Developmental Research Program

发展研究计划

• 批准号: 10708579
• 负责人: Ryan C Fields
• 金额: $ 23.02万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-28 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10708579
• 关键词: Area; Award; Cancer Biology; Cancer Research Project; Clinical; Clinical Trials; Collaborations; Development; Disabled Persons; Early Diagnosis; Epidemiology; Extramural Activities; Faculty; Fostering; Funding; Future; Goals; Grant; Group Meetings; Image; Institution; Malignant Neoplasms; Malignant neoplasm of pancreas; Mentors; Minority; Minority Groups; Minority Recruitment; Peer Review; Prevention; Program Research Project Grants; Refractory; Research; Research Personnel; Research Project Grants; Translating; Translational Research; Underrepresented Minority; Universities; Washington; Woman; Work; Writing; anticancer research; cancer prevention; career; design; improved; innovation; meetings; minority investigator; pancreas development; pancreatic cancer patients; programs; recruit; success

PROJECT SUMMARY The goal of the SPORE in Pancreatic Cancer Developmental Research Program (DRP) is to recruit and support developmental research projects in pancreatic cancer for future incorporation as full SPORE projects or as the basis for applications for other nationally competitive peer-reviewed funding. The types of pancreatic cancer research projects that will be supported include basic, translational, clinical, epidemiologic, and cancer prevention. Projects supported under the DRP will expand the scope of translational research and increase the number of investigators committed to pancreatic cancer research. The DRP is open to institutions participating in the SPORE (WUSM, UPenn) and any of their collaborators. The DRP will work in tandem with the Career Enhancement Program (CEP) to assist in developing junior investigators and recruiting/mentoring minority investigators. These objectives will be accomplished by performing four specific aims. Aim 1: Support the development of pancreatic cancer research projects for future incorporation as full SPORE projects or for new independent peer-reviewed funding. The DRP will solicit new research projects annually. In addition to NCI funds, a total of $375,000 in institutional support has been committed in support of the DRP. DRP awards will provide up to $75,000 for 1 year, with a competitive renewal allowed for a second year of funding. Two to three awards per year are anticipated. Institutional funds will make the NCI funds ($25,000/year) committed to underrepresented minorities equivalent to other DRP awards. Aim 2: Foster collaborations between basic and clinical researchers. The DRP directors will facilitate interactions between basic and clinical researchers through shared weekly meetings, the annual SPORE retreat, and small group meetings. Aim 3: Mentor junior faculty and new faculty involved in pancreatic cancer research. All investigators submitting applications to the DRP will receive a written scientific and statistical review, and the DRP directors will be available to discuss the projects in detail. Where appropriate, mentors will be identified to work with junior faculty or collaborate with faculty whose primary research area is outside of pancreatic cancer. All DRP awardees will present their research progress to the SPORE steering committee twice per year. Aim 4: Promote the participation of women, minorities, and disabled investigators in pancreatic cancer research and facilitate the recruitment of minorities into clinical pancreatic cancer trials. The DRP directors will implement initiatives that enhance the participation of women, minorities, and disabled persons in SPORE clinical trials and promote the participation of diverse groups in pancreatic cancer research. Impact: The proposed work will improve our understanding of pancreatic cancer biology and will identify new strategies for early detection, prevention, imaging, and treatment for this refractory malignancy.

项目总结 胰腺癌发展研究计划(DRP)中孢子的目标是招募和支持 胰腺癌的发展研究项目，将来作为全孢子项目或作为 申请其他具有国家竞争力的同行审查资金的基础。胰腺癌的类型 将支持的研究项目包括基础研究、转化研究、临床研究、流行病学研究和癌症研究 预防。DRP支持的项目将扩大翻译研究的范围，并增加 致力于胰腺癌研究的研究人员数量。DRP对参与的机构开放 在孢子(WUSM，UPenn)及其任何合作者中。DRP将与职业生涯同步工作 加强计划(CEP)，以协助发展初级调查人员和招募/指导少数族裔 调查人员。这些目标将通过实现四个具体目标来实现。 目标1：支持胰腺癌研究项目的发展，以便将来完全纳入 孢子项目或新的独立同行审查资金。DRP将征集新的研究项目 每年一次。除了NCI基金外，还承诺提供总计375,000美元的机构支助，以支持 DRP。DRP奖励将提供为期一年的最高75,000美元，并允许第二次竞争续签 一年的资金。预计每年将有两到三个奖项。机构资金将使NCI基金 (25,000美元/年)承诺向代表不足的少数群体提供相当于其他DRP奖的奖励。 目标2：促进基础和临床研究人员之间的合作。民防局长将协助 基础和临床研究人员之间的互动通过共享的每周会议、年度孢子静修、 和小组会议。 目标3：指导参与胰腺癌研究的初级教员和新教员。所有调查人员 向DRP提交申请将收到书面的科学和统计审查，DRP主任 将可以详细讨论这些项目。在适当的情况下，将指定导师与初级教师一起工作 或与主要研究领域不在胰腺癌领域的教师合作。所有DRP获奖者 将每年两次向孢子指导委员会报告他们的研究进展。 目标4：促进妇女、少数民族和残疾研究人员参与胰腺癌研究 研究和促进招募少数族裔参加胰腺癌临床试验。《DRP》 董事们将实施倡议，加强妇女、少数群体和残疾人在 孢子临床试验，促进不同群体参与胰腺癌研究。 影响：拟议的工作将提高我们对胰腺癌生物学的理解，并将发现新的 早期发现、预防、成像和治疗这种难治性恶性肿瘤的策略。