Etiology and Outcomes of Meningitis in Rural, Northern Uganda
乌干达北部农村地区脑膜炎的病因和结果
基本信息
- 批准号:10693970
- 负责人:
- 金额:$ 16.26万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:Acquired Immunodeficiency SyndromeAdultAffectAfricaAfrica South of the SaharaAntifungal AgentsAntigensAreaBacteriaBacterial MeningitisBlindnessCaringCessation of lifeChildCommunicable DiseasesCountryCryptococcal MeningitisCryptococcusCryptococcus neoformansDiagnosisDisease OutbreaksEarly DiagnosisEducational workshopEpidemicEthiopiaEtiologyFreezingGenesGoalsGrantHIVHIV SeropositivityHealth PersonnelHealth care facilityHealthcareHospital ReferralsHospitalsHuman ResourcesHuman immunodeficiency virus testImpaired cognitionInfantInfrastructureJointsLaboratoriesLatex Fixation TestsManuscriptsMeasuresMeningitisMethodologyMicrobiologyMinnesotaNeurologicNeurologic DeficitNucleic Acid Amplification TestsOutcomePatient AdmissionPatientsPersonsPublic HealthQuality of lifeRehabilitation therapyReportingResource-limited settingRiskRuralSamplingSenegalServicesSigns and SymptomsTuberculosisUgandaUniversitiesVaccinesVirusYeastsantigen testantiretroviral therapydeafnessdesigndiagnostic valuedisabilityexperiencefungusglobal healthhearing impairmentimprovedimproved outcomelateral flow assaylong-term sequelaemortalitynext generation sequencingoutbreak controlprematurepreventprogramsroutine Bacterial stainstandard of caretreatment optimizationtreatment program
项目摘要
Our long-term goal is to improve outcomes from meningitis in rural, northern Uganda, an area within the
meningitis belt of Africa, where there has been poor infrastructure related to the diagnosis and management of
meningitis. Each year, approximately five million people worldwide are affected by meningitis. According to the
WHO, the estimated number of annual deaths related to meningitis is 300,000, with infants and children at
greatest risk. A global health initiative to defeat meningitis by 2030 was developed by the WHO and partners.
The key goals are to: a) eliminate epidemics of bacterial meningitis (BM), b) reduce cases and deaths from
vaccine-preventable BM, and c) reduce disability and improve quality of life. In 2017, we developed a CM
diagnosis and treatment program (CM-DTP) at Lira Regional Referral Hospital (LRRH) in rural, northern
Uganda as a quality improvement initiative designed to improve the diagnosis and treatment of CM. This
ongoing program is a joint effort by collaborators on this application: University of Minnesota (UMN), the
Infectious Diseases Institute (IDI) at Makerere University, and Lira University/LRRH. Through the CM-DTP,
patients admitted to LRRH with signs and symptoms of meningitis undergo rapid HIV testing, HIV-positive
patients then undergo rapid cryptococcal antigen (CrAg) testing, and patients diagnosed with CM receive
standard of care antifungal treatment. Although this program was effective at improving the diagnosis and
treatment of CM, the program also pointed out major gaps in meningitis care related to the diagnosis and
treatment of meningitis due etiologies other than CM. Of 281 adult patients who presented with meningitis at
LRRH from 2017 to 2019, we diagnosed CM in 99 (35.2%), but the etiology of meningitis for the other 64.8% of
patients was unknown, due to lack of diagnostic capabilities. The specific aims are directed at improving
infrastructure for the diagnosis and treatment of meningitis by building microbiology laboratory capacity,
directing treatments at etiologies, and educating health care workers. Aim 1 is to identify the etiology of
meningitis in 400 patients at LRRH through expanded microbiology laboratory capacity developed through this
grant, aim 2 is to direct treatment of patients with meningitis based on etiology, and for each etiology, track
outcomes including death, cognitive impairment and neurological deficits, and aim 3 is to build human
resources capacity among health care workers to identify, diagnose, and treat meningitis at LRRH, Lira
University, and surrounding health facilities. This project will build microbiology laboratory and human
resources capacity for the diagnosis and treatment of meningitis in Lira and will provide vital information about
the burden, etiology, and outcomes of meningitis in a setting that is representative of many resource-limited
regions in rural SSA. Building capacity to diagnose different etiologies of meningitis at Lira University/LRRH will
allow recognition of meningitis outbreaks in the area if they should occur and allow public health measures,
such as vaccines or mitigation efforts, to be implemented for outbreak control.
我们的长期目标是改善乌干达北部农村地区脑膜炎的治疗效果
项目成果
期刊论文数量(0)
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Paul R Bohjanen其他文献
Paul R Bohjanen的其他文献
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{{ truncateString('Paul R Bohjanen', 18)}}的其他基金
Etiology and Outcomes of Meningitis in Rural, Northern Uganda
乌干达北部农村地区脑膜炎的病因和结果
- 批准号:
10543219 - 财政年份:2022
- 资助金额:
$ 16.26万 - 项目类别:
Impact of HIV and HIV therapy on the Etiology and Outcome of Meningitis in Uganda
乌干达艾滋病毒和艾滋病毒治疗对脑膜炎病因和结果的影响
- 批准号:
7920491 - 财政年份:2010
- 资助金额:
$ 16.26万 - 项目类别:
Impact of HIV and HIV therapy on the Etiology and Outcome of Meningitis in Uganda
乌干达艾滋病毒和艾滋病毒治疗对脑膜炎病因和结果的影响
- 批准号:
8073433 - 财政年份:2010
- 资助金额:
$ 16.26万 - 项目类别:
HIV Immune Reconstitution Inflammatory Syndrome in Uganda
乌干达的艾滋病毒免疫重建炎症综合征
- 批准号:
7648233 - 财政年份:2008
- 资助金额:
$ 16.26万 - 项目类别:
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