Administrative and Coordination Core

项目摘要管理（管理）核心 印第安纳州大学（IU）/杰克逊实验室（JAX）管理中心（ADMIN）阿尔茨海默病 疾病精度模型中心（IU/JAX ADPMC），由IU的ADMIN负责人布鲁斯兰姆博士领导， 来自IU的多位主要研究者（mPI）Paul Terito博士和Greg Carter博士的协助， Gareth豪厄尔在JAX，沿着的支持下，两个博士级项目共同经理和全职 IU和JAX的管理员将监督中心的所有行政和科学职能。 ADMIN核心将在外部咨询委员会（EAB）的监督下执行这些职责， 由该领域的主要专家组成，以及由PI组成的中心指导委员会（CSC）， IU和JAX的研究领导者，以及NIH的项目官员。EAB将召集 每半年和CSC每月审查进展情况，并提供输入和反馈（口头和书面）， 确保IU/JAX ADPMC（1）实现其使命、目标、里程碑和指标;（2）有效地 处理任何意想不到的问题或关注;（3）适应可能的实验和技术 该领域的进展。将有每周的管理会议和每月的核心和项目会议。 这些将侧重于特定核心/项目特有的问题，同时确保最大的协同作用 在IU/JAX ADPMC的各个组件之间。将促进各组织之间的密切互动， 生物信息学和数据管理核心，临床前测试核心和疾病模型 开发和表型分析项目，从而加快发现速度，同时降低总体成本。 ADMIN核心的主要目标之一是确保在一个领域的发现， ADPMC将使整体受益，从而提高时间和成本效率。最后，ADMIN核心还将 促进IU/JAX ADPMC与其他正在进行的研究工作的互动和会议， 阿尔茨海默病研究社区，包括NIA支持的ADC/ADRC，阿尔茨海默病 神经影像学倡议（ADNI），阿尔茨海默病加速医学伙伴关系（AD-AMP），以及 阿尔茨海默病测序项目（ADSP） IU/JAX ADPMC ADMIN核心的具体目标是： 1.对IU/JAX ADPMC进行有效和高效的管理、监督和评价 以及与AD研究界的互动。 2.确保及时和成功地完成所有项目和核心目标和里程碑。 3.促进生物信息学和数据管理核心、 临床前测试核心和疾病模型开发和表型项目。 !

PROJECT SUMMARY ADMINISTRATIVE (ADMIN) CORE The Administration (ADMIN) Core of the Indiana University (IU)/Jackson Laboratory (JAX) Alzheimer's Disease Precision Models Center (IU/JAX ADPMC), led by ADMIN Head Dr. Bruce Lamb at IU and with assistance from multiple Principle Investigators (mPIs) Dr. Paul Territo at IU and Drs. Greg Carter and Gareth Howell at JAX, along with the support of two PhD-level Program co-Managers and full-time administrators at both IU and JAX, will oversee all administrative and scientific functions of the Center. The ADMIN Core will execute these duties with oversight from an External Advisory Board (EAB), composed of leading experts in the field, and a Center Steering Committee (CSC), composed of the PIs, research leaders at both IU and JAX, and program officials from the NIH. The EAB will convene biannually and the CSC monthly to review progress and provide input and feedback (oral and written) to ensure that the IU/JAX ADPMC (1) achieves its mission, aims, milestones and metrics; (2) effectively deals with any unanticipated problems or concerns; and (3) adapts to likely experimental and technical advances in the field. There will be weekly ADMIN meetings and monthly Core and Project meetings. These will be focused on issues unique to specific Cores/Project while ensuring maximal synergy between the various components of the IU/JAX ADPMC. Close interaction will be fostered among the Bioinformatics and Data Management Core, the Preclinical Testing Core and the Disease Model Development and Phenotyping Project, thus facilitating the speed of discovery while reducing overall cost. One of the primary goals of the ADMIN Core will be to ensure that discoveries made in one area of the ADPMC will benefit the whole, leading to efficiencies in time and cost. Finally, the ADMIN Core will also promote interactions and meetings of the IU/JAX ADPMC with other ongoing research efforts in the Alzheimer's research community, including the NIA-supported ADCs/ADRCs, the Alzheimer's Disease Neuroimaging Initiative (ADNI), Alzheimer's Disease Accelerating Medicine's Partnership (AD-AMP), and the Alzheimer's Disease Sequencing Project (ADSP). The Specific Aims of the IU/JAX ADPMC ADMIN Core are: 1. Provide effective and efficient management, oversight and evaluation of the IU/JAX ADPMC and interactions with the AD research community. 2. Ensure timely and successful completion of all project and core aims and milestones. 3. Facilitate interactions between and among the Bioinformatics and Data Management Core, the Preclinical Testing Core and the Disease Model Development and Phenotyping Project. !