Alliance NCORP Research Base

联盟NCORP研究基地

• 批准号: 10908061
• 负责人: Suzanne George
• 金额: $ 59.74万
• 依托单位: ALLIANCE NCTN FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10908061
• 关键词: Academic Medical Centers; Address; Advocate; Aging; Area; Attention; Behavior; Blood; Cancer Burden; Cancer Patient; Cancer Research Project; Caregivers; Clinical; Clinical Oncology; Clinical Research; Clinical Trials; Collaborations; Collection; Committee Membership; Communities; Community Clinical Oncology Program; Companions; Data; Data Reporting; Databases; Development; Diagnosis; Disease; Disparity; Early Diagnosis; Education; Elderly; Functional disorder; Funding; Funding Opportunities; Grant; Health; Human; Incidence; Intervention; Maintenance; Malignant Neoplasms; Manuscripts; Mentors; Mentorship; Metastatic Neoplasm to the Bone; Metastatic malignant neoplasm to brain; Minority; Minority Groups; Mission; Monitor; Morbidity - disease rate; National Cancer Institute; National Clinical Trials Network; Natural History; Nausea and Vomiting; Oncologist; Oncology; Outcome; Outcome Assessment; Outcomes Research; Parents; Patient Outcomes Assessments; Patients; Pharmacologic Substance; Population; Prevalence; Prevention; Publishing; Quality of life; Research; Research Methodology; Research Personnel; Research Priority; Risk; Site; Source; Symptoms; Technology; Tissue Sample; Toxic effect; Training; Translational Research; Tumor Tissue; Underserved Population; United States; Work; base; cancer care; cancer clinical trial; cancer health disparity; cancer prevention; cancer risk; cancer therapy; care delivery; chemotherapy; clinically relevant; clinically significant; community engagement; curative treatments; data sharing; disparity elimination; disparity reduction; experience; financial toxicity; forging; health disparity; high risk; improved; innovation; mortality; multidisciplinary; next generation; novel; older patient; premalignant; prevent; programs; reduce symptoms; repository; skeletal-related events; survivorship; translational oncology; treatment trial; underserved community

Alliance NCORP Research Base Project Summary/Abstract The Alliance for Clinical Trials in Oncology (Alliance), one of five National Clinical Trials Network groups, serves as the parent organization for the Alliance NCI Community Oncology Research Program (NCORP) Research Base (Alliance NCORP). The Alliance NCORP conducts interventional and observational clinical and translational research as well as database studies – all of which address important questions relevant to cancer prevention, symptom control, and cancer care delivery. In addition, the Alliance NCORP conducts clinically important quality of life studies that are embedded within cancer treatment trials. It places special emphasis on minority, underserved and older patients at risk for or diagnosed with cancer, and on building strong collegial relationships with NCORP Community sites and Minority/Underserved Community sites. The Alliance NCORP committee membership includes rich representation from both community-based and academic medical centers, as well as patient advocates, thus generating research results relevant to cancer patients across the United States. The Alliance NCORP also emphasizes mentorship and training of junior investigators. Over this past grant cycle, i.e., since August 2014, the Alliance NCORP has published 148 manuscripts and abstracts. This work has included practice-changing research in such areas as the prevention of chemotherapy-induced nausea and vomiting, the prevention of skeletal-related events from osseous metastases, the management of brain metastases, and the integration of patient-reported outcomes into cancer clinical trials. The Alliance NCORP conducts translational research that requires the collection of tumor tissue, premalignant tissue samples, blood, and other human biospecimens; and shares data and biospecimens for pooled analyses and other scientific collaborations. These biospecimens create an invaluable repository for understanding clinical observations from a mechanistic standpoint. The Alliance NCORP also collaborates broadly with other NCI-funded investigators and consortia, as well as with investigators supported through non-NCI sources. This practice-changing research and the scientific questions answered by the Alliance NCORP provide meaningful and innovative contributions to clinical and translational oncology, which can be conducted only within a publicly-funded research network.

联盟NCORP研究基地 项目概要/摘要 肿瘤学临床试验联盟（联盟）是五个国家临床试验网络团体之一， 作为联盟 NCI 社区肿瘤​​学研究计划 (NCORP) 的上级组织 研究基地（联盟NCORP）。联盟NCORP开展介入性和观察性临床 和转化研究以及数据库研究——所有这些都解决了与 癌症预防、症状控制和癌症护理服务。此外，联盟 NCORP 还开展 癌症治疗试验中包含临床重要的生活质量研究。它有特殊的地方 重点关注有癌症风险或诊断出患有癌症的少数族裔、服务不足的患者和老年患者，并建立 与 NCORP 社区站点和少数族裔/服务不足的社区站点建立牢固的合作关系。这 联盟 NCORP 委员会成员包括来自社区和社区的丰富代表 学术医疗中心以及患者权益倡导者，从而产生与癌症相关的研究成果 美国各地的患者。联盟 NCORP 还强调对初级人员的指导和培训 调查人员。在过去的资助周期中，即自 2014 年 8 月以来，联盟 NCORP 已发布了 148 手稿和摘要。这项工作包括在以下领域改变实践的研究 预防化疗引起的恶心和呕吐，预防骨骼相关事件 骨转移、脑转移的治疗以及患者报告结果的整合 进入癌症临床试验。联盟 NCORP 开展转化研究，需要收集 肿瘤组织、癌前组织样本、血液和其他人体生物样本；并共享数据和 用于汇总分析和其他科学合作的生物样本。这些生物样本创造了 从机械角度理解临床观察的宝贵资料库。联盟 NCORP 还与其他 NCI 资助的研究人员和财团以及 研究人员通过非 NCI 来源提供支持。这项改变实践的研究和科学 联盟 NCORP 回答的问题为临床和临床研究提供了有意义和创新的贡献 转化肿瘤学，只能在公共资助的研究网络内进行。

项目成果

Patient Experience, Adverse Event Reporting, and Clinical Trial Design.

患者体验、不良事件报告和临床试验设计。

• DOI: 10.1200/jco.23.01976
• 发表时间: 2024
• 期刊: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
• 作者: Neuman,HeatherB

Can a gastric cancer risk survey identify high-risk patients for endoscopic screening? A pilot study.

• DOI: 10.1016/j.jss.2018.02.053
• 发表时间: 2018-07
• 期刊: The Journal of surgical research
• 作者: In H;Langdon-Embry M;Gordon L;Schechter CB;Wylie-Rosett J;Castle PE;Margaret Kemeny M;Rapkin BD
• 通讯作者: Rapkin BD

An eHealth symptom and complication management program for cancer patients with newly created ostomies and their caregivers (Alliance): a pilot feasibility randomized trial.

• DOI: 10.1186/s12885-023-10919-x
• 发表时间: 2023-06-10
• 期刊: BMC CANCER
• 影响因子: 3.8
• 作者: Xu, Shenmeng;Tan, Xianming;Ma, Chunxuan;McElyea, Rebecca S. S.;Shieh, Karl;Stover, Angela M. M.;Smith, Angela;Stitzenberg, Karyn;Basch, Ethan;Song, Lixin
• 通讯作者: Song, Lixin

Validity and Reliability of the US National Cancer Institute's Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE).

• DOI: 10.1001/jamaoncol.2015.2639
• 发表时间: 2015-11
• 期刊: JAMA oncology
• 影响因子: 28.4
• 作者: Dueck AC;Mendoza TR;Mitchell SA;Reeve BB;Castro KM;Rogak LJ;Atkinson TM;Bennett AV;Denicoff AM;O'Mara AM;Li Y;Clauser SB;Bryant DM;Bearden JD 3rd;Gillis TA;Harness JK;Siegel RD;Paul DB;Cleeland CS;Schrag D;Sloan JA;Abernethy AP;Bruner DW;Minasian LM;Basch E;National Cancer Institute PRO-CTCAE Study Group
• 通讯作者: National Cancer Institute PRO-CTCAE Study Group

Chemotherapy-induced nausea and vomiting: incidence and characteristics of persistent symptoms and future directions NCCTG N08C3 (Alliance).

• DOI: 10.1007/s00520-016-3080-y
• 发表时间: 2016-06
• 期刊: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
• 作者: Kottschade L;Novotny P;Lyss A;Mazurczak M;Loprinzi C;Barton D
• 通讯作者: Barton D