Interdisciplinary Training in Microbial Pathogenesis and Immunology

微生物发病机制和免疫学跨学科培训

• 批准号: 10712455
• 负责人: Scott M Landfear
• 金额: $ 37.25万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10712455
• 关键词: Immunology; Pathogenesis; Training; microbial

PROJECT SUMMARY/ABSTRACT Support is requested for a training program in microbial pathogenesis and immunology at Oregon Health & Science University (OHSU). This interdisciplinary area of research requires a cadre of interactive faculty with diverse expertise to recruit and train young scientists in all modern aspects of host-microbial interactions. Funds are requested for the support of 4 predoctoral and 2 postdoctoral trainees. The participating faculty consists of 27 members of OHSU that were selected among a pool of more than 50 available faculty based on the criteria explained in the application. Many of these investigators have primary or secondary appointments in the Department of Molecular Microbiology & Immunology, Department of Medicine, in the School of Dentistry, Biomedical Engineering, and Cell Development and Cancer Biology, and the Vaccine and Gene Therapy Institute. Thus, the necessary infrastructure in which diverse basic scientists and physician-scientists with common interests can collaborate to provide training opportunities in basic and translational research is established. The broad research programs of the participating faculty include the use of a number of vertebrate and invertebrate model hosts, the use of genetic and genomic technologies to study microbial pathogenesis and immunology, and the study of the influence of the immune system on susceptibility to infections and inflammatory disorders. In addition to an in-depth understanding of the mechanisms underlying host-pathogen interactions, the training program will offer innovative research experiences that take advantage of state-of-the- art technologies and numerous career-enhancing opportunities. The primary focus of this proposal remains the training of the next generation of scientists with an interest in microbial pathogenesis and immunology; however, there is an increasing necessity to provide training in alternative careers that will be addressed herein. Our trainees will also have the unique opportunity to obtain direct clinical experiences through the Infectious Disease Internship Program. OHSU has a number of outreach programs for underrepresented minorities that will be used to recruit a diverse group of trainees. Unfortunately, we lack a formal training mechanism for our existing predoctoral and postdoctoral trainees interested in the study of microbial pathogenesis and immunology. This training grant will help to rectify this situation and further enhance microbiology and immunology at OHSU by providing a vibrant research community with the needed infrastructure to train predoctoral and postdoctoral students in this area of research.

项目总结/摘要 请求支持俄勒冈州卫生和保健中心的微生物发病机理和免疫学培训计划。 科学大学（OHSU）。这个跨学科的研究领域需要一个互动的教师干部， 在宿主-微生物相互作用的所有现代方面招募和培训年轻科学家。 请求资金支持4名博士前和2名博士后学员。参与的教师 由OHSU的27名成员组成，这些成员是从50多名教师中选出的， 在申请中解释的标准。这些调查人员中有许多人有主要或次要任命 在分子微生物学和免疫学系，医学系，在学院 牙科、生物医学工程、细胞发育和癌症生物学、疫苗和基因 心理治疗研究所。因此，不同的基础科学家和医生科学家 有共同兴趣的人可以合作提供基础研究和转化研究的培训机会， 确立了习参与教师的广泛研究计划包括使用一些脊椎动物 和无脊椎动物模式宿主，利用遗传和基因组技术研究微生物致病机理 免疫学，研究免疫系统对感染易感性的影响， 炎症性疾病除了深入了解宿主-病原体的潜在机制外， 互动，培训计划将提供创新的研究经验，利用国家的优势， 艺术技术和众多的职业发展机会。这项建议的主要重点仍然是 培养对微生物发病机理和免疫学感兴趣的下一代科学家; 然而，越来越有必要提供替代职业培训， 本文所我们的学员也将有独特的机会获得直接的临床经验，通过 传染病实习计划。OHSU为代表性不足的人提供了一些外展计划 少数族裔将被用来招募各种各样的受训人员。不幸的是，我们缺乏正规的训练 机制，为我们现有的博士前和博士后有兴趣的研究微生物 发病机制和免疫学。这笔培训补助金将有助于纠正这种情况，并进一步加强 微生物学和免疫学在OHSU通过提供一个充满活力的研究社区所需的 基础设施，以培养在这一研究领域的博士前和博士后学生。