Advanced Research Training in Transplantation Science

描述(由申请者提供)：这项修订后的竞争更新旨在为继续提供移植专用培训补助金提供资金，该补助金在过去4年中已显著演变为埃默里大学移植科学高级研究培训计划。该项目服务于医学、移植生物学等领域，该领域异常严谨、独特的多学科，迫切需要新学生掌握过去20年建立起来的巨大势头。目前的建议代表了众多、高效、多样化和积极合作的初级和高级研究员/导师与相关的敬业讲师团队的结合，在基本学术卓越的强大机构基础上，执行独特和精心设计的培训计划，将吸引和留住高度积极的受训人员到移植领域，并为他们提供影响该领域普遍问题所需的独特工具集。该计划提供了丰富的环境，涵盖了移植和病毒免疫学中强大的小鼠模型，耶克斯国家灵长类中心的密集翻译计划，以及显著增加了临床试验和人类免疫学的机会。在过去的5年里，该项目的各个方面都得到了改善，学员对该项目的渴望也得到了坚定的确立。该计划在努力发展和改进方面进行了高度反省，我们坚信，目前的服务将改善移植研究和实践的未来，并优化移植受者的生存时间和质量。 与公共卫生相关：在过去的57年里，器官移植已经从一种实验性的好奇演变为治疗心脏、肠道、肾脏、肝脏、肺和内分泌胰腺的孤立终末期器官衰竭的大多数原因的首选疗法，以及四肢和其他复合组织丧失患者的新兴选择。在过去十年中，等待(目前为111,000人)、接受(28,000人/年)和与器官移植一起生活(接近400,000人)的患者数量大约翻了一番。然而，尽管需要创新的、科学合理的方法来解决与移植相关的问题的患者数量显著增加，但近年来进入该领域的科学家数量有所减少。需要新的充满活力的、以移植为重点的培训，以保持推动移植领域的发现模式，这些培训机会需要在认识到现代移植特有的独特临床整合和多学科科学和实践模式的情况下开发。协作型科学家和临床医生 为了实现这一目标，埃默里移植中心正在提出一项综合性、多学科的移植生物学培训计划(移植科学高级研究培训，ARTTS)。

DESCRIPTION (provided by applicant): This revised competitive renewal seeks funding for continuation of a transplant-specific training grant, which has evolved considerably in the past 4 years into the Advanced Research Training in Transplantation Sciences program at Emory University. The program serves an area of medical science, transplantation biology, that is exceptionally rigorous, uniquely multidisciplinary, and in dire need of new students to take up the substantial momentum established in the past 20 years. The current proposal represents a coalescence of numerous, highly productive, diverse, and actively collaborating junior and senior investigator/mentors, with an associated group of dedicated instructors, on a strong institutional foundation of fundamental academic excellence, to execute a unique and carefully designed training program that will attract and retain highly motivated trainees to the transplantation field, and give them the unique tool set needed to influence the prevailing problems in the field. The program offers a rich environment spanning powerful murine models in transplantation and viral immunology, an intensive translational program at the Yerkes National Primate Center, and markedly augmented opportunities in clinical trials and human immunology. Every aspect of the program has improved over the past 5 years and the desire for this program amongst trainees is firmly established. The program has been highly introspective in its efforts to evolve and improve, and it is our firm belief that the current offering will imprve the future of transplantation research and practice, and optimize the length and quality of life fo transplant recipients. PUBLIC HEALTH RELEVANCE: Organ transplantation has evolved over the past 57 years from an experimental curiosity to the preferred therapy for most causes of isolated end stage organ failure of the heart, intestine, kidney, liver, lung, and endocrine pancreas, as well as an emerging option for patients with limb and other composite tissue loss. The number of patients awaiting (currently >111,000), receiving (>28,000/year) and living with (approaching 400,000) organ transplants has approximately doubled in the past decade. However, even as the number of patients requiring innovative, scientifically sound solutions to transplant-related problems markedly increases, the number of scientists entering the field has decreased in recent years. Newly energized, transplant-focused training is required to perpetuate the pattern of discovery that has propelled the field of transplantation, and these training opportunities need to be developed cognizant of the unique clinical integration and multidisciplinary scientific and practice patterns characteristic of modern transplantation. Collaborative scientists and clinicians at the Emory Transplant Center are proposing an integrative, multi-disciplinary training program in transplantation biology (Advanced Research Training in Transplantation Sciences, ARTTS) to accomplish this goal.