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Pilot Project #1

试点项目

基本信息

批准号：
8849780
负责人：
UPENDER MANNE
金额：
$ 4.48万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-23 至 2018-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8849780
关键词：
Abnormal Erythroblast Actins Adenocarcinoma Adhesions Aggressive behavior Alabama Binding Cell Adhesion Molecules Cell Differentiation process Cell Proliferation Cell Shape Cell division Cell membrane Cell-Cell Adhesion Cells Characteristics Clinical Clinical Research Collaborations Colorectal Cancer Communities Comprehensive Cancer Center Cytoskeleton Data Development Differentiation and Growth Disease Embryonic Development Erythroblasts Erythroid Evaluation Extracellular Matrix Focal Adhesions Gene Proteins Gene Targeting Goals Homeostasis Human Immunologic Surveillance Integrins Laboratories Lead Lesion Link Malignant - descriptor Malignant Neoplasms Manuscripts Membrane Mentors Mentorship Metastatic Carcinoma Minority-Serving Institution Molecular Molecular Target Neoplasm Metastasis Nuclear Matrix Organism Outcome Pathologic Pathway interactions Phagocytosis Pilot Projects Population Heterogeneity Predictive Value Premalignant Process Proteins Publishing Recurrence Research Research Personnel Research Training Role Signal Pathway Signal Transduction Staging Technology Testing Tissues Training and Education Treatment Efficacy Universities University of Alabama at Birmingham Cancer Center Vision Wound Healing adenoma anticancer research base cancer health disparity career cell growth cell motility directional cell experience extracellular macrophage metastatic colorectal migration monocyte peripheral blood pre-clinical preclinical study prognostic protein complex racial and ethnic research study therapeutic target translational study tumor tumor microenvironment tumor progression

项目摘要

SUMMARY The primary goal of this preclinical translational proposal is to determine the role of erythroblast macrophage protein (Emp) in tumor progression and to establish its prognostic and predictive value for colorectal cancers (CRCs). In our published and preliminary studies, we have discovered that Emp is involved in erythroblast enucleation, macrophage development, cell growth and differentiation, and cell adhesion and migration. These pathways are hallmarks of cancer progression. Additionally, our preliminary immunohistochemical (IHC) evaluations of human CRC tissues have demonstrated increasing expression of Emp in progression of adenomas to primary adenocarcinomas to metastatic carcinomas. Therefore, we hypothesize that Emp is involved in CRC progression. To test this hypothesis, we propose to evaluate the role of Emp interactions with adhesion molecules for attachment to extracellular membranes (ECM), for molecular cross-talk, for effects on the tumor microenvironment, and for progression of CRCs. This will be accomplished in three aims. Aim-1 will determine the interaction of Emp with β1 integrin within focal adhesion plaques and its involvement in tumor progression; Aim-2 will verify the interaction of Emp with the actin cytoskeleton in ECM functions and in metastasis; and Aim-3 will establish the prognostic and predictive value of Emp in CRCs. The proposed studies will characterize the molecular interactions of Emp with β1 integrin, ascertain the effects of Emp on the actin cytoskeleton and other components of the ECM, identify new molecular determinants that contribute to tumor progression, and assess the predictive and prognostic value of Emp in CRCs.

总结