A 2D Stationary X-ray Source System for Improved Breast Tomosynthesis Imaging

项目摘要/摘要 该赠款申请计划使用独特的固定式多X射线源阵列(MXA)技术 在我们目前的R01下开发并应用于数字乳房断层合成(DBT)以：1)显著提高 通过扩展MXA技术来产生临床实用的二维(2D)MXA的DBT图像质量 和2)展示了一个有能力的和完全特性化的2D mxa DBT系统，用于在 R01学术-产业伙伴关系计划的后续计划。 20世纪70年代，当第一个基于胶片的商业断层合成系统被开发出来时，它是 意识到X射线源的2D运动相对于1D运动显著改善了图像质量，这是由于 更好地模糊感兴趣平面上方和下方的结构的阴影。所有现有商业广告 DBT系统使用一维运动，因为二维机械运动复杂且昂贵，而且会显著 增加扫描时间，这已经是太长的扫描在4至25 S与一维运动为基础的系统。请将此与 乳房X光检查，最好将扫描次数控制在2 S以下，以最大限度地减少患者运动伪影。 通过满足扫描时间限制，扩展MXA技术使2D乳房断层合成成为现实- 将提供比市场上所有商业乳房断层合成系统更优越的性能 今天，同时降低了系统规模和成本。最终结果将是一个显著的增长 DBT系统的能力和其可获得性的扩大，为更多的人带来更好的护理 更快。 本申请的具体目标是： 目的1.采用建模和实验相结合的方法设计二维MXA-DBT原型系统 目标2.建立2DMxa DBT原型系统 目的3.评估2DMxa DBT原型系统的性能

PROJECT SUMMARY/ABSTRACT This grant application proposes to use the unique stationary Multi-X-ray-source Array (MXA) technology developed and applied to digital breast tomosynthesis (DBT) under our current R01 to: 1) significantly improve DBT image quality by extending the MXA technology to produce a clinically practical two-dimensional (2D) MXA and 2) demonstrate a capable and fully characterized 2D MXA DBT system to use for clinical trials under a follow-on R01 Academic–Industrial Partnership program. By the time the first film-based commercial tomosynthesis systems were developed in the 1970s, it was realized that 2D motion of the X-ray source significantly improved image quality relative to 1D motion due to better blurring of the shadows of structures both above and below the plane of interest. All existing commercial DBT systems use 1D motion because 2D mechanical motion is complicated and expensive and would significantly increase scan times which are already too long at 4 to 25 s with the 1D motion-based systems. Compare this to mammography, where it is preferred to keep scan times under 2 s to minimize patient-motion artifacts. Extending MXA technology to make 2D breast tomosynthesis practical – by meeting scan time constraints – will provide superior performance compared with all commercial breast tomosynthesis systems on the market today, while at the same time decreasing system size and cost. The net result would be a significant increase in the capability of DBT systems and a broadening of their availability to bring better care to more people sooner. The Specific Aims of this application are: Aim 1. Use modeling and experiments to design the 2D MXA-DBT prototype system Aim 2. Build 2D MXA DBT prototype system Aim 3. Evaluate performance of 2D MXA DBT prototype system