Alliance NCORP Research Base

联盟NCORP研究基地 项目总结/摘要 肿瘤临床试验联盟（Alliance for Clinical Trials in Oncology）是五个国家临床试验网络组织之一， 作为联盟NCI社区肿瘤学研究计划（NCORP）的上级组织 研究基地（Alliance NCORP）。联盟NCORP进行干预性和观察性临床 和翻译研究以及数据库研究-所有这些都解决了与以下相关的重要问题： 癌症预防、症状控制和癌症护理提供。此外，联盟NCORP还开展了 临床上重要的生活质量研究，嵌入在癌症治疗试验中。它的地方很特别 强调少数群体、服务不足和老年患者有患癌症的风险或被诊断患有癌症， 与NCORP社区站点和少数民族/服务不足社区站点建立牢固的协作关系。的 联盟NCORP委员会成员包括来自社区和 学术医疗中心，以及患者的倡导者，从而产生与癌症相关的研究成果 美国各地的患者。联盟NCORP还强调指导和培训初级 investigators.在过去的资助周期中，即，自2014年8月以来，联盟NCORP已经发布了148份 手稿和摘要。这项工作包括在以下领域改变实践的研究： 预防化疗引起的恶心和呕吐，预防 骨转移、脑转移的管理和患者报告结局的整合 癌症临床试验联盟NCORP进行翻译研究，需要收集 肿瘤组织、癌前组织样本、血液和其他人类生物标本;并共享数据和 生物样本用于合并分析和其他科学合作。这些生物标本创造了一个 从机械学的角度理解临床观察的宝贵知识库。联盟 NCORP还与其他NCI资助的调查人员和财团以及 通过非NCI来源支持的调查人员。这种改变实践的研究和科学 联盟NCORP回答的问题为临床和 转化肿瘤学，只能在公共资助的研究网络内进行。

Alliance NCORP Research Base Project Summary/Abstract The Alliance for Clinical Trials in Oncology (Alliance), one of five National Clinical Trials Network groups, serves as the parent organization for the Alliance NCI Community Oncology Research Program (NCORP) Research Base (Alliance NCORP). The Alliance NCORP conducts interventional and observational clinical and translational research as well as database studies – all of which address important questions relevant to cancer prevention, symptom control, and cancer care delivery. In addition, the Alliance NCORP conducts clinically important quality of life studies that are embedded within cancer treatment trials. It places special emphasis on minority, underserved and older patients at risk for or diagnosed with cancer, and on building strong collegial relationships with NCORP Community sites and Minority/Underserved Community sites. The Alliance NCORP committee membership includes rich representation from both community-based and academic medical centers, as well as patient advocates, thus generating research results relevant to cancer patients across the United States. The Alliance NCORP also emphasizes mentorship and training of junior investigators. Over this past grant cycle, i.e., since August 2014, the Alliance NCORP has published 148 manuscripts and abstracts. This work has included practice-changing research in such areas as the prevention of chemotherapy-induced nausea and vomiting, the prevention of skeletal-related events from osseous metastases, the management of brain metastases, and the integration of patient-reported outcomes into cancer clinical trials. The Alliance NCORP conducts translational research that requires the collection of tumor tissue, premalignant tissue samples, blood, and other human biospecimens; and shares data and biospecimens for pooled analyses and other scientific collaborations. These biospecimens create an invaluable repository for understanding clinical observations from a mechanistic standpoint. The Alliance NCORP also collaborates broadly with other NCI-funded investigators and consortia, as well as with investigators supported through non-NCI sources. This practice-changing research and the scientific questions answered by the Alliance NCORP provide meaningful and innovative contributions to clinical and translational oncology, which can be conducted only within a publicly-funded research network.