CORE--Analytical Chemistry

分析化学核心为中心的研究项目提供了两个重要的功能。通过微量金属成分，将对所有环境和生物样本进行分析。在某些情况下，这将需要调整或发展方法。将按照书面程序和严格的质量控制进行分析 协议。水、CHAT、土壤、房屋灰尘和空气颗粒物的环境痕量金属样本将由James Shine博士监督。Shine博士受过生物/地球化学家的培训，专门从事水和沉积物金属分析。 他将开发和验证方法，以确定金属在固体环境样品中的结合形式。顺序提取提供了有关金属生物有效性的信息。Chitra Amarasiriwardena博士专门从事包括植被在内的生物样品的痕量金属分析。Amarasiriwardena博士开发了几种分析血液、尿液和组织中砷、铅和锰的方法。 分析化学核心的第二个功能与测量和产生气溶胶有关。所有的研究项目都需要了解聊天的构成。分析化学核心将利用菲利普·德莫克里托博士、PE和史蒂夫·弗格森的工程经验，制造暴露评估所需的采样设备。他们还将设计和建造一个系统，用于生成Chat、道路粉尘、土壤和房屋粉尘的空气测试样本。该发生器可与用于项目3和4的动物暴露研究的粒子浓缩器相耦合。该声学粒子产生系统将提供一种实验室方法，用于表征与CHAT产生的气溶胶的传输和去向有关的大小分级粒子的金属含量。 分析化学核心由John Spengier博士领导，他也参与了项目1和2。Spengler教授在大气过程、室内空气污染和人体暴露评估方面的专业知识补充了其他分析化学核心关键人员的专业知识。

The Analytical Chemistry Core provides two important functions for the Center research projects. Through the trace metals component, all environmental and biological samples will be analyzed. In some cases this will require methods adaptation or development. Analysis will be performed in accordance with written procedures and in adherence to rigid quality control protocols. The environmental trace metal samples for water, chat, soils, house dust and airborne particulate matter will be overseen by James Shine, Ph.D. Dr. Shine is trained as a bio/geochemist and specializes in water and sediment metals analysis. He will develop and validate methods to determine the form in which metals are bound in the solid environmental samples. Sequential extraction provides information on biological availability of metals. Chitra Amarasiriwardena, Ph.D., specializes in trace metal analysis of biological samples including vegetation. Dr. Amarasiriwardena has developed several methods for arsenic, lead and manganese analysis in blood, urine and tissue. The second function of the Analytical Chemistry Core is related to measuring and generating aerosols. All research projects need to understand the composition of chat. The Analytical Chemistry Core, with the engineering experience of Philip Demokritou, Ph.D., PE, and Steve Ferguson, will build sampling equipment needed for exposure assessment. They will also design and construct a system for generating airborne test samples of chat, road dust, soil and house dust. The generator might be coupled to a particle concentrator for animal exposure studies of Projects 3 and 4. The acoustic particle-generating system will provide a laboratory method for characterizing metal content of size fractionated particle which is relevant to transport and fate of chat-generated aerosol. The Analytical Chemistry Core is led by John Spongier, Ph.D., who is also participating in Projects 1 and 2. Prof. Spengler's expertise in atmospheric processes, indoor air pollution and human exposure assessment complements the expertise of other Analytical Chemistry Core key staff.