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1/3 Morehouse School of Medicine/Tuskegee University/University of Alabama at Birmingham O'Neal Comprehensive Cancer Center Partnership

1/3 莫尔豪斯医学院/塔斯基吉大学/阿拉巴马大学伯明翰分校奥尼尔综合癌症中心合作伙伴关系

基本信息

批准号：
10693349
负责人：
UPENDER MANNE
金额：
$ 115.24万
依托单位：
MOREHOUSE SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-30 至 2026-08-31
项目状态：
未结题

项目摘要

OVERALL: PROJECT SUMMARY: (Overall is identical to all three partnering institutions) This type-2 application is to strengthen and build upon the established U54 Partnership between Morehouse School of Medicine (MSM), Tuskegee University (TU), and the UAB O’Neal Comprehensive Cancer Center (UAB OCCC). The Partnership, located in the heart of the Southeast, a region with a large, historically underserved, African American (AA) population, has the overall goal of attaining excellence in research focused on elimination of cancer health disparities and on reducing the cancer burden among underserved populations in the region. The partnering institutions possess distinctive strengths that complement each other in achieving the proposed goal through integrated research, education, and outreach. The primary objectives are to enhance productive cancer research programs, to develop a pipeline of racial/ethnic minority investigators in cancer research at MSM and TU, and to increase the level of involvement of investigators conducting research on cancer disparities at the UAB OCCC. The Partnership has four Cores (Administrative, Outreach, Research Education, and Planning & Evaluation); two Full Research Projects; one Pilot Research Project; and two Shared Resources (Bioethics and Biostatistics/Bioinformatics). With these assets and activities, the Partnership will: 1) through the two full projects, a) determine if amplification and overexpression of TRIP13 contribute to prostate cancer aggressiveness and progression and b) develop combination therapy strategies that modulate the immune microenvironment for colorectal cancers and identify alternative targets adaptable to personalized medicine. The overall objectives of the Pilot Project are to characterize factors associated with uptake of lung cancer screening (LCS) in two different health care systems and to explore barriers and facilitators to LCS at the system, provider, and patient levels that will inform the development of a multi-level intervention. 2) through the Outreach Core, implement and evaluate an evidence-based, theory-informed, multi-level, clinical trial and cancer genomics education program that addresses the determinants for AA and Latinx participation in clinical trials and cancer genomics studies; 3) through the Research Education Core, employ an integrated research education program that involves capacity building and linkages to high school, undergraduate and graduate/medical students, postdoctoral fellows, medical residents, and early-stage investigators, allowing them to pursue careers in cancer research; and 4) provide funding for additional Pilot Research projects. The Planning & Evaluation Core will continually assess/evaluate outcomes of the cores, research projects, and shared resources. The Bioethics Shared Resource will promote and ensure adherence to bioethical principles and address ethical considerations in relationships between the institutions and between the institutions and communities. The Biostatistics and Bioinformatics Shared Resource will deliver statistical and bioinformatics support for all activities. Together, these actions will contribute to elimination of cancer health disparities.

总体：项目摘要：（总体与所有三个合作机构相同）此 2 类申请旨在加强和建立 Morehouse 之间已建立的 U54 合作伙伴关系医学院 (MSM)、塔斯基吉大学 (TU) 和 UAB 奥尼尔综合癌症中心 (UAB) 奥委会）。该伙伴关系位于东南部的中心地带，该地区拥有大片、历史上服务不足的地区，非裔美国人 (AA) 人口的总体目标是在专注于消除的研究中取得卓越成就癌症健康差异以及减少该地区服务不足人群的癌症负担。合作机构拥有独特的优势，在实现拟议目标方面可以相互补充通过综合研究、教育和推广来实现这一目标。主要目标是提高生产力癌症研究计划，在癌症研究中开发种族/族裔少数研究人员的渠道 MSM 和 TU，并提高研究人员对癌症差异研究的参与程度在 UAB OCCC。该伙伴关系有四个核心（行政、外展、研究教育和规划与评估）；两个完整的研究项目；一项试点研究项目；和两个共享资源（生物伦理学和生物统计学/生物信息学）。凭借这些资产和活动，合作伙伴将： 1) 通过两个完整的项目，a) 确定 TRIP13 的扩增和过度表达是否会导致前列腺癌 b) 开发调节免疫的联合治疗策略结直肠癌的微环境并确定适合个性化医疗的替代靶点。这该试点项目的总体目标是确定与肺癌筛查相关的因素（LCS）在两个不同的医疗保健系统中，并探讨系统、提供者、以及患者水平，这将为多层次干预的发展提供信息。 2) 通过外展核心，实施和评估基于证据的、基于理论的、多层次的临床试验和癌症基因组学解决 AA 和拉丁裔参与临床试验和癌症的决定因素的教育计划基因组学研究； 3）通过研究教育核心，采用综合研究教育计划这涉及能力建设以及与高中、本科生和研究生/医学生的联系，博士后研究员、住院医生和早期研究人员，使他们能够从事癌症领域的职业研究; 4) 为额外的试点研究项目提供资金。规划与评估核心将持续评估核心成果、研究项目和共享资源。生物伦理学共享资源将促进并确保遵守生物伦理原则并解决伦理问题机构之间以及机构与社区之间的关系。生物统计学和生物信息学共享资源将为所有活动提供统计和生物信息学支持。一起，这些行动将有助于消除癌症健康差异。