Advanced Research Training in Transplantation Science

移植科学高级研究培训

• 批准号: 10642897
• 负责人: Mandy L Ford
• 金额: $ 18.13万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10642897
• 关键词: Research Training; Science; Transplantation

Abstract This competitive renewal seeks funding for years 16-20 of a successful institutional training grant focusing on the science of organ and tissue transplantation. The Advanced Research Training in Transplantation Sciences (ARTTS) program at Emory University serves an area of medical science-- transplantation biology-- that is exceptionally rigorous, uniquely multidisciplinary, and in dire need of new students to take up the substantial momentum established in the past 30 years. The application seeks to fund 1 pre-doctoral and 2 post-doctoral trainees each year, and individual appointments will last for 2 years. It seeks to produce trainees that go on to establish independent research programs in the area of transplantation biology. Since its inception in 2006, the program has successfully recruited and trained 9 pre-doctoral trainees and 14 post-doctoral trainees. Of the 6 pre-doctoral ARTTS trainees who have completed training, 100% had a first author publication as a result of their graduate research, and on average they published an impressive 4.4 first author and 6.0 total peer- reviewed manuscripts. Of the 12 past post-doctoral ARTTS trainees who have completed training, 100% had a first author publication as a result of their post-doctoral research, and on average they published 2.2 first author and 2.6 total peer-reviewed manuscripts. Furthermore, 86% of past pre-doctoral and 84% of past post- doctoral ARTTS Program trainees remain in research-intensive careers or are still in training (an additional 14% and 8% respectively are in research-related careers). Thus, the program has been highly successful in recruiting and training the next generation of transplantation scientists. The current proposal represents the continued commitment of a team of highly productive, diverse, and actively collaborating junior and senior investigator/mentors, with an associated group of dedicated instructors, on a strong institutional foundation of fundamental academic excellence, to execute a unique and carefully designed training program that will continue to attract and retain highly motivated trainees to the transplantation field, and give them the unique tool set needed to influence the prevailing problems in the field. The ARTTS Program thus now offers an incredibly rich environment spanning powerful murine models in transplantation and viral immunology, an intensive translational program at the Yerkes National Primate Center, and markedly augmented opportunities in clinical trials and human immunology. The program continues to evolve to better attract highly qualified candidates from across the country representing a diversity of races and ethnicities, and importantly now offers a research focus on health disparities among minority groups in transplantation, and a particular focus to enhancing career development in women trainees. Thus, the current offering is on the cutting edge of training in transplantation sciences, and undoubtedly will contribute to improving the future of transplantation research and practice for diverse individuals, and optimizing both length and quality of life for transplant recipients.

摘要 这一竞争性更新寻求16-20年成功的机构培训赠款的资金，重点是 器官和组织移植的科学。移植科学中的高级研究培训 埃默里大学的(ARTTS)项目服务于医学领域--移植生物学--即 格外严谨，独特的多学科，迫切需要新学生来学习实质性的 在过去的30年里建立了势头。该申请旨在资助1名博士后和2名博士后 每年受训一次，个人聘期为两年。它寻求培养出继续学习的学员 在移植生物学领域建立独立的研究计划。自2006年成立以来， 计划已成功招收和培养博士后学员9名和博士后学员14名。六个人中的 完成培训的博士前ARTTS实习生，100%拥有第一作者出版物 他们的研究生研究，平均发表了令人印象深刻的4.4第一作者和6.0总同行- 审阅手稿。在过去完成培训的12名ARTTS博士后学员中，100%的人拥有 第一作者作为博士后研究的结果发表，他们平均发表2.2第一 作者和2.6%的同行评审稿。此外，86%的博士后和84%的博士后 ARTTS博士项目实习生仍在从事研究密集型职业或仍在接受培训(额外的 分别有14%和8%从事与研究相关的职业)。因此，该方案在以下方面取得了很大成功 招募和培训下一代移植科学家。目前的提案代表了 由高效、多样化、积极协作的初级和高级团队组成的持续承诺 调查员/导师，以及相关的敬业讲师小组，拥有强大的机构基础 基本的学术成就，执行独特和精心设计的培训计划，将 继续吸引和留住积极进取的受训人员到移植领域，并为他们提供独特的 需要一套工具来影响该领域普遍存在的问题。因此，ARTTS计划现在提供了一个 在移植和病毒免疫学方面跨越强大的小鼠模型的令人难以置信的丰富环境，以及 耶克斯国家灵长类中心的密集翻译计划，显著增加了机会 在临床试验和人类免疫学方面。该计划继续发展，以更好地吸引高素质人才 来自全国各地的候选人代表了不同的种族和民族，重要的是现在提供了 研究重点是移植过程中少数群体之间的健康差距，并特别关注 加强女性实习生的职业发展。因此，目前的课程处于培训的前沿 在移植科学方面，这无疑将有助于改善移植研究的未来 并为不同的个体进行实践，并优化移植受者的生命长度和质量。

项目成果

CD57(+) CD4 T Cells Underlie Belatacept-Resistant Allograft Rejection.

• DOI: 10.1111/ajt.13613
• 发表时间: 2016-04
• 期刊: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
• 作者: Espinosa J;Herr F;Tharp G;Bosinger S;Song M;Farris AB 3rd;George R;Cheeseman J;Stempora L;Townsend R;Durrbach A;Kirk AD
• 通讯作者: Kirk AD

Impact of belatacept and tacrolimus on cytomegalovirus viral load control and relapse in moderate and high-risk cytomegalovirus serostatus kidney transplant recipients.

• DOI: 10.1111/tid.13983
• 发表时间: 2022-12
• 期刊: TRANSPLANT INFECTIOUS DISEASE
• 影响因子: 2.6
• 作者: Magua, Wairimu;Johnson, Aileen C.;Karadkhele, Geeta M.;Badell, Idelberto R.;Vasanth, Payaswini;Mehta, Aneesh K.;Easley, Kirk A.;Newell, Kenneth A.;Rickert, Joseph B.;Larsen, Christian P.
• 通讯作者: Larsen, Christian P.

The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in mice.

• DOI: 10.1002/hep.27792
• 发表时间: 2015-09
• 期刊: Hepatology (Baltimore, Md.)
• 作者: Mimche PN;Brady LM;Bray CF;Lee CM;Thapa M;King TP;Quicke K;McDermott CD;Mimche SM;Grakoui A;Morgan ET;Lamb TJ
• 通讯作者: Lamb TJ

Systems biological analyses reveal the hepatitis C virus (HCV)-specific regulation of hematopoietic development.

系统生物学分析揭示了丙型肝炎病毒（HCV）对造血发育的特异性调节。

• DOI: 10.1002/hep.27575
• 发表时间: 2015
• 期刊: Hepatology (Baltimore, Md.)
• 作者: Velazquez,VictoriaM;Uebelhoer,LukeS;Thapa,Manoj;Ibegbu,ChrisC;Courtney,Cynthia;Bosinger,StevenE;Magliocca,JosephF;Adams,AndrewB;Kirk,AllanD;Knechtle,StuartJ;Kalman,Daniel;Suthar,MehulS;Grakoui,Arash
• 通讯作者: Grakoui,Arash

Progress in kidney transplantation: The role for systems immunology.

• DOI: 10.3389/fmed.2022.1070385
• 发表时间: 2022
• 期刊: FRONTIERS IN MEDICINE
• 影响因子: 3.9
• 作者: Johnson, Aileen C.;Silva, Juliete A. F.;Kim, Steven C.;Larsen, Christian P.
• 通讯作者: Larsen, Christian P.