ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale Modeling

ChimeraX——用于多尺度建模的下一代可视化和分析软件

基本信息

项目摘要

PROJECT SUMMARY/ABSTRACT The goal of this project is to enable scientific discovery and advances in biomedical research through the development of cutting-edge software tools that provide integrated visualizations and analyses of molecular structures and related biological information. Our tools can be applied to diverse types of biomolecular data, including atomic-resolution coordinates, 3D cryo-EM density maps, and protein and nucleic acid sequences, annotations, and networks. We focus on unmet software needs for basic and applied biomedical research using highly trained and talented staff, with excellent interdisciplinary knowledge and specialized, state-of-the-art expertise in software engineering, computer graphics visualization, and data analysis. Our primary efforts are in the interactive visualization and analysis of structures of molecules, molecular assemblies, and protein sequence-structure relationships. These areas are critical for addressing important and highly relevant biomedical problems such as identifying the molecular bases of disease, identifying targets for drug development, designing drugs, and engineering proteins with new functions. Our software tools enable scientists to understand, analyze, and illustrate to others the important principles of molecular structure, function, and interactions. These tools are widely recognized as works of the highest quality, and are available for free on our website in binary and source-code form. We support and maintain these tools, and provide detailed documentation and tutorials. Our technological developments are disseminated widely via scientific publications, lectures, software distribution, and video animations.
项目总结/文摘

项目成果

期刊论文数量(190)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
FtsEX-independent control of RipA-mediated cell separation in Corynebacteriales.
Structural insights into the Venus flytrap mechanosensitive ion channel Flycatcher1.
  • DOI:
    10.1038/s41467-022-28511-5
  • 发表时间:
    2022-02-14
  • 期刊:
  • 影响因子:
    16.6
  • 作者:
    Jojoa-Cruz S;Saotome K;Tsui CCA;Lee WH;Sansom MSP;Murthy SE;Patapoutian A;Ward AB
  • 通讯作者:
    Ward AB
Identification of a carbonic anhydrase-Rubisco complex within the alpha-carboxysome.
Alignment of major-groove hydrogen bond arrays uncovers shared information between different DNA sequences that bind the same protein.
  • DOI:
    10.1093/nargab/lqac101
  • 发表时间:
    2022-12
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Sedhom, Jacklin;Kinser, Jason;Solomon, Lee A.
  • 通讯作者:
    Solomon, Lee A.
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THOMAS E FERRIN其他文献

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{{ truncateString('THOMAS E FERRIN', 18)}}的其他基金

ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale Modeling
ChimeraX——用于多尺度建模的下一代可视化和分析软件
  • 批准号:
    10442109
  • 财政年份:
    2018
  • 资助金额:
    $ 66.47万
  • 项目类别:
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale Modeling
ChimeraX——用于多尺度建模的下一代可视化和分析软件
  • 批准号:
    9973164
  • 财政年份:
    2018
  • 资助金额:
    $ 66.47万
  • 项目类别:
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale Modeling
ChimeraX——用于多尺度建模的下一代可视化和分析软件
  • 批准号:
    10192752
  • 财政年份:
    2018
  • 资助金额:
    $ 66.47万
  • 项目类别:
RBVI OUTREACH AND TRAINING
RBVI 外展和培训
  • 批准号:
    8363626
  • 财政年份:
    2011
  • 资助金额:
    $ 66.47万
  • 项目类别:
CHIMERA WEB SERVICES EXTENSIONS
Chimera 网络服务扩展
  • 批准号:
    8363630
  • 财政年份:
    2011
  • 资助金额:
    $ 66.47万
  • 项目类别:
SEQUENCE ANALYSIS SOFTWARE DEVELOPMENT
序列分析软件开发
  • 批准号:
    8363585
  • 财政年份:
    2011
  • 资助金额:
    $ 66.47万
  • 项目类别:
CHIMERA EXTENSIONS FOR IMP
IMP 的嵌合体延伸
  • 批准号:
    8363631
  • 财政年份:
    2011
  • 资助金额:
    $ 66.47万
  • 项目类别:
ENHANCE CHIMERA'S ANIMATION AND PHYSICAL MODELING CAPABILITIES
增强 Chimera 的动画和物理建模能力
  • 批准号:
    8363632
  • 财政年份:
    2011
  • 资助金额:
    $ 66.47万
  • 项目类别:
UPDATING THE RBVI ANNUAL REPORT SYSTEM
更新 RBVI 年度报告系统
  • 批准号:
    8363600
  • 财政年份:
    2011
  • 资助金额:
    $ 66.47万
  • 项目类别:
INTERNATIONAL GENE TRAP CONSORTIUM (IGTC) RESOURCE
国际基因陷阱联盟 (IGTC) 资源
  • 批准号:
    8363603
  • 财政年份:
    2011
  • 资助金额:
    $ 66.47万
  • 项目类别:

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