使用纳米颗粒-amphipol 进行 siRNA 的靶向和可追踪递送-猫眼课题宝

使用纳米颗粒-amphipol 进行 siRNA 的靶向和可追踪递送

批准号：

7696064

负责人：

Xiaohu Gao

金额：

$32.37万

依托单位：

UNIVERSITY OF WASHINGTON

依托单位国家：

美国

项目类别：

财政年份：

2009

资助国家：

美国

项目状态：

已结题

起止时间：

2009-08-12 至 2011-07-31

来源：

https://reporter.nih.gov/project-details/7696064

关键词：

Acids Address Amines Animals Area Biology Biomedical Engineering Cardiovascular Diseases Cell Culture Techniques Cell membrane Cells Charge Chemicals Clinical Research Complex Culture Media Cytoplasm Detection Development Dyes Electron Microscope Electrons Encapsulated Endosomes Engineering Ensure Environment Fluorescence Fostering Gene Silencing Generations Genetic Goals Gold Image Kinetics Label Life Lipid Bilayers Lipofectamine Liposomes Malignant Neoplasms Medicine Messenger RNA Molecular Nanostructures Nanotechnology Particle Size Peptides Photobleaching Plague Polyethyleneimine Preparation Property Proteins Quantum Dots RNA RNA Interference RNA Stability RNA Transport Resolution Serum Signal Transduction Silicon Dioxide Site Small Interfering RNA Specificity Structure Surface Technology Therapeutic Time TimeLine Toxic effect Viral Work base biodegradable polymer biological research cancer therapy cell fixing college cytotoxicity design fluorophore gene function human disease in vivo innovation interest medical schools nanocarrier nanoparticle nanoscale nervous system disorder particle prevent self assembly tool transmission process

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英文摘要

Silencing RNA (siRNA) is of considerable current interest in biological research because it can elicit potent, target specific knockdown of any mRNA, creating a useful and proven genetic surrogate tool. However, a key problem for effective application of this technology is specific delivery to targeted cells. The goal of this project is to develop a new generation of nanocarriers for efficient delivery of siRNA based on our recent discovery on nanoparticle-amphipol complexes. In the two year project period, we will systematically examine the chemical and structural properties of nanoparticles and their effects on siRNA delivery in cells. We will focus on fluorescent quantum dots as a discovery tool. If successful, the proposed work will aid in development of siRNA carriers for specific treatment of cancer.

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