Discovery and development of voltage-gated sodium channel inhibitors

电压门控钠通道在疼痛传播中的作用是无可争议的，越来越多的遗传证据表明钠通道亚型NaV1.7-NaV1.9特别参与其中。已知动物毒素以高效靶向电压门控离子通道，并且通常具有精细的亚型选择性。我们的研究重点是从蜘蛛和锥体蜗牛的毒液中鉴定和开发新型的钠通道NaV1.7选择性肽，以开发新型的NaV1.7抑制剂来治疗癌症相关的神经性疼痛。

The role of voltage-gated sodium channels in pain propagation is indisputable with mounting genetic evidence of sodium channel subtypes NaV1.7-NaV1.9 specifically being involved. Animal toxins are known to target voltage-gated ion channels at high potency and often with exquisite subtype selectivity. Our research focuses on identifying and developing novel sodium channel NaV1.7 selective peptides from the venom of spiders and cone snails to develop novel NaV1.7 inhibitors for the treatment of cancer-associated neuropathic pain.