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Development of remotely actuated deformable membranes for in situ mechanical testing of soft tissue

开发用于软组织原位机械测试的远程致动变形膜

基本信息

批准号：
10708754
负责人：
Andres Arrieta Diaz
金额：
$ 18.17万
依托单位：
PURDUE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-23 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10708754
关键词：
3-Dimensional Acute Algorithms Animal Disease Models Animal Model Animals Architecture Basic Science Big Data Biomechanics Biomedical Engineering Biomedical Research Chronic Cicatrix Complex Computer software Connective and Soft Tissue Contracture Data Data Set Dermal Development Devices Diagnostic Disease Disease Progression Elements Environment Exhibits Frequencies Future Goals Health Human Hypertrophic Cicatrix Implant In Situ Investigation Liver Liver Fibrosis Magnetic Resonance Imaging Magnetism Measurement Measures Mechanics Membrane Methods Modeling Monitor Mus Onset of illness Organ Output Parameter Estimation Pathology Pattern Physiological Process Property Reconstructive Surgical Procedures Research Residual state Skin Stress Structure Technology Testing Thinness Tissue Expansion Tissue Sample Tissues Validation Vision Work biocompatible polymer data-driven model imaging modality implantable device improved in vivo kinematics machine learning model magnetic field mechanical behavior mechanical properties new technology non-invasive imaging novel particle response simulation soft tissue technology development technology validation tissue phantom tissue stress tool ultrasound

项目摘要

Project Summary Soft connective tissues have remarkable mechanical functions, operating in the large deformation regime, showing highly nonlinear stress-strain response, and being physiologically under residual stress. Dysregulation of the tissue homeostatic state is associated with pathology, such as hypertrophic scar contracture and liver fibrosis. Progress in imaging modalities has opened a window into tissue kinematics in vivo in health and disease, for example high frequency ultrasound. Yet, measurement of mechanical properties in vivo remains out of reach. The state of the art in biomedical research remains ex vivo mechanical tests, which hinders progress in basic biomedical research towards understanding how tissues adapt mechanically in health and disease. Thus, for accurate measurement of the physiological mechanical environment of soft tissues, to better understand biomechanics of disease onset and progression, and eventually to improve diagnostics and treatment based on the evolving mechanics of soft tissue, new tools to measure mechanical properties in vivo are urgently needed. The objective of this proposal is to develop a novel remotely actuated deformable membrane to perform mechanical tests of soft tissue in vivo. We will develop a remotely actuated membrane capable of locally applying controlled stress fields to underlying tissue and measuring the ensuing deformation with high frequency ultrasound (Aim 1); develop a data-driven model of an active membrane adhered to a soft deformable substrate to enable parameter estimation from complex stress-strain data (Aim 2); and validate the technology on tissue phantoms, and murine skin and liver tissues ex vivo and in vivo (Aim 3). The work proposed here will result in a new technology to do in vivo mechanical tests of soft tissue, enabling progress of basic research in biomedical engineering. Development of this technology will open new possibilities to monitoring tissue mechanics in animal models of disease, expanding the current paradigm of kinematic tracking only. Our future work will continue in the direction of our long-term goal, towards development of implantable devices based on the same core technology proposed here.

项目总结