2/3 Morehouse School of Medicine/Tuskegee University/ University of Alabama at Birmingham O'Neal Comprehensive Cancer Center Partnership

总体情况：项目摘要：(总体情况与所有三个合作机构相同) 这一类型-2的应用是为了加强和建立莫尔豪斯之间建立的U54合作伙伴关系 医学院(MSM)、塔斯基吉大学(TU)和UAB O‘Neal综合癌症中心(UAB OCCC)。该伙伴关系位于东南部的心脏地带，这是一个拥有大量历史上服务不足的地区， 非洲裔美国人(AA)群体，总体目标是在专注于消除的研究中实现卓越 关于癌症健康差距和减少该区域未得到充分服务的人群中的癌症负担。 合作机构拥有独特的优势，在实现拟议的目标方面相辅相成。 通过综合研究、教育和推广实现这一目标。主要目标是提高生产力 癌症研究计划，在癌症研究中发展种族/少数民族研究人员管道 MSM和TU，并增加研究癌症差异的研究人员的参与程度 在UAB OCCC。该伙伴关系有四个核心(行政、外联、研究教育和 规划和评价)；两个完整的研究项目；一个试点研究项目；以及两个共享资源 (生物伦理学和生物统计学/生物信息学)。有了这些资产和活动，伙伴关系将：1)通过 两个完整的项目，a)确定TRIP13的扩增和过度表达是否与前列腺癌有关 侵袭性和进展性，以及b)开发调节免疫的联合治疗策略 为结直肠癌提供微环境，并确定适用于个性化药物的替代靶点。这个 试点项目的总体目标是确定与肺癌筛查相关的因素 (LCS)在两个不同的医疗保健系统中，并探索在系统、提供者、 以及患者水平，这将为多层次干预的发展提供信息。2)通过外联核心， 实施和评估循证、理论知情、多水平的临床试验和癌症基因组学 解决再生障碍性贫血和Latinx参与临床试验和癌症的决定因素的教育计划 基因组学研究；3)通过研究教育核心，采用综合研究教育计划 这涉及到能力建设以及与高中、本科生和研究生/医学生的联系， 博士后研究员、住院医师和早期调查人员，使他们能够从事癌症事业 研究；以及4)为更多的试点研究项目提供资金。规划与评估的核心意志 持续评估核心、研究项目和共享资源的成果。生命伦理学 共享资源将促进和确保遵守生物伦理原则，并解决伦理问题 在机构之间以及机构和社区之间的关系中。生物统计学和 生物信息学共享资源将为所有活动提供统计和生物信息学支持。一起， 这些行动将有助于消除癌症健康差距。

OVERALL: PROJECT SUMMARY: (Overall is identical to all three partnering institutions) This type-2 application is to strengthen and build upon the established U54 Partnership between Morehouse School of Medicine (MSM), Tuskegee University (TU), and the UAB O’Neal Comprehensive Cancer Center (UAB OCCC). The Partnership, located in the heart of the Southeast, a region with a large, historically underserved, African American (AA) population, has the overall goal of attaining excellence in research focused on elimination of cancer health disparities and on reducing the cancer burden among underserved populations in the region. The partnering institutions possess distinctive strengths that complement each other in achieving the proposed goal through integrated research, education, and outreach. The primary objectives are to enhance productive cancer research programs, to develop a pipeline of racial/ethnic minority investigators in cancer research at MSM and TU, and to increase the level of involvement of investigators conducting research on cancer disparities at the UAB OCCC. The Partnership has four Cores (Administrative, Outreach, Research Education, and Planning & Evaluation); two Full Research Projects; one Pilot Research Project; and two Shared Resources (Bioethics and Biostatistics/Bioinformatics). With these assets and activities, the Partnership will: 1) through the two full projects, a) determine if amplification and overexpression of TRIP13 contribute to prostate cancer aggressiveness and progression and b) develop combination therapy strategies that modulate the immune microenvironment for colorectal cancers and identify alternative targets adaptable to personalized medicine. The overall objectives of the Pilot Project are to characterize factors associated with uptake of lung cancer screening (LCS) in two different health care systems and to explore barriers and facilitators to LCS at the system, provider, and patient levels that will inform the development of a multi-level intervention. 2) through the Outreach Core, implement and evaluate an evidence-based, theory-informed, multi-level, clinical trial and cancer genomics education program that addresses the determinants for AA and Latinx participation in clinical trials and cancer genomics studies; 3) through the Research Education Core, employ an integrated research education program that involves capacity building and linkages to high school, undergraduate and graduate/medical students, postdoctoral fellows, medical residents, and early-stage investigators, allowing them to pursue careers in cancer research; and 4) provide funding for additional Pilot Research projects. The Planning & Evaluation Core will continually assess/evaluate outcomes of the cores, research projects, and shared resources. The Bioethics Shared Resource will promote and ensure adherence to bioethical principles and address ethical considerations in relationships between the institutions and between the institutions and communities. The Biostatistics and Bioinformatics Shared Resource will deliver statistical and bioinformatics support for all activities. Together, these actions will contribute to elimination of cancer health disparities.