Advanced Research Training in Transplantation Immunobiology

移植免疫生物学高级研究培训

• 批准号: 7658695
• 负责人: THOMAS C PEARSON
• 金额: $ 7.03万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7658695
• 关键词: Immunobiology; Research Training; Transplantation

DESCRIPTION (provided by applicant): This training grant has been created to increase excellent training of individuals in translational research who will pursue careers in basic and applied immunobiology of transplantation. Transplantation, now recognized as the optimal therapy for patients with many types of end-stage organ failure, is a highly specialized field in which immunology plays a crucial role. Future progress in organ transplantation will require the development of new classes of immunosuppressive agents associated with dramatically less toxicity but equal or greater potency than currently available regimens and the development of accurate methods of immune monitoring to assess immune responsiveness of graft recipients so that individualized immunosuppression regimens can be effectively provided. However, the field of transplantation can only fully advance if a more thorough understanding of the immune response to alloantigens, as well as to the antigens expressed by pathogenic micro-organisms and neoplastic cells, is achieved. At present, short term outcomes are improving, but consistent long term successful outcomes in transplantation are still beyond our reach. Given our current limited knowledge with respect to immunological processes in transplantation, attaining significant improvements in outcome will require a series of carefully structured studies in rodents, non-human primates, and ultimately in humans. To meet the demand to improve this field as quickly as possible, it will be necessary to recruit and retain substantially more investigators possessing both interest and expertise into the field of transplantation immunobiology, as the number of investigators in this field are currently under-represented, relative to those in other high demand fields such as oncology and cardiovascular disease research. This proposed training program seeks to recruit and rigorously train highly qualified and motivated pre-doctoral and post-doctoral candidates in translational research in transplantation immunology. It is hoped that they will pursue careers in the field of transplantation immunobiology, producing scientific advances that can be translated into improved clinical practice; thus, significantly improving the length and quality of life of transplant patients in the near future.

描述(由申请者提供)：这项培训基金的设立是为了增加对从事基础和应用移植免疫生物学研究的个人的优秀培训。移植是目前公认的多种终末期器官衰竭患者的最佳治疗方法，是一个高度专业化的领域，免疫学在其中发挥着至关重要的作用。器官移植的未来进展将需要开发毒性大大降低但效力与现有方案相同或更高的新型免疫抑制剂，并开发准确的免疫监测方法来评估移植受者的免疫反应性，以便有效地提供个性化免疫抑制方案。然而，只有更彻底地了解对同种异体抗原以及致病微生物和肿瘤细胞表达的抗原的免疫反应，移植领域才能全面发展。目前，短期结果正在改善，但移植的长期成功结果仍然遥不可及。鉴于我们目前对移植免疫过程的了解有限，要想在结果上取得显著改善，将需要在啮齿动物、非人类灵长类动物以及最终在人类身上进行一系列精心组织的研究。为了满足尽快改进这一领域的需求，有必要招聘和留住更多对移植免疫生物学领域既有兴趣又有专业知识的研究人员，因为与肿瘤学和心血管疾病研究等其他高需求领域的研究人员相比，目前该领域的研究人员数量不足。这项拟议的培训计划旨在招募和严格培训在移植免疫学翻译研究方面具有高资质和积极性的博士前和博士后候选人。希望他们从事移植免疫生物学领域的事业，产生可转化为更好的临床实践的科学进步，从而在不久的将来显著提高移植患者的生命长度和质量。