Developmental Research Program

发展研究计划

• 批准号: 10708758
• 负责人: Jason S. Lewis
• 金额: $ 11.08万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10708758
• 关键词: Award; Clinical Trials; Collaborations; Combined Modality Therapy; Data; Development; Doctor of Philosophy; Eligibility Determination; Extramural Activities; Faculty; Funding; Genomics; Goals; Immunotherapeutic agent; Individual; Institution; Investigation; Islet Cell Tumor; Leadership; Malignant neoplasm of pancreas; Memorial Sloan-Kettering Cancer Center; Outcome; Pancreas; Participant; Patient Care; Peer Review; Pilot Projects; Program Research Project Grants; Publications; Qualifying; Recording of previous events; Request for Proposals; Research; Research Personnel; Research Support; Resources; Translational Research; Underrepresented Populations; United States National Institutes of Health; Universities; Vision; Women' s Group; anticancer research; base; biomarker development; clinical care; diversity and inclusion; innovation; medical schools; novel strategies; pancreatic neoplasm; preference; programs; radiomics; stem; success; translational cancer research; translational goal

PROJECT SUMMARY/ABSTRACT – DRP The goals of the Developmental Research Program (DRP) of the MSK Pancreas SPORE are to expand the breadth of the translational pancreatic cancer research base and to encourage highly innovative investigations that have major potential to impact pancreatic cancer outcomes. DRP funds, supplemented by institutional funds, will allow us to support 2 exceptional pilot projects each year. We will request proposals for pilot projects with a clear translational focus and with potential to ultimately impact clinical care of patients with pancreatic neoplasms. Investigators (MD, MD/PhD, DO, or PhD) with a demonstrated history of pancreas cancer research appointed at MSK or a neighboring institution, Weill Cornell Medical College and the Rockefeller University, will be eligible to apply. Applications will be peer-reviewed by the CEP/DRP Selection Committee, which is composed of the SPORE PIs, DRP and CEP Leaders, select MSK Departmental and Divisional Chairs, and representatives from the MSK Equality, Diversity & Inclusion Council. The most meritorious projects based on defined review criteria will be selected. Preference will be given to projects that advance the long-term research goals of the SPORE and have high potential to become full SPORE projects. We will prioritize projects submitted by early-stage investigators and are committed to promoting diversity and strengthening the participation of women and underrepresented groups in translational research. DRP awardees will have full access to SPORE Core resources, will benefit from the expertise of the SPORE investigative team, and will be active participants in the SPORE. The scientific progress of DRP projects will be evaluated every six months by the DRP Leaders. Long-term metrics of success for DRP awardees include presentation/publication of original research, successful competition for independent research support, successful development and completion of clinical trials stemming from DRP research, establishment of new collaborations, and institutional recognition by academic promotion. DRP projects that make significant progress towards their translational goals will be eligible for a second year of funding and have the potential to be promoted to full SPORE projects.

项目摘要/摘要 – DRP MSK 胰腺 SPORE 发展研究计划 (DRP) 的目标是扩大 转化胰腺癌研究基础的广度并鼓励高度创新的研究 具有影响胰腺癌结果的巨大潜力。 DRP资金，以机构资金为补充， 将使我们能够每年支持 2 个特殊的试点项目。我们将征求试点项目的建议 明确的转化重点，并有可能最终影响胰腺癌患者的临床护理 肿瘤。具有胰腺癌研究历史的研究人员（MD、MD/PhD、DO 或 PhD） 由 MSK 斯隆或邻近机构、威尔康奈尔医学院和洛克菲勒大学任命，将 有资格申请。申请将由 CEP/DRP 遴选委员会进行同行评审，该委员会是 由 SPORE PI、DRP 和 CEP 领导人组成，选出 MSK 部门和分部主席，以及 MSK 斯隆平等、多元化和包容性委员会的代表。最有价值的项目基于 将选择定义的审查标准。将优先考虑推进长期研究的项目 SPORE 的目标，并且有很大潜力成为完整的 SPORE 项目。我们将优先考虑提交的项目 由早期研究人员负责，并致力于促进多样性并加强参与者的参与 转化研究中的女性和代表性不足的群体。 DRP 获奖者将拥有 SPORE 的完全访问权限 核心资源，将受益于SPORE调查团队的专业知识，并将是积极的参与者 在孢子里。 DRP 领导者每六个月对 DRP 项目的科学进展进行评估。 DRP 获奖者成功的长期衡量标准包括原创研究的展示/出版、成功 独立研究支持、成功开发和完成临床试验的竞争 来自 DRP 研究、建立新的合作以及学术界的机构认可 晋升。在实现转化目标方面取得重大进展的 DRP 项目将有资格获得 资助的第二年，并有可能晋升为完整的 SPORE 项目。