RBVI OUTREACH AND TRAINING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 生物计算、可视化和信息学资源(RBVI)为计算和基于可视化的数据分析开发了创新的方法和算法，将其作为专业质量的、易于使用的软件工具来实现，并将这些工具应用于解决与分子序列、结构和功能相关的广泛问题。 UCSF Chimera(www.cgl.ucsf.edu/chiera)是RBVI正在积极开发的分子建模软件包。嵌合体是一种可视化和分析生物分子结构和相互作用的工具。除了原子坐标，它还可用于探索其他数据类型，如电子密度图、静电势图和序列比对，并可用于创建高质量的图像和电影以供发布和演示。 为了探索更广泛的生物学背景，RBVI还开发并分发插件到开源网络可视化工具Cytoscape。蛋白质序列或结构相似性网络、代谢途径和小分子代谢物或药物网络是感兴趣的系统的几个例子。这些插件提供了操纵和分析网络并使用Chimera将其链接到3D可视化的功能。 结构-功能连锁数据库(sfld.rbvi.ucsf.edu)将进化上相关的序列和结构(酶的超家族)与它们的化学反应联系起来，并将保守的活性位点残基与超家族成员共同的特定部分反应联系起来。它提供了关于机械多样化的超家族的高度精选的信息，这些超家族催化了许多不同的整体反应，并在历史上受到许多注释问题的影响。这一公共资源可用于指导功能注释和蛋白质工程应用。 序列分析和咨询服务(SACS，www.sas.ucsf.edu)提供生物信息学、分子可视化和分析以及网络可视化和分析方面的专业知识。它还提供对序列分析软件和序列数据库的最新版本的本地访问。 随着发展的继续，RBVI团队必须通过外联和培训与更广泛的结构和分子生物学研究和教学界保持联系。这些活动提高了人们对资源可以提供什么的认识，从而更有效地利用资源并推动进一步的发展。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Resource for Biocomputing, Visualization and Informatics (RBVI) develops innovative methods and algorithms for computational and visualization-based data analysis, implements these as professional-quality, easy-to-use software tools, and applies the tools toward solving a wide range of problems relating to molecular sequence, structure, and function. UCSF Chimera (www.cgl.ucsf.edu/chimera) is the molecular modeling package under active development by the RBVI. Chimera is a tool for visualization and analysis of biomolecular structures and interactions. In addition to atomic coordinates, it can be used to explore other data types such as electron density maps, electrostatic potential maps, and sequence alignments, and it can be used to create high-quality images and movies for publication and presentation. For exploring broader biological contexts, RBVI also develops and distributes plugins to the open-source network visualization tool Cytoscape. Protein sequence or structure similarity networks, metabolic pathways, and networks of small molecule metabolites or drugs are a few examples of systems of interest. The plugins provide capabilities for manipulating and analyzing the networks and linking them to 3D visualization with Chimera. The Structure-Function Linkage Database (sfld.rbvi.ucsf.edu) connects evolutionarily related sequences and structures (superfamilies of enzymes) to their chemical reactions, and correlates conserved active site residues with specific partial reactions common to the members of a superfamily. It provides highly curated information on mechanistically diverse superfamilies, which catalyze many different overall reactions and have historically been subject to many annotation problems. This public resource can be used to guide functional annotation and protein engineering applications. The Sequence Analysis and Consulting Service (SACS, www.sacs.ucsf.edu) provides expertise in bioinformatics, molecular visualization and analysis, and network visualization and analysis. It also provides local access to up-to-date versions of sequence analysis software and sequence databases. As development continues, it is imperative that the RBVI team remains connected to the broader structural and molecular biology research and teaching community through outreach and training. These activities promote awareness of what the Resource has to offer, resulting in more effective use and driving further developments.