ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale Modeling
ChimeraX——用于多尺度建模的下一代可视化和分析软件
基本信息
- 批准号:10707058
- 负责人:
- 金额:$ 66.47万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-07-01 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAbateAddressAdvanced DevelopmentAlgorithmsAmino Acid SequenceAreaAttentionBase SequenceBiologicalBiological ProcessBiomedical ResearchBrainCell physiologyCellsCellular StructuresChargeCommunitiesComplexComputational BiologyComputer GraphicsComputer softwareComputersCryoelectron MicroscopyDataData AnalysesData SetDevelopmentDiseaseDockingDocumentationDrosophila genusDrug DesignDrug TargetingEducational process of instructingElectron MicroscopyElementsFaceFeedbackFoundationsFundingGoalsGrowthImageIntuitionJournalsKnowledgeLengthLifeLightingLinkMapsMethodsMicroscopyModelingMolecularMolecular AnalysisMolecular ConformationMolecular MachinesMolecular StructureMutationOperating SystemOutcomePatternPerformanceProcessProductionPropertyProtein EngineeringProteinsPublicationsReadingReportingResearchResearch PersonnelResearch Project GrantsResolutionRoleScientistSequence AlignmentSoftware EngineeringSoftware ToolsSource CodeStructureTalentsTechniquesThree-dimensional analysisTimeTissue imagingTissuesTomogramTrainingUnited States National Institutes of HealthVisualizationVisualization softwareWorkanimationapplied biomedical researchbasebiological systemscomplex datadensitydesigndrug developmentexperimental studyflexibilityhuman diseaseinnovationinsightinteractive toollecturesmachine learning methodmolecular assembly/self assemblymolecular dynamicsmouse modelmoviemulti-scale modelingmultidimensional datanext generationparticleprecision medicinesoftware repositorystatisticsstructural biologytechnology developmentthree-dimensional visualizationtimelinetomographytoolvirtual realityweb based softwareweb site
项目摘要
PROJECT SUMMARY/ABSTRACT
The goal of this project is to enable scientific discovery and advances in biomedical research through
the development of cutting-edge software tools that provide integrated visualizations and analyses of
molecular structures and related biological information. Our tools can be applied to diverse types of
biomolecular data, including atomic-resolution coordinates, 3D cryo-EM density maps, and protein
and nucleic acid sequences, annotations, and networks. We focus on unmet software needs for basic
and applied biomedical research using highly trained and talented staff, with excellent interdisciplinary
knowledge and specialized, state-of-the-art expertise in software engineering, computer graphics
visualization, and data analysis. Our primary efforts are in the interactive visualization and analysis of
structures of molecules, molecular assemblies, and protein sequence-structure relationships. These
areas are critical for addressing important and highly relevant biomedical problems such as
identifying the molecular bases of disease, identifying targets for drug development, designing drugs,
and engineering proteins with new functions. Our software tools enable scientists to understand,
analyze, and illustrate to others the important principles of molecular structure, function, and
interactions. These tools are widely recognized as works of the highest quality, and are available for
free on our website in binary and source-code form. We support and maintain these tools, and
provide detailed documentation and tutorials. Our technological developments are disseminated
widely via scientific publications, lectures, software distribution, and video animations.
项目总结/文摘
项目成果
期刊论文数量(190)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
FtsEX-independent control of RipA-mediated cell separation in Corynebacteriales.
- DOI:10.1073/pnas.2214599119
- 发表时间:2022-12-13
- 期刊:
- 影响因子:11.1
- 作者:Gaday, Quentin;Megrian, Daniela;Carloni, Giacomo;Martinez, Mariano;Sokolova, Bohdana;Ben Assaya, Mathilde;Legrand, Pierre;Brule, Sebastien;Haouz, Ahmed;Wehenkel, Anne Marie;Alzari, Pedro M.
- 通讯作者:Alzari, Pedro M.
Structural Studies Reveal that Endosomal Cations Promote Formation of Infectious Coxsackievirus A9 A-Particles, Facilitating RNA and VP4 Release.
- DOI:10.1128/jvi.01367-22
- 发表时间:2022-12-21
- 期刊:
- 影响因子:5.4
- 作者:
- 通讯作者:
Structural insights into the Venus flytrap mechanosensitive ion channel Flycatcher1.
- DOI:10.1038/s41467-022-28511-5
- 发表时间:2022-02-14
- 期刊:
- 影响因子:16.6
- 作者:Jojoa-Cruz S;Saotome K;Tsui CCA;Lee WH;Sansom MSP;Murthy SE;Patapoutian A;Ward AB
- 通讯作者:Ward AB
Identification of a carbonic anhydrase-Rubisco complex within the alpha-carboxysome.
- DOI:10.1073/pnas.2308600120
- 发表时间:2023-10-24
- 期刊:
- 影响因子:11.1
- 作者:Blikstad, Cecilia;Dugan, Eli J.;Laughlin, Thomas G.;Turnsek, Julia B.;Liu, Mira D.;Shoemaker, Sophie R.;Vogiatzi, Nikoleta;Remis, Jonathan P.;Savage, David F.
- 通讯作者:Savage, David F.
Alignment of major-groove hydrogen bond arrays uncovers shared information between different DNA sequences that bind the same protein.
- DOI:10.1093/nargab/lqac101
- 发表时间:2022-12
- 期刊:
- 影响因子:4.6
- 作者:Sedhom, Jacklin;Kinser, Jason;Solomon, Lee A.
- 通讯作者:Solomon, Lee A.
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{{ truncateString('THOMAS E FERRIN', 18)}}的其他基金
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale Modeling
ChimeraX——用于多尺度建模的下一代可视化和分析软件
- 批准号:
10442109 - 财政年份:2018
- 资助金额:
$ 66.47万 - 项目类别:
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale Modeling
ChimeraX——用于多尺度建模的下一代可视化和分析软件
- 批准号:
9973164 - 财政年份:2018
- 资助金额:
$ 66.47万 - 项目类别:
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale Modeling
ChimeraX——用于多尺度建模的下一代可视化和分析软件
- 批准号:
10192752 - 财政年份:2018
- 资助金额:
$ 66.47万 - 项目类别:
ENHANCE CHIMERA'S ANIMATION AND PHYSICAL MODELING CAPABILITIES
增强 Chimera 的动画和物理建模能力
- 批准号:
8363632 - 财政年份:2011
- 资助金额:
$ 66.47万 - 项目类别:
INTERNATIONAL GENE TRAP CONSORTIUM (IGTC) RESOURCE
国际基因陷阱联盟 (IGTC) 资源
- 批准号:
8363603 - 财政年份:2011
- 资助金额:
$ 66.47万 - 项目类别:
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