2/3 Morehouse School of Medicine/Tuskegee University/ University of Alabama at Birmingham O'Neal Comprehensive Cancer Center Partnership

总体：项目概要：（总体与所有三个伙伴机构相同） 这种类型-2应用程序是为了加强和建立在建立U 54伙伴关系之间的莫尔豪斯 医学院（MSM），塔斯基吉大学（TU）和UAB奥尼尔综合癌症中心（UAB OCCC）。该伙伴关系位于东南部的中心地带，该地区面积大，历史上服务不足， 非洲裔美国人（AA）人口，有一个总体目标，实现卓越的研究重点是消除 本区域将继续努力消除癌症健康方面的差距，并减少本区域得不到充分服务的人口的癌症负担。 伙伴机构拥有独特的优势，在实现拟议的 通过综合研究，教育和推广实现目标。主要目标是提高生产力 癌症研究计划，在癌症研究中开发一个种族/少数民族研究人员的管道， MSM和TU，并提高研究人员对癌症差异研究的参与程度 在UAB OCCC。该伙伴关系有四个核心（行政、外联、研究教育和 规划与评估）;两个完整的研究项目;一个试点研究项目;和两个共享资源 （生物伦理学和生物统计学/生物信息学）通过这些资产和活动，伙伴关系将：1）通过 两个完整的项目，a）确定TRIP 13的扩增和过表达是否有助于前列腺癌 和B）开发调节免疫的联合治疗策略， 结肠直肠癌的微环境，并确定适应个性化医疗的替代目标。的 试点项目的总体目标是确定与肺癌筛查相关的因素 (LCS)在两个不同的医疗保健系统，并探讨系统，提供者， 和患者水平，这将为多层次干预的发展提供信息。2)通过外展核心， 实施和评估循证、理论指导、多层次临床试验和癌症基因组学 教育计划，解决AA和Latinx参与临床试验和癌症的决定因素 基因组学研究; 3）通过研究教育核心，采用综合研究教育计划 这涉及能力建设和与高中、本科和研究生/医科学生的联系， 博士后研究员、住院医师和早期研究人员，使他们能够从事癌症研究 （4）为其他试点研究项目提供资金。规划与评估核心将 持续评估/评价核心、研究项目和共享资源的成果。生物伦理 共享资源将促进和确保遵守生物伦理原则，并解决伦理问题 机构之间以及机构和社区之间的关系。生物统计学和 生物信息学共享资源将为所有活动提供统计和生物信息学支持。在一起， 这些行动将有助于消除癌症健康方面的差距。

OVERALL: PROJECT SUMMARY: (Overall is identical to all three partnering institutions) This type-2 application is to strengthen and build upon the established U54 Partnership between Morehouse School of Medicine (MSM), Tuskegee University (TU), and the UAB O’Neal Comprehensive Cancer Center (UAB OCCC). The Partnership, located in the heart of the Southeast, a region with a large, historically underserved, African American (AA) population, has the overall goal of attaining excellence in research focused on elimination of cancer health disparities and on reducing the cancer burden among underserved populations in the region. The partnering institutions possess distinctive strengths that complement each other in achieving the proposed goal through integrated research, education, and outreach. The primary objectives are to enhance productive cancer research programs, to develop a pipeline of racial/ethnic minority investigators in cancer research at MSM and TU, and to increase the level of involvement of investigators conducting research on cancer disparities at the UAB OCCC. The Partnership has four Cores (Administrative, Outreach, Research Education, and Planning & Evaluation); two Full Research Projects; one Pilot Research Project; and two Shared Resources (Bioethics and Biostatistics/Bioinformatics). With these assets and activities, the Partnership will: 1) through the two full projects, a) determine if amplification and overexpression of TRIP13 contribute to prostate cancer aggressiveness and progression and b) develop combination therapy strategies that modulate the immune microenvironment for colorectal cancers and identify alternative targets adaptable to personalized medicine. The overall objectives of the Pilot Project are to characterize factors associated with uptake of lung cancer screening (LCS) in two different health care systems and to explore barriers and facilitators to LCS at the system, provider, and patient levels that will inform the development of a multi-level intervention. 2) through the Outreach Core, implement and evaluate an evidence-based, theory-informed, multi-level, clinical trial and cancer genomics education program that addresses the determinants for AA and Latinx participation in clinical trials and cancer genomics studies; 3) through the Research Education Core, employ an integrated research education program that involves capacity building and linkages to high school, undergraduate and graduate/medical students, postdoctoral fellows, medical residents, and early-stage investigators, allowing them to pursue careers in cancer research; and 4) provide funding for additional Pilot Research projects. The Planning & Evaluation Core will continually assess/evaluate outcomes of the cores, research projects, and shared resources. The Bioethics Shared Resource will promote and ensure adherence to bioethical principles and address ethical considerations in relationships between the institutions and between the institutions and communities. The Biostatistics and Bioinformatics Shared Resource will deliver statistical and bioinformatics support for all activities. Together, these actions will contribute to elimination of cancer health disparities.