Optimization of a behavioral intervention to increase physical activity in older adults living with HIV
优化行为干预以增加艾滋病毒感染者老年人的体力活动
基本信息
- 批准号:10693938
- 负责人:
- 金额:$ 68.86万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2027-08-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerometerAddressAffectAgeAgingBehavior TherapyBehavioralBehavioral ResearchCardiovascular DiseasesCaringChronicClassificationClinical TrialsCognitiveCognitive TherapyConduct Clinical TrialsCoping SkillsCounselingDataDevelopmentDiseaseElderlyEnrollmentEvaluationExerciseFatigueFriendsFutureGoalsGuidelinesHIVHealth BenefitHigh PrevalenceIndividualInterventionInterviewLifeLife StyleMediationMediatorMental DepressionMental HealthMental disordersModelingMonitorOutcomePainParticipantPersonsPhasePhenotypePhysical activityPreparationPrimary CarePrivatizationPublic HealthQuality of lifeRecommendationRefractoryResearchRiskRisk FactorsSocial supportSpecific qualifier valueTestingWalkingantiretroviral therapybrief advicecardiovascular disorder riskchronic painclinical riskcomorbiditydesignefficacy evaluationefficacy validationexercise interventionexperienceexperimental studyfitbitfrailtyhealthspanhuman old age (65+)improvedlifestyle factorsmultidisciplinarymultiphase optimization strategyphysical conditioningprimary outcomeprogramsrecruitsecondary outcomesocialtheoriestherapy development
项目摘要
Increasing numbers of persons living with HIV (PLWH) are living to older ages. Older PLWH are at increased
risk for a wide spectrum of co-morbid conditions such as cardiovascular disease, frailty phenotype, and mental
health disorders. Practical primary care-based interventions are needed for older PLWH that target lifestyle
factors to reduce complications of aging and improve healthspan. Most PLWH engage in less physical activity
(PA) than is recommended by public health guidelines. Thus, increasing PA can lead to numerous mental and
physical health benefits among PLWH. Current studies in PLWH typically focus on the impact of supervised
exercise. However, there are many barriers to this type of PA. Lifestyle physical activity (LPA) programs that
focus on integrating PA, especially walking, into everyday life, may be more successful in producing a
sustained increase in PA. The long-term goal of this research is to develop an effective and efficient primary
care intervention that increases LPA among older PLWH. We leverage the Multiphase Optimization STrategy
(MOST) as a framework for developing, optimizing, and evaluating a multicomponent behavioral intervention.
MOST is comprised of three phases. First, in the preparation phase, an empirical and theory-driven conceptual
model is developed that identifies differentiable intervention components and specifies optimization criteria
(i.e., goal of intervention development). We have completed this phase. Second, in the optimization phase, the
impact of each intervention component on the desired outcome is empirically examined. The goal is to
determine which components to include in a final intervention package that is optimized for efficacy and
efficiency. The proposed study reflects the second phase, or an optimization trial. Finally, in the evaluation
phase, the optimized intervention package is evaluated for efficacy in a traditional RCT; this will be the next
step in this line of research following the currently proposed project. In this project, we will test the impact of
three separable intervention components on steps per day after 4 months of intervention. We will recruit 208
PLWH of age ≥50 year classified as low-active. All participants receive component ‘0’: brief advice to exercise
and a Fitbit activity tracker. We then test 3 additional components in a factorial design: 1) PA Coaching—
focused on goal-setting and self-monitoring; 2) Cognitive-Behavioral intervention for PA (CB-PA)—focused on
identifying values and addressing internal barriers to PA such as pain, depression, or fatigue; 3) Social Support
for PA (SS-PA)—a component which leverages the social functionality of the Fitbit app, promoting social
support and friendly competition. The primary outcome will be steps per day during Month 4. The observed
main and interaction effects for the 3 candidate components will guide selection of components to be included
in an optimized intervention that will be tested in a future RCT. We will also examine potential mediators for
each intervention component, as well as secondary outcomes including perceived physical health, mental
health, cardiovascular disease risk, and the frailty phenotype.
越来越多的艾滋病毒感染者活到老年。老年PLWH增加
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jason V Baker其他文献
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{{ truncateString('Jason V Baker', 18)}}的其他基金
Immunologic basis of cardiac disease after severe COVID-19
重症COVID-19后心脏病的免疫学基础
- 批准号:
10442251 - 财政年份:2022
- 资助金额:
$ 68.86万 - 项目类别:
Immunologic basis of cardiac disease after severe COVID-19
重症COVID-19后心脏病的免疫学基础
- 批准号:
10650182 - 财政年份:2022
- 资助金额:
$ 68.86万 - 项目类别:
Optimization of a behavioral intervention to increase physical activity in older adults living with HIV
优化行为干预以增加艾滋病毒感染者老年人的体力活动
- 批准号:
10481551 - 财政年份:2022
- 资助金额:
$ 68.86万 - 项目类别:
Clinical and immunologic factors underlying heart failure with preserved ejection fraction among persons with HIV in South Africa
南非艾滋病毒感染者射血分数保留的心力衰竭的临床和免疫因素
- 批准号:
10325041 - 财政年份:2021
- 资助金额:
$ 68.86万 - 项目类别:
Clinical and immunologic factors underlying heart failure with preserved ejection fraction among persons with HIV in South Africa
南非艾滋病毒感染者射血分数保留的心力衰竭的临床和免疫因素
- 批准号:
10685376 - 财政年份:2021
- 资助金额:
$ 68.86万 - 项目类别:
PrEP iT! A Pilot Test of a Mobile Peer Support Intervention to Optimize PrEP Adherence and Retention in PrEP Care
PrEP iT!
- 批准号:
10116478 - 财政年份:2019
- 资助金额:
$ 68.86万 - 项目类别:
Treatment to reduce inflammation and improve immune recovery among older HIV pts
减少老年艾滋病患者炎症并改善免疫恢复的治疗
- 批准号:
8641495 - 财政年份:2014
- 资助金额:
$ 68.86万 - 项目类别:
Treatment to reduce inflammation and improve immune recovery among older HIV pts
减少老年艾滋病患者炎症并改善免疫恢复的治疗
- 批准号:
9038208 - 财政年份:2014
- 资助金额:
$ 68.86万 - 项目类别:
Treatment to reduce inflammation and improve immune recovery among older HIV pts
减少老年艾滋病患者炎症并改善免疫恢复的治疗
- 批准号:
8883185 - 财政年份:2014
- 资助金额:
$ 68.86万 - 项目类别:
Targeted anticoagulant therapy to reduce inflammation in treated HIV disease
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- 批准号:
8846913 - 财政年份:2014
- 资助金额:
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