Alliance NCORP Research Base

联盟NCORP研究基地 项目摘要/摘要 肿瘤学临床试验联盟(联盟)，五个国家临床试验网络组织之一， 作为联盟NCI社区肿瘤学研究计划(NCORP)的上级组织 研究基地(NCORP联盟)。NCORP联盟进行临床干预和观察性研究 和翻译研究以及数据库研究-所有这些研究都解决了与以下方面相关的重要问题 癌症预防、症状控制和癌症护理服务。此外，NCORP联盟还进行 嵌入癌症治疗试验的具有临床重要性的生活质量研究。它把特别的地方 强调少数群体、服务不足和老年患者有患癌症的风险或被诊断为癌症，并建立 与NCORP社区站点和少数族裔/未得到充分服务的社区站点建立牢固的合作关系。这个 联盟NCORP委员会成员包括来自社区和 学术医学中心以及患者权益倡导者，从而产生与癌症相关的研究结果 美国各地的患者。NCORP联盟还强调对青少年的指导和培训 调查人员。在过去的赠款周期中，也就是自2014年8月以来，NCORP联盟发布了148份 手稿和摘要。这项工作包括在以下领域的实践改变研究 预防化疗引起的恶心和呕吐，预防与骨骼有关的事件 骨转移、脑转移的处理和患者报告结果的整合 进入癌症临床试验。联盟NCORP进行翻译研究，需要收集 肿瘤组织、癌前组织样本、血液和其他人类生物标本；并共享数据和 用于集中分析和其他科学合作的生物检疫剂。这些生物标本创造了一种 从机械论的角度理解临床观察的无价之宝。《联盟》 NCORP还与NCI资助的其他调查人员和财团以及 调查人员通过非NCI来源提供支持。这种改变实践的研究和科学 联盟NCORP回答的问题为临床和治疗提供了有意义的创新贡献 翻译肿瘤学，只能在公共资助的研究网络中进行。

Alliance NCORP Research Base Project Summary/Abstract The Alliance for Clinical Trials in Oncology (Alliance), one of five National Clinical Trials Network groups, serves as the parent organization for the Alliance NCI Community Oncology Research Program (NCORP) Research Base (Alliance NCORP). The Alliance NCORP conducts interventional and observational clinical and translational research as well as database studies – all of which address important questions relevant to cancer prevention, symptom control, and cancer care delivery. In addition, the Alliance NCORP conducts clinically important quality of life studies that are embedded within cancer treatment trials. It places special emphasis on minority, underserved and older patients at risk for or diagnosed with cancer, and on building strong collegial relationships with NCORP Community sites and Minority/Underserved Community sites. The Alliance NCORP committee membership includes rich representation from both community-based and academic medical centers, as well as patient advocates, thus generating research results relevant to cancer patients across the United States. The Alliance NCORP also emphasizes mentorship and training of junior investigators. Over this past grant cycle, i.e., since August 2014, the Alliance NCORP has published 148 manuscripts and abstracts. This work has included practice-changing research in such areas as the prevention of chemotherapy-induced nausea and vomiting, the prevention of skeletal-related events from osseous metastases, the management of brain metastases, and the integration of patient-reported outcomes into cancer clinical trials. The Alliance NCORP conducts translational research that requires the collection of tumor tissue, premalignant tissue samples, blood, and other human biospecimens; and shares data and biospecimens for pooled analyses and other scientific collaborations. These biospecimens create an invaluable repository for understanding clinical observations from a mechanistic standpoint. The Alliance NCORP also collaborates broadly with other NCI-funded investigators and consortia, as well as with investigators supported through non-NCI sources. This practice-changing research and the scientific questions answered by the Alliance NCORP provide meaningful and innovative contributions to clinical and translational oncology, which can be conducted only within a publicly-funded research network.