A 2D Stationary X-ray Source System for Improved Breast Tomosynthesis Imaging

用于改进乳腺断层合成成像的 2D 固定 X 射线源系统

• 批准号: 10364342
• 负责人: PAUL R SCHWOEBEL
• 金额: $ 8.87万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-15 至 2022-08-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10364342
• 关键词: Anodes; Applications Grants; Breast; Calibration; California; Caring; Cathodes; Characteristics; Clinical; Clinical Trials; Collimator; Digital Breast Tomosynthesis; Dimensions; Electronics; Elements; Filament; Film; Frequencies; Image; Imaging technology; Individual; International; Mammography; Mechanics; Modeling; Morphologic artifacts; Motion; New Mexico; Output; Patients; Performance; Persons; Protocols documentation; Research; Roentgen Rays; Scanning; Source; Spottings; Structure; System; Technology; Time; Translations; Tungsten; Universities; X-Ray Medical Imaging; base; cost; deep learning; design; detector; experimental study; improved; industry partner; interest; meetings; professor; programs; prototype; reconstruction; simulation; success; tomography; tomosynthesis; two-dimensional

PROJECT SUMMARY/ABSTRACT This grant application proposes to use the unique stationary Multi-X-ray-source Array (MXA) technology developed and applied to digital breast tomosynthesis (DBT) under our current R01 to: 1) significantly improve DBT image quality by extending the MXA technology to produce a clinically practical two-dimensional (2D) MXA and 2) demonstrate a capable and fully characterized 2D MXA DBT system to use for clinical trials under a follow-on R01 Academic–Industrial Partnership program. By the time the first film-based commercial tomosynthesis systems were developed in the 1970s, it was realized that 2D motion of the X-ray source significantly improved image quality relative to 1D motion due to better blurring of the shadows of structures both above and below the plane of interest. All existing commercial DBT systems use 1D motion because 2D mechanical motion is complicated and expensive and would significantly increase scan times which are already too long at 4 to 25 s with the 1D motion-based systems. Compare this to mammography, where it is preferred to keep scan times under 2 s to minimize patient-motion artifacts. Extending MXA technology to make 2D breast tomosynthesis practical – by meeting scan time constraints – will provide superior performance compared with all commercial breast tomosynthesis systems on the market today, while at the same time decreasing system size and cost. The net result would be a significant increase in the capability of DBT systems and a broadening of their availability to bring better care to more people sooner. The Specific Aims of this application are: Aim 1. Use modeling and experiments to design the 2D MXA-DBT prototype system Aim 2. Build 2D MXA DBT prototype system Aim 3. Evaluate performance of 2D MXA DBT prototype system

项目概要/摘要 该拨款申请建议使用独特的固定多 X 射线源阵列 (MXA) 技术 在我们当前的 R01 下开发并应用于数字乳腺断层合成 (DBT) 可以： 1) 显着改善 通过扩展 MXA 技术生产临床实用的二维 (2D) MXA 来提高 DBT 图像质量 2) 展示一个功能强大且特征齐全的 2D MXA DBT 系统，可用于以下条件下的临床试验： 后续 R01 学术-工业合作伙伴计划。 当第一个基于胶片的商业断层合成系统在 20 世纪 70 年代开发出来时，它已经 意识到 X 射线源的 2D 运动相对于 1D 运动显着提高了图像质量，因为 更好地模糊感兴趣平面上方和下方结构的阴影。所有现有商业 DBT 系统使用一维运动，因为二维机械运动复杂且昂贵，并且会显着影响 增加扫描时间，对于基于 1D 运动的系统，扫描时间已经太长，为 4 至 25 秒。将此与 乳房 X 光检查，最好将扫描时间保持在 2 秒以下，以尽量减少患者运动伪影。 扩展 MXA 技术，使 2D 乳房断层合成实用 - 通过满足扫描时间限制 - 与市场上所有商用乳腺断层合成系统相比，将提供卓越的性能 今天，同时减小系统尺寸和成本。最终结果将是显着增加 DBT 系统的能力及其可用性的扩大，为更多人提供更好的护理 早点。 该应用程序的具体目标是： 目标 1. 使用建模和实验设计 2D MXA-DBT 原型系统 目标 2. 构建 2D MXA DBT 原型系统 目标 3. 评估 2D MXA DBT 原型系统的性能