Southeastern Predoctl Training in Clinical Research(RMI)

东南临床研究博士前培训（RMI）

• 批准号: 7664567
• 负责人: THOMAS C HULSEY
• 金额: --
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-20 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7664567
• 关键词: Clinical Research; Training

he Southeastern Predoctoral Training Program is designed to increase the number of well-trained clinical researchers who will assume leadership roles in the design, conduct and oversight of future clinical investigations. Our hypothesis is that we can train individuals to become rigorous, high quality and proactive clinical investigators by teaching the principles and practice of clinical investigation and the application of cutting edge technology to clinical research. To test this hypothesis we will conduct the following specific aims: 1) For predoctoral students from College of Medicine, College of Dental Medicine, College of Nursing, College of Pharmacy, College of Graduate Studies, and College of Health Professions, provide clinical research training including development of basic skills in biostatistics, epidemiology, clinical trials, health services research, measurement, recruitment and retention of diverse populations in clinical research; and in the application of cutting edge research technologies; 1.a Offer a carefully designed yet flexible curriculum that enables students to ultimately function independently in clinical investigation, 1 b. Conduct the training in a challenging, interactive environment that involves students, faculty members and mentors structured around an initial one week orientation, an intensive summer session, a one year "pull-out" for an MS degree, or a PhD in clinical investigation via the Medical Scientist Training Program or Dental Scientist Training Program. Training activities include in addition to the didactic courses, rotations in the different domains of clinical research, a monthly science seminar series and journal club, visits by role models, and presentation of their research at the MUSC Student Research Day, 2) Increase the number of well-trained clinical researchers who will, in the future, assume leadership roles in the design, conduct, and oversight of multi- disciplinary, collaborative clinical investigations critical to the mission of NIH and 2a. Train individuals to assemble and lead the appropriate multidisciplinary teams needed to carry out their clinical research. In addition to the core curriculum, we are educating the trainees in the following areas of cutting edge technology; proteomics, genetics, DNA microarrays, viral vectors, 64 slice CT scanning, functional MRI, regenerative medicine and zebra fish technology. With these approaches we will train the next generation of rigorous, futuristic thinking clinical investigators who will be able to contribute to improving the health of the nation.

东南部博士前培训计划旨在增加训练有素的临床医生的数量。 将在未来临床研究的设计、实施和监督中发挥领导作用的研究人员 调查事务所我们的假设是，我们可以训练个人变得严谨，高品质和积极主动 临床研究者通过教学的原则和实践的临床研究和应用 尖端技术应用于临床研究为了验证这一假设，我们将进行以下具体的 目的：1）为医学院，牙科医学院，护理学院， 药学院、研究生院和健康护理学院提供临床 研究培训，包括发展生物统计学、流行病学、临床试验、健康 服务研究，测量，招募和保留临床研究中的不同人群;以及 尖端研究技术的应用; 1.a提供精心设计但灵活的课程 使学生最终能够在临床研究中独立发挥作用，1 B。进行培训， 一个具有挑战性的，互动的环境，涉及学生，教师和导师结构 围绕最初的一周方向，一个密集的夏季会议，一年的"退出"的MS学位， 或通过医学科学家培训计划或牙科科学家培训获得临床研究博士学位 程序.除了教学课程外，培训活动还包括在不同领域的轮换， 临床研究，每月一次的科学研讨会系列和期刊俱乐部，榜样的访问，以及演讲 他们的研究在MUSC学生研究日，2）增加训练有素的临床 研究人员谁将，在未来，承担领导作用的设计，行为，和监督的多， 学科，合作临床研究的关键使命的NIH和2a。培训个人， 组建并领导开展临床研究所需的适当的多学科团队。在 除了核心课程外，我们还在以下前沿领域教育学员 技术;蛋白质组学，遗传学，DNA微阵列，病毒载体，64层CT扫描，功能性MRI， 再生医学和斑马鱼技术。通过这些方法，我们将培养下一代 严谨，未来思维的临床研究人员谁将能够有助于改善健康的 民族

项目成果

Oxidative stress sensitizes bladder cancer cells to TRAIL mediated apoptosis by down-regulating anti-apoptotic proteins.

• DOI: 10.1016/j.juro.2009.05.005
• 发表时间: 2009-09
• 期刊: The Journal of urology
• 作者: White-Gilbertson SJ;Kasman L;McKillop J;Tirodkar T;Lu P;Voelkel-Johnson C
• 通讯作者: Voelkel-Johnson C