Administrative and Coordination Core

行政及协调核心

• 批准号: 10590446
• 负责人: Bruce T Lamb
• 金额: $ 63.4万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10590446
• 关键词: Accounting; Achievement; Administrative Coordination; Administrator; Alzheimer' s Disease; Alzheimer' s disease model; Animal Model; Area; Benchmarking; Bioinformatics; Biological Assay; Communication; Communities; Data; Development; Disease model; Ensure; Evaluation; Extramural Activities; Feedback; Fostering; Funding; Generations; Goals; Grant; Head; Indiana; Joints; Laboratories; Late Onset Alzheimer Disease; Leadership; Measures; Medicine; Mission; Modeling; Monitor; Oral; Peer Review; Preclinical Testing; Progress Reports; Publications; Recommendation; Reporting; Research; Research Personnel; Resources; Staging; Time; TimeLine; United States National Institutes of Health; Universities; Update; Work; base; cost; data management; data standards; data structure; improved; meetings; member; neuroimaging; operation; programs; success; synergism; therapy development; uptake

PROJECT SUMMARY ADMINISTRATIVE (ADMIN) CORE The Administration (ADMIN) Core of the Indiana University (IU)/Jackson Laboratory (JAX)/University of Pittsburgh (PITT) Model Organism Development and Evaluation for Late-onset Alzheimer’s Disease Center (IU/JAX/PITT MODEL-AD), led by ADMIN Head Dr. Bruce Lamb at IU with assistance from multiple Principle Investigators (mPIs) Drs. Paul Territo and Adrian Oblak at IU, Drs. Greg Carter, Gareth Howell, and Mike Sasner at JAX, Dr. Stacey Rizzo at PITT, and Dr. Anna Greenwood at Sage Bionetworks and with the support of Program Co-Managers and full-time administrators at both IU and JAX, will oversee all administrative and scientific functions of the Center. The ADMIN Core will execute these duties with oversight from an External Advisory Board (EAB) comprising leading experts in the field and a Center Steering Committee (CSC) comprising IU/JAX/PITT and UCI MODEL-AD Center PIs and NIH program officials. The EAB will convene annually, the CSC monthly, and the entire MODEL-AD consortium monthly to review progress and provide input and feedback (oral and written) to ensure that the Center (1) achieves its mission, aims, milestones, and metrics; (2) coordinates efforts across the two MODEL-AD Centers; (3) effectively deals with any unanticipated problems or concerns; and (4) adapts to likely experimental and technical advances in the field. There will be biweekly ADMIN, BDMC, DMP, and PTC meetings and joint BDMC/DMP meetings. These will be focused on issues unique to specific Cores/Projects while ensuring maximal synergy among the various components of the IU/JAX/PITT MODEL-AD Center. Close interaction will be fostered among the BDMC, PTC, and the DMP, thus facilitating timely discoveries while reducing overall costs. One of the primary goals of the ADMIN Core will be to ensure that discoveries made in one area of the Center will benefit the Center overall, leading to efficiencies in time and cost. Finally, the ADMIN Core will also promote Center interactions and meetings with other ongoing research efforts in the Alzheimer’s research community, including the NIA-supported ADRCs, the Alzheimer’s Disease Neuroimaging Initiative (ADNI), the Alzheimer’s Disease Accelerating Medicine’s Partnership (AMP-AD), and the Target Enablement to Accelerate Therapy Development for Alzheimer’s Disease (TREAT-AD) consortium. The Specific Aims of the IU/JAX/PITT MODEL-AD ADMIN Core are as follows: 1. Provide effective and efficient management, oversight, and evaluation of the IU/JAX/PITT MODEL-AD Center and its interactions with the AD research community. 2. Ensure timely and successful completion of all Project and Core aims and milestones. 3. Facilitate interactions between and among the Bioinformatics and Data Management Core, the Preclinical Testing Core, and the Disease Model Project.

项目摘要行政（admin）核心 印第安纳大学（IU）/杰克逊实验室（JAX）/大学的行政部门（管理）核心/大学 匹兹堡（PITT）模型组织的发展和评估阿尔茨海默氏病中心 （IU/jax/pitt model-ad），由Admin负责人Bruce Lamb博士在IU的领导下。 主要研究人员（MPIS）DRS。保罗·特里托（Paul Territo）和阿德里安·奥布拉克（Adrian Oblak）在IU博士。格雷格·卡特（Greg Carter），加雷斯·豪威尔（Gareth Howell）， 以及Jax的Mike Sasner，Pitt的Stacey Rizzo博士，Sage Bionetworks的Anna Greenwood博士和 在IU和JAX的计划共同经理和全职管理员的支持下，将监督所有 中心的行政和科学功能。管理员核心将通过 外部顾问委员会（EAB）的监督完成了该领域的领先专家和中心 指导委员会（CSC）符合IU/JAX/PITT和UCI Model-Ad Center PIS和NIH计划 官员。 EAB每年将方便地，每月CSC和整个Model-AD联盟每月 审查进度并提供输入和反馈（口头和书面），以确保中心（1）实现 它的使命，目标，里程碑和指标； （2）协调两个模型中心的努力； （3） 有效地处理任何意外的问题或问题； （4）适应可能的实验和 该领域的技术进步。将举行双周管理，BDMC，DMP和PTC会议和联合会议 BDMC/DMP会议。这些将集中在特定核心/项目所特有的问题上，同时确保 IU/JAX/PITT模型中心的各个组件之间的最大协同作用。关闭相互作用 将在BDMC，PTC和DMP中培养，从而促进及时发现 总体成本。管理员核心的主要目标之一将是确保发现的发现 该中心的区域将使中心整体受益，从而提高时间和成本的效率。最后，管理员 核心还将促进中心互动和与其他正在进行的研究工作的会议 阿尔茨海默氏症的研究界，包括NIA支持的ADRC，阿尔茨海默氏病 神经影像倡议（ADNI），阿尔茨海默氏病加速医学的伙伴关系（AMP-AD）， 以及可以加快阿尔茨海默氏病的治疗发展的目标（治疗AD） 财团。 IU/JAX/PITT Model-AD管理员核心的具体目的如下： 1。提供IU/JAX/PITT的有效管理，监督和评估 模型AD中心及其与广告研究界的互动。 2.确保及时完成所有项目以及核心目标和里程碑的完成。 3。促进生物信息学和数据管理核心之间的互动， 临床前测试核心和疾病模型项目。