Synthesis and Development of Trefoil Factor Peptides

三叶因子肽的合成与开发

• 批准号: 10262601
• 负责人: Ingrid Schroeder
• 金额: $ 5.87万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10262601
• 关键词: Biological; Biology; Development; Evaluation; Family; Gastrointestinal Diseases; Gastrointestinal tract structure; Goals; Inflammatory Bowel Diseases; Irritable Bowel Syndrome; Molecular; Molecular Mechanisms of Action; Mucous Membrane; Peptides; Play; Production; Research; Role; Signal Pathway; Structure; TFF1 gene; Therapeutic; Trefoil; Work; chemical synthesis; disulfide bond; malignant breast neoplasm; member; prevent; receptor; repaired; response; trefoil factor

Trefoil factor family peptides (TFF1, TFF2, and TFF3) are key players in protecting, maintaining, and repairing the gastrointestinal tract and in signaling pathways in breast cancer.. Accordingly, they have the therapeutic potential to treat or prevent a variety of gastrointestinal disorders associated with mucosal damage. TFF peptides share a conserved motif, including three disulfide bonds that stabilize a well-defined three-loop-structure reminiscent of a trefoil. Although multiple functions have been described for TFF peptides, their mechanisms at the molecular level remain poorly understood. Our work is focused on the chemical synthesis of members of the TFF to overcome the recognised bottleneck of synthetic production of this peptide family. This allows us to evaluate putative TFF receptors and protein partners and their importance in the therapeutic potential of these peptides in gastrointestinal disorders where altered mucosal biology plays a crucial role. Our research aims to better understand this peptide family and its therapeutic potential for the treatment of gastrointestinal disorders.

三叶因子家族肽（TFF1、TFF2和TFF3）在保护、维持和修复胃肠道和乳腺癌信号通路中起关键作用。因此，它们具有治疗或预防多种与粘膜损伤相关的胃肠道疾病的治疗潜力。TFF肽共享一个保守的基序，包括三个二硫键，稳定一个明确的三环结构，让人想起三叶草。虽然已经描述了TFF肽的多种功能，但它们在分子水平上的机制仍然知之甚少。我们的工作集中在TFF成员的化学合成上，以克服该肽家族合成生产的公认瓶颈。这使我们能够评估假定的TFF受体和蛋白质伴侣及其在胃肠道疾病中这些肽的治疗潜力中的重要性，其中改变的粘膜生物学起着至关重要的作用。我们的研究旨在更好地了解这个肽家族及其治疗胃肠道疾病的治疗潜力。