Sensitive tumor detection with magnetomotive imaging

利用磁动成像进行灵敏的肿瘤检测

• 批准号: 8860148
• 负责人: Xiaohu Gao
• 金额: $ 46.5万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8860148
• 关键词: Academy; Acoustics; Address; Adverse effects; Animal Model; Animals; Area; Binding; Biological; Biological Markers; Biomedical Engineering; Censuses; Clinical; Code; Collaborations; Communication; Contrast Media; Coupled; Detection; Development; Diagnosis; Diagnostic; Elasticity; Electromagnetics; Engineering; Environment; Faculty; Feedback; Fostering; Future; Goals; Image; Imaging technology; Interdisciplinary Study; Lasers; Life; Magnetism; Malignant Neoplasms; Medical; Medicine; Modeling; Molecular; Monitor; Mus; Nanotechnology; Nature; Neoplasm Metastasis; Noise; Nude Mice; Optics; Performance; Phase; Positioning Attribute; Preparation; Procedures; Property; Records; Research; Research Personnel; SCID Mice; Sampling; Series; Signal Transduction; Specificity; Techniques; Technology; Technology Assessment; Temperature; Testing; Therapeutic; Therapeutic Effect; Time; Tissues; Transducers; Translations; Tumor Biology; Ultrasonography; Urology; Work; Xenograft Model; absorption; anticancer research; base; bioimaging; cancer imaging; college; contrast imaging; design; detector; effective therapy; flexibility; hyperthermia tumor treatment; image guided; image guided therapy; imaging agent; imaging modality; imaging probe; imaging system; improved; in vivo; in vivo imaging; innovation; instrument; instrumentation; medical schools; member; molecular imaging; nanobiotechnology; nanoparticle; nanoprobe; new technology; novel; outcome forecast; particle; photoacoustic imaging; prostate cancer model; research study; response; signal processing; success; targeted imaging; technology development; tumor; uptake

DESCRIPTION (provided by applicant): This application directly addresses "PQ13. Can tumors be detected when they are two to three orders of magnitude smaller than those currently detected with in vivo imaging modalities?" To date molecular imaging technologies have had limited clinical impact to date for a number of reasons. One of the primary ones is the inadequate contrast specificity of molecular contrast agents due to non-specific agent binding and background signals from tissue. Major increase in detection sensitivity would provide a fundamental change in how we diagnose and treat cancers. In this context, the overarching goal of this project is to develop an ultrasensitive platform technology based on a recent breakthrough we made on magnetomotion-based imaging-contrast enhancement (Nat. Commun. 2010). We have shown improvement of imaging S/N ratio of 3 orders or magnitude in phantoms by incorporating magnetic properties into imaging contrast agents. Through this project, we plan to further develop this innovative and powerful background suppression technique for in vivo tumor imaging and image-guided therapy. We will use photoacoustic imaging as a model, but the innovative concept and algorism can be expanded to virtually any other molecular imaging modalities involving contrast agents. This platform technology is also compatible with future major developments in the field of biomedical imaging, such as development of more specific probes and more sensitive detectors.

描述（由申请人提供）：本申请直接针对“PQ13”。当肿瘤比目前体内成像方式检测到的肿瘤小两到三个数量级时，是否可以检测到肿瘤？”到目前为止，由于一些原因，分子成像技术的临床影响有限。其中一个主要的原因是分子造影剂由于非特异性结合和来自组织的背景信号导致造影剂的造影剂特异性不足。检测灵敏度的大幅提高将从根本上改变我们诊断和治疗癌症的方式。在这种情况下，该项目的总体目标是基于我们最近在基于磁运动的成像对比度增强方面取得的突破，开发一种超灵敏的平台技术（Nat. common . 2010）。我们已经证明，通过将磁性纳入成像造影剂，可以将成像信噪比提高3个数量级。通过这个项目，我们计划进一步开发这种创新和强大的背景抑制技术，用于体内肿瘤成像和图像引导治疗。我们将使用光声成像作为模型，但创新的概念和算法可以扩展到几乎任何其他涉及造影剂的分子成像模式。该平台技术也与未来生物医学成像领域的重大发展相兼容，例如开发更特异的探针和更灵敏的探测器。

项目成果

Functional Photoacoustic Imaging of Gastric Acid Secretion Using pH-Responsive Polyaniline Nanoprobes.

使用 pH 响应聚苯胺纳米探针对胃酸分泌进行功能光声成像。

• DOI: 10.1002/smll.201601359
• 发表时间: 2016-09
• 期刊: Small (Weinheim an der Bergstrasse, Germany)
• 作者: Li J;Xiao H;Yoon SJ;Liu C;Matsuura D;Tai W;Song L;O'Donnell M;Cheng D;Gao X
• 通讯作者: Gao X

Engineering Single Nanopores on Gold Nanoplates by Tuning Crystal Screw Dislocation.

通过调整晶体螺位错在金纳米板上设计单纳米孔。

• DOI: 10.1002/adma.201703102
• 发表时间: 2017-09
• 期刊: Advanced materials (Deerfield Beach, Fla.)
• 作者: Zhai Y;Zhang F;Zhang B;Gao X
• 通讯作者: Gao X

Mitochondrial transcription factor A (TFAM) shapes metabolic and invasion gene signatures in melanoma.

• DOI: 10.1038/s41598-018-31170-6
• 发表时间: 2018-09-21
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Araujo LF;Siena ADD;Plaça JR;Brotto DB;Barros II;Muys BR;Biagi CAO Jr;Peronni KC;Sousa JF;Molfetta GA;West LC;West AP;Leopoldino AM;Espreafico EM;Silva WA Jr
• 通讯作者: Silva WA Jr

Leveraging nanotechnology for enrichment of circulating tumor cells in vivo.

利用纳米技术富集体内循环肿瘤细胞。

• DOI: 10.2217/nnm.15.99
• 发表时间: 2015
• 期刊: Nanomedicine (London, England)
• 作者: Shang,Jing;Gao,Xiaohu
• 通讯作者: Gao,Xiaohu