Administrative and Coordination Core

项目摘要管理(ADMIN)核心 印第安纳大学(IU)/杰克逊实验室(JAX)/密歇根大学行政(管理)核心 匹兹堡(PITT)迟发性阿尔茨海默病中心模型生物体的开发与评价 (IU/JAX/PITT模型-AD)，由IU的行政主管Bruce Lamb博士领导，并得到多个 首席调查员保罗·特雷托博士和禤浩焯·奥布拉克博士，格雷格·卡特博士，加雷斯·豪厄尔博士， JAX的Mike Sasner、PIT的Stacey Rizzo博士和Sage Bionetworks的Anna Greenwood博士 在IU和JAX的项目联合经理和全职管理员的支持下，将监督所有 中心的行政和科学职能。管理核心将执行这些职责 来自外部咨询委员会(EAB)的监督，该委员会由该领域的领先专家和一个中心组成 由IU/JAX/PIT和UCI模型组成的指导委员会(CSC)-AD中心绩效指标和NIH计划 官员们。EAB每年召开一次，CSC每月召开一次，整个Model-AD联盟每月召开一次 审查进展并提供意见和反馈(口头和书面)，以确保中心(1)实现 它的使命、目标、里程碑和指标；(2)协调两个模型-AD中心的工作；(3) 有效地处理任何意想不到的问题或关切；以及(4)适应可能的试验性和 该领域的技术进步。将有两周一次的行政、BDMC、DMP和PTC会议，并联合 BDMC/DMP会议。这些活动将侧重于特定核心/项目所特有的问题，同时确保 Iu/JAX/PITT模型-AD中心各组成部分之间的最大协同作用。亲密互动 将在BDMC、PTC和DMP之间进行培养，从而促进及时发现，同时减少 总成本。管理核心的主要目标之一将是确保在一个 中心的面积将使中心整体受益，从而提高时间和成本效率。最后，管理员 CORE还将促进中心与其他正在进行的研究工作的互动和会议 阿尔茨海默病研究社区，包括NIA支持的ADRC，阿尔茨海默病 神经成像倡议(ADNI)，阿尔茨海默病加速医学伙伴关系(AMP-AD)， 以及加速阿尔茨海默病(Treat-AD)治疗发展的目标实现 财团。 IU/JAX/PITT模式-AD管理核心的具体目标如下： 1.提供有成效和高效率的管理、监督和评价国际货币基金组织/日本宇宙航空研究开发组织/皮特项目 模型-AD中心及其与AD研究社区的互动。 2.确保及时和成功地完成所有项目和核心目标和里程碑。 3.促进生物信息学和数据管理核心之间的互动 临床前测试核心和疾病模型项目。

PROJECT SUMMARY ADMINISTRATIVE (ADMIN) CORE The Administration (ADMIN) Core of the Indiana University (IU)/Jackson Laboratory (JAX)/University of Pittsburgh (PITT) Model Organism Development and Evaluation for Late-onset Alzheimer’s Disease Center (IU/JAX/PITT MODEL-AD), led by ADMIN Head Dr. Bruce Lamb at IU with assistance from multiple Principle Investigators (mPIs) Drs. Paul Territo and Adrian Oblak at IU, Drs. Greg Carter, Gareth Howell, and Mike Sasner at JAX, Dr. Stacey Rizzo at PITT, and Dr. Anna Greenwood at Sage Bionetworks and with the support of Program Co-Managers and full-time administrators at both IU and JAX, will oversee all administrative and scientific functions of the Center. The ADMIN Core will execute these duties with oversight from an External Advisory Board (EAB) comprising leading experts in the field and a Center Steering Committee (CSC) comprising IU/JAX/PITT and UCI MODEL-AD Center PIs and NIH program officials. The EAB will convene annually, the CSC monthly, and the entire MODEL-AD consortium monthly to review progress and provide input and feedback (oral and written) to ensure that the Center (1) achieves its mission, aims, milestones, and metrics; (2) coordinates efforts across the two MODEL-AD Centers; (3) effectively deals with any unanticipated problems or concerns; and (4) adapts to likely experimental and technical advances in the field. There will be biweekly ADMIN, BDMC, DMP, and PTC meetings and joint BDMC/DMP meetings. These will be focused on issues unique to specific Cores/Projects while ensuring maximal synergy among the various components of the IU/JAX/PITT MODEL-AD Center. Close interaction will be fostered among the BDMC, PTC, and the DMP, thus facilitating timely discoveries while reducing overall costs. One of the primary goals of the ADMIN Core will be to ensure that discoveries made in one area of the Center will benefit the Center overall, leading to efficiencies in time and cost. Finally, the ADMIN Core will also promote Center interactions and meetings with other ongoing research efforts in the Alzheimer’s research community, including the NIA-supported ADRCs, the Alzheimer’s Disease Neuroimaging Initiative (ADNI), the Alzheimer’s Disease Accelerating Medicine’s Partnership (AMP-AD), and the Target Enablement to Accelerate Therapy Development for Alzheimer’s Disease (TREAT-AD) consortium. The Specific Aims of the IU/JAX/PITT MODEL-AD ADMIN Core are as follows: 1. Provide effective and efficient management, oversight, and evaluation of the IU/JAX/PITT MODEL-AD Center and its interactions with the AD research community. 2. Ensure timely and successful completion of all Project and Core aims and milestones. 3. Facilitate interactions between and among the Bioinformatics and Data Management Core, the Preclinical Testing Core, and the Disease Model Project.