Administrative Core

行政核心（核心A） 由Jeffrey Myers博士和Vlad Sandulache博士领导并由中心支持的行政核心 管理员Toyin Babarinde博士是休斯顿获得性耐药中心不可或缺的组成部分 研究（H-CARR）。行政核心（核心A）的总体目标是提供关键的集中管理， 支持H-CARR，确保三个项目和核心之间的无缝交互和集成 在中心内以及更广泛的ARTNet社区。核心A旨在监测研究活动， 提供稳定和持续的领导，指导该研究中心未来的科学方向。核心 A将利用中心咨询小组在关键领域的广泛科学研究相关经验， 决策步骤。行政核心将确保强调基本的机械和翻译 研究和促进跨学科和项目间的整合，包括协助建立 与其他ARTNet中心以及U24 ARTNet协调数据和管理中心的合作 （ARTNet CDMC U24）和NCI工作人员。核心A还将全面负责财政和预算 H-CARR的管理，包括雇用关键人员，以确保高素质的，良好的 经过培训、管理和多样化的劳动力队伍，使资源的使用具有成本效益和效率。这 核心还将监测科学的完整性和所有机构，州，联邦和NCI的总体遵守情况 法规和要求，以及数据完整性的质量保证。核心A的力量在于 一个由项目内、机构内和外部顾问组成的完善结构，他们都致力于 通过持续的审查、建议、定期会议和建议来支持核心A领导者，以确保 强劲的科学业绩和朝着商定的计划目标取得的进展。的指导下 核心A领导者，核心A还将为研究提供支持和基础设施， 所有H-CARR研究者之间的通信，为监管监测提供集中资源， 合规活动，并定期审查项目和核心活动及其进展情况， 目标.在核心A领导人的指导下，核心A还将为研究提供支持和基础设施， 促进所有H-CARR研究者之间的清晰和公开的沟通，参与监管监测， 优化耐药的基本机制和临床前/转化研究的成功结果， 头颈癌的药物治疗

Administrative Core (Core A) SUMMARY The Administrative Core, led by Dr. Jeffrey Myers and Dr. Vlad Sandulache, and supported by the Center Administrator Dr. Toyin Babarinde, is an indispensable component of the Houston Center for Acquired Resistance Research (H-CARR). The overall objective of the Administrative Core (Core A) is to provide critical centralized support to the H-CARR and ensure seamless interactions and integration between the three projects and cores within the center as well as the broader ARTNet community. Core A is designed to monitor research activity and provide stable and continuous leadership that guides future scientific directions for this Research Center. Core A will leverage the wide-ranging scientific, research related experience of the Center Advisory Group in critical decision-making steps. The Administrative Core will ensure an emphasis on basic mechanistic and translational research and facilitate interdisciplinary and inter-project integration, including assistance in the establishment of collaborations with other ARTNet centers as well as the U24 ARTNet Coordinating Data and Management Center (ARTNet CDMC U24) and NCI staff. Core A will also have overall responsibility for fiscal and budgetary management of the H-CARR, including the employment of key personnel to ensure a highly qualified, well trained, managed, and diverse work force that will enable cost-effective and efficient use of resources. This Core will also monitor scientific integrity and overall compliance with all institutional, state, federal, and NCI regulations and requirements, as well as quality assurance for data integrity. The strength of Core A rest in its well-developed structure of intra-programmatic, intra-institutional, and external advisors who are all dedicated to support Core A Leaders through ongoing review, advice, and periodic meetings and recommendations to ensure robust scientific performance and progress toward the agreed upon programmatic goals. Under the direction of the Core A Leaders, Core A will also provide support and infrastructure for research, facilitate clear and open communications among all H-CARR investigators, provide a centralized resource for regulatory monitoring and compliance activities, and perform scheduled reviews of project and core activities and progress towards their goals. Under the direction of the Core A Leaders, Core A will also provide support and infrastructure for research, facilitate clear and open communications among all H-CARR investigators, engage in regulatory monitoring to optimize the successful outcome of the basic mechanistic and preclinical/translational research in resistance to drug therapy in head and neck cancer.