Role of Data Streams In Informing Infection Dynamics in Africa- INFORM Africa

项目总结/摘要 非洲的一个关键问题是缺乏人口规模的流行病学数据来源和分析能力， 快速识别和了解传染病大流行。然而，在脆弱的卫生系统和 在资源有限的情况下，对人群规模流行病学数据提供信息的需求更为迫切 传播动态和知情干预。“数据流在 非洲感染动态信息中心（INFORM Africa）旨在有效利用大数据解决 SARS CoV-2和HIV流行的紧迫公共卫生需求， 人口规模的数据流作为未来大流行病防范的基石。INFORM Africa 建议使用非洲两个受影响最严重的国家尼日利亚和南非的现有数据 占非洲大陆SARS-CoV-2感染的41%，约占其艾滋病毒负担的40%。中心被领导 由两个著名的成功的非政府组织：尼日利亚人类病毒学研究所 （IHVN）和南非艾滋病研究方案中心（CAPRISA）， 与大学及其各自的政府机构的联系，也参与。INFORM非洲也是合作伙伴 与来自该行业的私人合作伙伴- Akros赞比亚。INFORM Africa汇集了经验丰富的 研究人员在大数据分析，量子信息处理，空间 统计和分析，遗传学，计算生物学，基于代理和数据驱动的建模，临床 传染病、传染病流行病学、分子病毒学和地理空间分析， 通过四个具体目标来实现这一目标。AIM 1建立来自公共和私有的数据流 部门，以了解可能解释COVID的动态和影响的多层次相互作用， 19大流行，通过三个拟议的研究项目和两个拟议的核心，辅以试点 项目AIM 2开发地理空间工具，供国家领导层和政府在大流行病中使用 监测和反应，以改善备灾状况。AIM 3扩大了数据科学研究的机会， 通过与更广泛的DS-I非洲联盟的合作以及通过几个拟议的试点项目， 数据科学的项目。AIM 4与决策者和政府保持持续接触， 为了进一步促进对高质量数据的开放访问，以及任何产品/工具的重新分配和使用， 由非洲信息组织开发。DMAC和NGS核心是INFORM非洲的关键， 管理研究中心的数据，并提供无缝访问一组工具和工作流程，这些工具和工作流程将 更广泛的DS-I非洲开放科学数据平台和协调中心的枢纽。行政核心 协调和简化非洲信息组织的行政、财务和通信流程， 根据INFORM Africa的目标和DS-I，协调试点项目的选择 非洲的要求。项目和核心领导人组成MPD/PI领导层和 由一个科学咨询委员会支持的非洲信息网。

PROJECT SUMMARY/ABSTRACT A key problem in Africa is the paucity of population-scale epidemiologic data sources and analytical capacity to rapidly identify and understand infectious disease pandemics. Yet, in the context of fragile health systems and limited resources, the need for population-scale epidemiologic data is even more urgent to provide information on transmission dynamics and inform interventions. The overall goal of the ‘Role of Data streams In Informing infection dynamics in Africa (INFORM Africa) Hub’ is to effectively use big data to address pressing public health needs of SARS CoV-2 and HIV pandemics with the overall goal of developing population-scale data streams as a cornerstone of future pandemic preparedness. INFORM Africa proposes to use existing data from Nigeria and South Africa, the two most impacted countries in Africa accounting for 41% of the continent’s SARS-CoV-2 infection and about 40% of its HIV burden. The Hub is led by two well-established and successful non-governmental organizations: Institute of Human Virology Nigeria (IHVN) and the and the Centre for the AIDS Programme Of Research In South Africa (CAPRISA) with strong links with Universities and their respective government agencies, also engaged. INFORM Africa also partners with a private partner from the industry – Akros Zambia. INFORM Africa has assembled experienced researchers with complimentary expertise in big data analytics, quantum information processing, spatial statistics and analysis, genetics, computational biology, agent-based and data driven modelling, clinical infectious diseases, infectious disease epidemiology, molecular virology, and geospatial analytics to address the goal of this submission through four Specific Aims. AIM 1 establishes data streams from public and private sectors in order to understand the multilayer interactions that may explain the dynamics and impact of COVID- 19 pandemic, through three proposed Research Projects and two proposed Cores, supplemented by the pilot projects. AIM 2 develops geospatial tools for use by country leadership and governments in pandemic surveillance and response to improve preparedness. AIM 3 expands data science research opportunities and capacity through the engagement with the broader DS-I Africa consortium and through several proposed pilot projects in data science. AIM 4 maintains a sustained engagement with the policy makers and governments in order to promote further open access to high quality data and the redistribution and uptake of any product/tool developed by the INFORM Africa. The DMAC & NGS Core is the lynchpin of INFORM Africa, assembling and managing the Research Hub’s data and providing seamless access to a set of tools and workflows that link the Hub to the broader DS-I Africa Open Science Data Platform and coordinating center. The Administrative Core harmonizes and streamlines administrative, financial, and communication processes for INFORM Africa, and coordinates the selection of pilot projects consistent with INFORM Africa’s aims, and in compliance with DS-I Africa requirements. Project and Core leads make up the MPD/PI leadership and the Steering Committee of the INFORM Africa supported by a Scientific Advisory Board.