Administrative and Coordination Core

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PROJECT SUMMARY ADMINISTRATIVE (ADMIN) CORE The Administration (ADMIN) Core of the Indiana University (IU)/Jackson Laboratory (JAX)/University of Pittsburgh (PITT) Model Organism Development and Evaluation for Late-onset Alzheimer’s Disease Center (IU/JAX/PITT MODEL-AD), led by ADMIN Head Dr. Bruce Lamb at IU with assistance from multiple Principle Investigators (mPIs) Drs. Paul Territo and Adrian Oblak at IU, Drs. Greg Carter, Gareth Howell, and Mike Sasner at JAX, Dr. Stacey Rizzo at PITT, and Dr. Anna Greenwood at Sage Bionetworks and with the support of Program Co-Managers and full-time administrators at both IU and JAX, will oversee all administrative and scientific functions of the Center. The ADMIN Core will execute these duties with oversight from an External Advisory Board (EAB) comprising leading experts in the field and a Center Steering Committee (CSC) comprising IU/JAX/PITT and UCI MODEL-AD Center PIs and NIH program officials. The EAB will convene annually, the CSC monthly, and the entire MODEL-AD consortium monthly to review progress and provide input and feedback (oral and written) to ensure that the Center (1) achieves its mission, aims, milestones, and metrics; (2) coordinates efforts across the two MODEL-AD Centers; (3) effectively deals with any unanticipated problems or concerns; and (4) adapts to likely experimental and technical advances in the field. There will be biweekly ADMIN, BDMC, DMP, and PTC meetings and joint BDMC/DMP meetings. These will be focused on issues unique to specific Cores/Projects while ensuring maximal synergy among the various components of the IU/JAX/PITT MODEL-AD Center. Close interaction will be fostered among the BDMC, PTC, and the DMP, thus facilitating timely discoveries while reducing overall costs. One of the primary goals of the ADMIN Core will be to ensure that discoveries made in one area of the Center will benefit the Center overall, leading to efficiencies in time and cost. Finally, the ADMIN Core will also promote Center interactions and meetings with other ongoing research efforts in the Alzheimer’s research community, including the NIA-supported ADRCs, the Alzheimer’s Disease Neuroimaging Initiative (ADNI), the Alzheimer’s Disease Accelerating Medicine’s Partnership (AMP-AD), and the Target Enablement to Accelerate Therapy Development for Alzheimer’s Disease (TREAT-AD) consortium. The Specific Aims of the IU/JAX/PITT MODEL-AD ADMIN Core are as follows: 1. Provide effective and efficient management, oversight, and evaluation of the IU/JAX/PITT MODEL-AD Center and its interactions with the AD research community. 2. Ensure timely and successful completion of all Project and Core aims and milestones. 3. Facilitate interactions between and among the Bioinformatics and Data Management Core, the Preclinical Testing Core, and the Disease Model Project.