Core B. Biostatistics, Bioinformatics and Genetic Analysis (BBGA)

核心 B. 生物统计学、生物信息学和遗传分析 (BBGA)

• 批准号: 10707329
• 负责人: Xiaoyi Raymond Gao
• 金额: $ 14.3万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10707329
• 关键词: Applications Grants; Arts; Bioinformatics; Biological; Biometry; Blindness; Clinic; Clinical Investigator; Clinical Research; Collaborations; Communities; Computer software; Computers; Consultations; Copy Number Polymorphism; Data; Data Analyses; Data Science; Databases; Detection; Documentation; Engineering; Ensure; Environment; Equilibrium; Equipment; Exclusion; Eye; Eye diseases; Faculty; Funding; Future; Gender Identity; Gene Frequency; Genes; Genetic; Genetic Research; Genetic study; Genomics; Goals; Group Meetings; High Performance Computing; Individual; Institution; Jordan; Leadership; Letters; Manuscripts; Medicine; Methodology; Minor; Molecular Biology; Neurosciences; Ohio; Ophthalmology; Optometry; Outcome; Pathway Analysis; Pediatric Hospitals; Pediatrics; Preparation; Proteomics; Protocols documentation; Psychology; Quality Control; Regression Analysis; Research; Research Design; Research Personnel; Research Project Grants; Resources; Sample Size; Sampling; Science; Science of genetics; Scientist; Services; Single Nucleotide Polymorphism; Statistical Data Interpretation; Surveys; Testing; Training; Universities; Veterinary Medicine; Vision; Vision research; Work; advanced analytics; clinical translation; cluster computing; college; cost; data management; design; equipment acquisition; exome; gene environment interaction; genetic analysis; genetic association; genome sequencing; high standard; meetings; population stratification; prevent; programs; sight restoration; single-cell RNA sequencing; skills; statistics; supercomputer; synergism; transcriptome sequencing; transcriptomics; treatment response; variant detection; vision science; whole genome

Abstract: CORE B. BIOSTATISTICS, BIOINFORMATICS AND GENETIC ANALYSIS (BBGA) The Ohio State University Vision Sciences Research Core Program (OSU-VSRCP) has established scientific connections among the vision researchers across five academic units (i.e., College of Medicine (COM), College of Optometry (COO), College of Engineering, College of Veterinary Medicine, College of Arts and Sciences) and newly engaged Nationwide Children’s Hospital. Program Director (PD) Dr. Moroi has support and commitment from Deans and Chairs for equipment, data science, space, new and existing programs to enhance collaborations among NEI-funded PIs, facilitate gathering pilot data for future PIs, and subsidizes cost for access to the High-Performance Computing Cluster (HPCC) that is maintained by the Ohio Supercomputer Center (OSC), which is relevant for Core B. The synergy among the vision research community has been established with a monthly meeting group called ViSOR (Vision Sciences OSU Research). Synergy between the Cores has been defined with a Steering Committee, which is composed of the PD, Core Directors and Co- directors. This synergy between Cores will coincide with the monthly ViSOR meetings, and ad hoc as needed for operational issues and future equipment purchases. In addition, an Advisory Group has been established to give guidance to the Steering Committee. Core B, BBGA Core has two aims: Aim 1. Provide analytical assistance for analyses of vision research data. The BBGA Core will provide analytical expertise for research data arising from clinic-based and genetic studies, such as whole-exome sequence, whole-genome sequencing, bulk RNA-Seq, and scRNA-Seq projects. The biostatistics staff will work with investigators of clinical research projects to design well-powered studies; assist in data management; and provide rigorous statistical analysis, including the appropriate methodology to deal with the intricacies of the correlation of two eyes. Aim 2. Provide consultation, training, and access to specialized software for genetic analyses of vision research data. The BBGA Core Director and staff will provide tailored consultations to users for planning and conducting their genetics research and analyses. Best practices will be promoted for study design, sample size estimation, and power calculation for bioinformatic and genetic components of grant applications. Training in the use of and access to specialized software for genetics and genomics analyses will be available. The added values are access to skilled experts in vision science genetics, the latest computation facilities, and specialized software for genetic analysis. This proposed P30 Core B, BBGA intends to maximize efficiency, offer centralized access to equipment and expertise that would be difficult, costly or impractical to duplicate in individual labs, and use protocols to ensure best practices to perform science at the highest standard. The expected outcome is increased collaboration for successful new proposals with the shared overarching goal to prevent blindness, restore vision and develop cures for eye diseases.

摘要：CORE B。生物统计学、生物信息学和遗传分析（BBGA） 俄亥俄州州立大学视觉科学研究核心计划（OSU-VSRCP）已经建立了科学的 五个学术单位的视觉研究人员之间的联系（即，医学院（COM）， 视光学学院（COO）、工程学院、兽医学院、艺术学院和 新成立的全国儿童医院。项目总监（PD）Moroi博士支持 以及院长和主席对设备、数据科学、空间、新的和现有的项目的承诺， 加强NEI资助的PI之间的合作，促进为未来PI收集试验数据，并补贴费用 访问由俄亥俄州超级计算机维护的高性能计算集群（HPCC 中心（OSC），与核心B相关。视觉研究界之间的协同作用已经 成立了一个名为ViSOR（视觉科学OSU研究）的月度会议小组。之间的协同作用 核心小组由一个指导委员会确定，该委员会由PD、核心主任和联合主任组成， 董事们。核心之间的这种协同作用将与每月的ViSOR会议同时进行，并根据需要进行特别安排 用于操作问题和未来的设备采购。此外，还设立了一个咨询小组， 指导指导委员会。核心B，BBGA核心有两个目标：目标1。提供分析 协助分析视觉研究数据。BBGA核心将提供分析专业知识， 来自临床和遗传研究的研究数据，如全外显子组序列、全基因组序列 测序、批量RNA-Seq和scRNA-Seq项目。生物统计人员将与以下研究者合作： 临床研究项目，以设计有力的研究;协助数据管理;并提供严格的 统计分析，包括适当的方法来处理两个相互关系的复杂性， 眼睛目标2.提供咨询、培训和使用专门软件进行遗传分析， 视觉研究数据。BBGA核心总监和工作人员将为用户提供量身定制的咨询， 规划和开展遗传学研究和分析。将推广最佳做法供研究 生物信息学和遗传学成分的设计、样本量估计和功效计算 应用.关于使用和获取遗传学和基因组学分析专用软件的培训将 随时待命附加值是获得视觉科学遗传学，最新的计算技术， 设施和专门的遗传分析软件。BBGA提出的P30核心B旨在最大限度地 效率，提供集中的设备和专业知识，这将是困难的，昂贵的或不切实际的， 在各个实验室重复，并使用协议，以确保最佳实践，以最高水平执行科学 标准预期的结果是加强合作，以成功地提出新的建议， 其总体目标是预防失明、恢复视力和开发治疗眼疾的方法。