue collection was begun in the most recent funding period for four other cancers. BWHS research covers the spectrum from individual behaviors, medication use, and other characteristics, to psychosocial factors, genetic factors, and neighborhood-level factors. Peer-reviewed publications have addressed a range of health conditions: cancers that include breast, lung, ovarian, colorectal, endometrial, pancreatic, liver, and multiple myeloma; type 2 diabetes; obesity; lupus; sarcoidosis; preterm birth; infertility; uterine leiomyoma; cognitive decline; sleep disorders; hypertension; COVID-19 infection; and mortality. More than half of current participants are under age 64, affording the potential for additional research on cancer etiology, including with collection of new or repeated exposures and covariates. During the next funding period, we expect to produce impactful findings with regard to risk of multiple myeloma and colorectal, lung, and pancreatic cancer; breast and colorectal cancer survivorship; cognitive decline and Alzheimer’s disease; end-stage renal disease; and other conditions, such as COVID-19, that disproportionately affect Black women. (According to the National Death Index (NDI), over 100 BWHS participants died from COVID-19 infection in 2020.) To reduce costs, we will reduce the frequency of questionnaires while still linking to NDI, Medicare, and cancer registries to identify and confirm new cancers, other illnesses, and deaths. We will continue to share BWHS data and samples with outside investigators, and underrepresented minority investigators in particular, and will modernize our website and data sharing systems to increase accessibility. Continued follow-up of this landmark study is critical to inform opportunities for risk reduction in a vulnerable population and to close the gap in racial disparities in cancer and other illnesses.

影响美国黑人女性的普遍健康差异现已得到广泛认可，但在健康方面存在巨大差距 知识依然存在。我们于 1995 年开始开展黑人女性健康研究 (BWHS)，旨在找出黑人女性健康问题的原因 差异，包括癌症健康差异；当时黑人女性所占比例很小 观察性队列研究的参与者。 1995 年的 8 个月内，我们招募了 59,000 名参与者 通过冗长的邮件调查问卷。随后，参与者被要求填写后续调查问卷， 通常为四页，每两年一次，纸质或在线形式。在最近的问卷调查周期中， 两种方法的反应均等。超过 51,000 名参与者仍然活着并做出回应 利率继续良好。在大约 48,000 名收到 2019/20 年调查问卷的人中，71% 完成了该调查，79% 的人回答了该调查问卷或之前的调查问卷。唾液样本作为来源 已获取并储存了 27,800 名参与者的种系和微生物 DNA 以及血液样本 13,030 名参与者。已获得超过1000例乳腺癌病例的乳腺肿瘤样本；瘤 在最近的资助期内开始了其他四种癌症的组织收集工作。 BWHS 研究涵盖 从个人行为、药物使用和其他特征到社会心理因素的范围， 遗传因素和邻里因素。同行评审的出版物涉及一系列健康问题 病症：癌症，包括乳腺癌、肺癌、卵巢癌、结直肠癌、子宫内膜癌、胰腺癌、肝癌和多种癌症 骨髓瘤； 2型糖尿病；肥胖;狼疮;结节病;早产；不孕症；子宫肌瘤;认知的 衰退;睡眠障碍；高血压; 2019冠状病毒病感染;和死亡率。目前超过一半的参与者 年龄在 64 岁以下，提供了对癌症病因学进行更多研究的潜力，包括收集 新的或重复的暴露和协变量。在下一个资助期间，我们预计会产生有影响力的成果 关于多发性骨髓瘤、结直肠癌、肺癌和胰腺癌风险的研究结果；乳房和 结直肠癌存活率；认知能力下降和阿尔茨海默病；终末期肾病；和其他 COVID-19 等疾病对黑人女性的影响尤为严重。 （根据国家死亡 指数 (NDI)，2020 年有超过 100 名 BWHS 参与者死于 COVID-19 感染。）为了降低成本，我们将 减少调查问卷的频率，同时仍与 NDI、医疗保险和癌症登记处联系起来，以识别和 确认新的癌症、其他疾病和死亡。我们将继续与以下机构分享 BWHS 数据和样本： 外部调查员，特别是代表性不足的少数族裔调查员，并将使我们的网站现代化 和数据共享系统，以提高可访问性。继续跟进这项具有里程碑意义的研究对于 为弱势群体提供减少风险的机会，并缩小种族差异 癌症和其他疾病。