Development of Degradable Fibers with Hemostatic Properties

项目摘要 止血材料领域的最新进展集中于开发具有高止血活性的产品。 效率理想的止血材料应快速控制止血，表现出生物相容性， 可降解性，促进伤口愈合，并且重量轻且便宜。静电纺丝降解 胶原蛋白、壳聚糖、聚己内酯等大分子产生的纳米纤维在伤口治疗中显示出希望 愈合和止血应用。现代止血治疗应具有可降解和 再生能力，但很少有研究已经公布的利用合成类似物，以昂贵的 生物分子该项目的长期目标是更好地了解聚合物基 止血伤口愈合材料和对这些材料的细胞反应， 再生治疗 作为实现这一目标的一个步骤，必须合成可降解的胶原蛋白链类似物，静电纺丝， 与其他支架相比，用于体外和体内评价。据推测，仿生合成 聚合物可以电纺成负担得起的、生物相容的、可降解的止血伤口敷料材料 不仅能催化凝血而且不需要手术切除 该提议是重要的，因为它代表了第一次尝试将聚酯基聚合物引入到聚合物中。 具有控制支架组成以联合收割机结合所需的能力 是伤口愈合和止血应用的理想材料。这种方法 是创新的，因为它将确定在应用中利用合成胶原模拟物的可行性， 作为电纺伤口愈合和止血材料。预计胶原样蛋白 新型聚酯上的官能团与纤维中壳聚糖的存在相结合将导致 在伤口模型中以适当的降解速率止血。此外，本科生将 进行本提案中的大部分研究。这将是一个重要的研究经验，为这些 学生，并将为他们提供宝贵的实验室和研究技能，这将是必不可少的， careers.

PROJECT SUMMARY Recent evolutions in the field of hemostatic materials have focused on developing products with high hemostatic efficiency. An ideal hemostatic material should quickly control hemorrhaging, exhibit biocompatibility and degradability, promote wound healing and be lightweight and inexpensive. Electrospinning degradable macromolecules like collagen, chitosan, polycaprolactone yields nanofiber which have shown promise in wound healing and bleeding cessation applications. Modern bleeding cessation treatments should have degradable and regenerative capabilities but little research has been published on the utilization of synthetic analogs to costly biomolecules. The long-term goal of this project is to generate a better understanding of polymer-based hemostatic wound healing materials and cellular responses towards these materials for implementation in regenerative treatments. As a step towards this goal, a degradable collagen strand analog must be synthesized, electrospun, and compared to other scaffolds for in vitro and in vivo evaluation. It is hypothesized that a biomimetic synthetic polymer can be electrospun into an affordable, biocompatible, degradable, hemostatic wound dressing material that will not only catalyze coagulation but also will not require surgical removal. This proposal is significant because it represents the first attempt to incorporate a polyester-based collagen mimic into electrospun scaffolds with the ability to control scaffold composition to combine desired properties and functionalities in an ideal material for wound healing and hemostatic applications. This approach is innovative because it will determine the feasibility of utilizing a synthetic collagen mimic in applications such as electrospun wound healing and bleeding cessation materials. It is anticipated that the collagen-like functional groups on the novel polyester coupled with the presence of chitosan in the fibers will lead to bleeding cessation in wound models with suitable degradation rates. Furthermore, undergraduate students will conduct the majority of the research in this proposal. This will be a significant research experience for these students and will provide them with valuable laboratory and research skills that will be essential in their careers.