Core B. Biostatistics, Bioinformatics and Genetic Analysis (BBGA)

核心 B. 生物统计学、生物信息学和遗传分析 (BBGA)

• 批准号: 10707329
• 负责人: Xiaoyi Raymond Gao
• 金额: $ 14.3万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10707329
• 关键词: Applications Grants; Arts; Bioinformatics; Biological; Biometry; Blindness; Clinic; Clinical Investigator; Clinical Research; Collaborations; Communities; Computer software; Computers; Consultations; Copy Number Polymorphism; Data; Data Analyses; Data Science; Databases; Detection; Documentation; Engineering; Ensure; Environment; Equilibrium; Equipment; Exclusion; Eye; Eye diseases; Faculty; Funding; Future; Gender Identity; Gene Frequency; Genes; Genetic; Genetic Research; Genetic study; Genomics; Goals; Group Meetings; High Performance Computing; Individual; Institution; Jordan; Leadership; Letters; Manuscripts; Medicine; Methodology; Minor; Molecular Biology; Neurosciences; Ohio; Ophthalmology; Optometry; Outcome; Pathway Analysis; Pediatric Hospitals; Pediatrics; Preparation; Proteomics; Protocols documentation; Psychology; Quality Control; Regression Analysis; Research; Research Design; Research Personnel; Research Project Grants; Resources; Sample Size; Sampling; Science; Science of genetics; Scientist; Services; Single Nucleotide Polymorphism; Statistical Data Interpretation; Surveys; Testing; Training; Universities; Veterinary Medicine; Vision; Vision research; Work; advanced analytics; clinical translation; cluster computing; college; cost; data management; design; equipment acquisition; exome; gene environment interaction; genetic analysis; genetic association; genome sequencing; high standard; meetings; population stratification; prevent; programs; sight restoration; single-cell RNA sequencing; skills; statistics; supercomputer; synergism; transcriptome sequencing; transcriptomics; treatment response; variant detection; vision science; whole genome

Abstract: CORE B. BIOSTATISTICS, BIOINFORMATICS AND GENETIC ANALYSIS (BBGA) The Ohio State University Vision Sciences Research Core Program (OSU-VSRCP) has established scientific connections among the vision researchers across five academic units (i.e., College of Medicine (COM), College of Optometry (COO), College of Engineering, College of Veterinary Medicine, College of Arts and Sciences) and newly engaged Nationwide Children’s Hospital. Program Director (PD) Dr. Moroi has support and commitment from Deans and Chairs for equipment, data science, space, new and existing programs to enhance collaborations among NEI-funded PIs, facilitate gathering pilot data for future PIs, and subsidizes cost for access to the High-Performance Computing Cluster (HPCC) that is maintained by the Ohio Supercomputer Center (OSC), which is relevant for Core B. The synergy among the vision research community has been established with a monthly meeting group called ViSOR (Vision Sciences OSU Research). Synergy between the Cores has been defined with a Steering Committee, which is composed of the PD, Core Directors and Co- directors. This synergy between Cores will coincide with the monthly ViSOR meetings, and ad hoc as needed for operational issues and future equipment purchases. In addition, an Advisory Group has been established to give guidance to the Steering Committee. Core B, BBGA Core has two aims: Aim 1. Provide analytical assistance for analyses of vision research data. The BBGA Core will provide analytical expertise for research data arising from clinic-based and genetic studies, such as whole-exome sequence, whole-genome sequencing, bulk RNA-Seq, and scRNA-Seq projects. The biostatistics staff will work with investigators of clinical research projects to design well-powered studies; assist in data management; and provide rigorous statistical analysis, including the appropriate methodology to deal with the intricacies of the correlation of two eyes. Aim 2. Provide consultation, training, and access to specialized software for genetic analyses of vision research data. The BBGA Core Director and staff will provide tailored consultations to users for planning and conducting their genetics research and analyses. Best practices will be promoted for study design, sample size estimation, and power calculation for bioinformatic and genetic components of grant applications. Training in the use of and access to specialized software for genetics and genomics analyses will be available. The added values are access to skilled experts in vision science genetics, the latest computation facilities, and specialized software for genetic analysis. This proposed P30 Core B, BBGA intends to maximize efficiency, offer centralized access to equipment and expertise that would be difficult, costly or impractical to duplicate in individual labs, and use protocols to ensure best practices to perform science at the highest standard. The expected outcome is increased collaboration for successful new proposals with the shared overarching goal to prevent blindness, restore vision and develop cures for eye diseases.

摘要：核心 B. 生物统计学、生物信息学和遗传分析 (BBGA) 俄亥俄州立大学视觉科学研究核心计划 (OSU-VSRCP) 建立了科学 五个学术单位（即医学院（COM）、 视光学院（COO）、工程学院、兽医学院、艺术学院 科学）和新近参与的全国儿童医院。项目总监 (PD) Moroi 博士提供支持 以及院长和主席对设备、数据科学、空间、新项目和现有项目的承诺 加强 NEI 资助的 PI 之间的合作，促进为未来的 PI 收集试点数据，并补贴成本 用于访问由俄亥俄州超级计算机维护的高性能计算集群 (HPCC) 中心（OSC），与核心 B 相关。视觉研究界之间的协同作用 与名为 ViSOR（俄勒冈州立大学视觉科学研究）的月度会议小组建立。之间的协同作用 指导委员会定义了核心，该委员会由 PD、核心董事和联合成员组成 董事。核心之间的这种协同作用将与每月 ViSOR 会议同时进行，并根据需要临时召开 用于运营问题和未来设备采购。此外，还成立了一个咨询小组 向指导委员会提供指导。核心 B，BBGA 核心有两个目标： 目标 1. 提供分析 协助分析视觉研究数据。 BBGA 核心将为以下人员提供分析专业知识： 来自临床和遗传学研究的研究数据，例如全外显子组序列、全基因组 测序、批量 RNA-Seq 和 scRNA-Seq 项目。生物统计人员将与研究人员合作 设计强有力的研究的临床研究项目；协助数据管理；并提供严格的 统计分析，包括处理两个数据之间复杂的相关性的适当方法 眼睛。目标 2. 提供咨询、培训和使用用于遗传分析的专用软件 视觉研究数据。 BBGA核心总监及工作人员将为用户提供量身定制的咨询 规划并进行遗传学研究和分析。将推广最佳实践以供研究 资助的生物信息和遗传成分的设计、样本量估计和功效计算 应用程序。遗传学和基因组学分析专用软件的使用和获取培训将 可用。附加值是接触视觉科学遗传学、最新计算方面的熟练专家 设施和遗传分析专用软件。这次提出的P30 Core B，BBGA打算最大化 效率，提供对设备和专业知识的集中访问，而这对于其他人来说是困难的、昂贵的或不切实际的 在各个实验室中进行复制，并使用协议来确保最佳实践以最高水平进行科学研究 标准。预期成果是加强与共享者的合作，以成功提出新提案。 总体目标是预防失明、恢复视力和开发眼科疾病的治疗方法。