Advanced Research Training in Transplantation Science

移植科学高级研究培训

• 批准号: 8663170
• 负责人: Mandy L Ford
• 金额: $ 8.62万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8663170
• 关键词: Research Training; Science; Transplantation

DESCRIPTION (provided by applicant): This revised competitive renewal seeks funding for continuation of a transplant-specific training grant, which has evolved considerably in the past 4 years into the Advanced Research Training in Transplantation Sciences program at Emory University. The program serves an area of medical science, transplantation biology, that is exceptionally rigorous, uniquely multidisciplinary, and in dire need of new students to take up the substantial momentum established in the past 20 years. The current proposal represents a coalescence of numerous, highly productive, diverse, and actively collaborating junior and senior investigator/mentors, with an associated group of dedicated instructors, on a strong institutional foundation of fundamental academic excellence, to execute a unique and carefully designed training program that will attract and retain highly motivated trainees to the transplantation field, and give them the unique tool set needed to influence the prevailing problems in the field. The program offers a rich environment spanning powerful murine models in transplantation and viral immunology, an intensive translational program at the Yerkes National Primate Center, and markedly augmented opportunities in clinical trials and human immunology. Every aspect of the program has improved over the past 5 years and the desire for this program amongst trainees is firmly established. The program has been highly introspective in its efforts to evolve and improve, and it is our firm belief that the current offering will imprve the future of transplantation research and practice, and optimize the length and quality of life fo transplant recipients. PUBLIC HEALTH RELEVANCE: Organ transplantation has evolved over the past 57 years from an experimental curiosity to the preferred therapy for most causes of isolated end stage organ failure of the heart, intestine, kidney, liver, lung, and endocrine pancreas, as well as an emerging option for patients with limb and other composite tissue loss. The number of patients awaiting (currently >111,000), receiving (>28,000/year) and living with (approaching 400,000) organ transplants has approximately doubled in the past decade. However, even as the number of patients requiring innovative, scientifically sound solutions to transplant-related problems markedly increases, the number of scientists entering the field has decreased in recent years. Newly energized, transplant-focused training is required to perpetuate the pattern of discovery that has propelled the field of transplantation, and these training opportunities need to be developed cognizant of the unique clinical integration and multidisciplinary scientific and practice patterns characteristic of modern transplantation. Collaborative scientists and clinicians at the Emory Transplant Center are proposing an integrative, multi-disciplinary training program in transplantation biology (Advanced Research Training in Transplantation Sciences, ARTTS) to accomplish this goal.

描述（由申请人提供）：此修订后的竞争性更新旨在为移植特定培训补助金的继续提供资金，该补助金在过去4年中已发展成为埃默里大学移植科学高级研究培训计划。该计划服务于医学科学，移植生物学，这是非常严格的，独特的多学科领域，并在新的学生采取了在过去20年中建立的实质性的势头迫切需要。目前的提案代表了众多，高效，多样化，积极合作的初级和高级研究员/导师的联合，以及相关的专门教师小组，在基础学术卓越的强大机构基础上，执行独特和精心设计的培训计划，将吸引和保留高度积极的受训者到移植领域，给他们一套独特的工具来影响这个领域的普遍问题。该计划提供了一个丰富的环境，涵盖移植和病毒免疫学中强大的小鼠模型，在耶基斯国家灵长类动物中心的密集翻译计划，并在临床试验和人类免疫学中显着增加的机会。在过去的5年里，该计划的各个方面都得到了改善，学员对该计划的渴望已经牢固确立。该计划一直在努力发展和改进，我们坚信，目前的产品将改善移植研究和实践的未来，并优化移植受者的生命长度和质量。 公共卫生相关性：在过去的57年里，器官移植已经从一种实验性的好奇心发展成为心脏、肠、肾、肝、肺和内分泌胰腺的孤立终末期器官衰竭的大多数原因的首选疗法，以及肢体和其他复合组织损失患者的新兴选择。在过去十年中，等待（目前> 111 000）、接受（> 28 000/年）和与（近400 000）器官移植一起生活的患者人数大约翻了一番。然而，尽管需要创新的、科学合理的解决方案来解决移植相关问题的患者数量显著增加，但近年来进入该领域的科学家数量却在减少。需要新的活力，以移植为重点的培训，以延续推动移植领域的发现模式，这些培训机会需要开发认识到现代移植独特的临床整合和多学科科学和实践模式。协作科学家和临床医生 在埃默里移植中心的研究人员正在提出一个综合的，多学科的移植生物学培训计划（移植科学高级研究培训，ARTTS），以实现这一目标。