Body composition and breast cancer survival: immune and metabolic biomarkers in breast tumors - Disparities Supplement
身体成分和乳腺癌生存:乳腺肿瘤中的免疫和代谢生物标志物 - Disparities Supplement
基本信息
- 批准号:10712034
- 负责人:
- 金额:$ 23万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdipose tissueAdministrative SupplementBiological MarkersBlack raceBody CompositionBody fatBody mass indexBreastBreast Cancer PatientCD8-Positive T-LymphocytesCancer PrognosisCell ProliferationCollaborationsDataDiseaseDisparityDrug or chemical Tissue DistributionEligibility DeterminationEpidemiologyEthnic OriginFRAP1 geneGene ExpressionGenesGoalsHigh PrevalenceHormonalHormone ReceptorImmuneImpairmentInfrastructureIntegrated Health Care SystemsInterventionLinkMalignant NeoplasmsMammary NeoplasmsMeasuresMedicalMedical OncologyMetabolicMetabolic PathwayMetabolic dysfunctionMolecularNeighborhoodsNot Hispanic or LatinoObesityOutcomePIK3CG genePathologyPathway interactionsPatient CarePatientsPhysiologicalPre-Clinical ModelRaceResearchResearch PersonnelRetrievalRiskRisk FactorsRoleSamplingSeriesSocioeconomic StatusSpecimenT-LymphocyteTumor BiologyTumor ImmunityVisceralWaist-Hip RatioWomanWorkanalysis pipelineblack womenbreast cancer survivalcancer carecancer health disparitycancer therapycohortcomorbiditydisparity reductionethnic disparityethnic diversityexhaustexhaustionexperiencefollow-uphormone receptor-negativehuman datalifestyle interventionmalignant breast neoplasmmodifiable riskmolecular subtypesmortalityparent grantracial differenceracial disparityracial diversitystudy populationsubcutaneoussurvival predictiontherapy resistanttumortumor microenvironmenttumor progression
项目摘要
ABSTRACT
This Supplement to R01CA251589 “Body composition and breast cancer survival: immune and metabolic
biomarkers in breast tumors” responds to the PAR-22-114 “Administrative Supplements to Support Cancer
Disparity Collaborative Research.” The long-term goal is to reduce the disproportionate burden of breast
cancer mortality experienced by non-Hispanic black (NHB) women by understanding the role of a key,
modifiable risk factor: excess adiposity.
Preclinical models indicate that excess adiposity impairs anti-tumor immunity and alters metabolic and cell
proliferation pathways to promote cancer progression. Given the markedly higher prevalence of obesity (body
mass index [BMI] >30-kg/m2) in NHB vs. vs. non-Hispanic white (NHW) women, obesity is assumed to
contribute to disparities in survival. Yet, BMI does not consistently predict survival after breast cancer in NHB
women or in women hormone receptor negative breast tumors, which are more common in NHB women.
Preliminary studies suggest that more specific measures of adipose tissue distribution outperform BMI to
predict breast cancer survival. Given racial differences in adipose tissue distribution at a given BMI, there is a
need to study body composition to elucidate the role of adiposity in generating racial disparities.
This administrative supplement establishes a new collaboration between a cancer disparities expert and a
study team with expertise in epidemiology, tumor biology and breast medical oncology. The parent grant seeks
to understand how systemic factors such as patient body composition impact the local breast tumor
microenvironment and therefore breast cancer survival. With this administrative supplement, we expand those
aims to include a disparities focus by comparing NHB vs. NHW women. We will expand representation of
tumors from NHB women in our study, and conduct a series of analyses focused on racial disparities.
Specifically, we will examine: racial differences in the distribution of visceral v. subcutaneous adiposity and in
associations of these adipose tissue depots with survival (Aim 1); racial differences in the associations of each
adipose tissue depot with expression of immune and metabolic genes in the breast tumor microenvironment
(Aim 2); and racial differences in the associations of immune and metabolic genes in the breast TME with
survival (Aim 3). Potential harms of excess adiposity may be mitigated through both medical and lifestyle
interventions; thus, understanding the role of adiposity in generating racial disparities in breast cancer is a high
priority not only for research but patient care.
摘要
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Adipose tissue radiodensity and mortality among patients with nonmetastatic breast cancer.
- DOI:10.1016/j.clnu.2022.09.016
- 发表时间:2022-12
- 期刊:
- 影响因子:6.3
- 作者:Cheng, En;Caan, Bette J.;Chen, Wendy Y.;Irwin, Melinda L.;Prado, Carla M.;Feliciano, Elizabeth M. Cespedes
- 通讯作者:Feliciano, Elizabeth M. Cespedes
Adiposity and cancer survival: a systematic review and meta-analysis.
- DOI:10.1007/s10552-022-01613-7
- 发表时间:2022-10
- 期刊:
- 影响因子:0
- 作者:Cheng E;Kirley J;Cespedes Feliciano EM;Caan BJ
- 通讯作者:Caan BJ
Metabolic abnormalities and survival among patients with non-metastatic breast cancer.
- DOI:10.1186/s12885-022-10430-9
- 发表时间:2022-12-29
- 期刊:
- 影响因子:3.8
- 作者:
- 通讯作者:
Plant-Based Dietary Patterns and Breast Cancer Recurrence and Survival in the Pathways Study.
- DOI:10.3390/nu13103374
- 发表时间:2021-09-25
- 期刊:
- 影响因子:5.9
- 作者:Anyene IC;Ergas IJ;Kwan ML;Roh JM;Ambrosone CB;Kushi LH;Cespedes Feliciano EM
- 通讯作者:Cespedes Feliciano EM
Diet Quality and Breast Cancer Recurrence and Survival: The Pathways Study.
- DOI:10.1093/jncics/pkab019
- 发表时间:2021-04
- 期刊:
- 影响因子:4.4
- 作者:Ergas IJ;Cespedes Feliciano EM;Bradshaw PT;Roh JM;Kwan ML;Cadenhead J;Santiago-Torres M;Troeschel AN;Laraia B;Madsen K;Kushi LH
- 通讯作者:Kushi LH
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Elizabeth Marjorie Cespedes Feliciano其他文献
Elizabeth Marjorie Cespedes Feliciano的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Elizabeth Marjorie Cespedes Feliciano', 18)}}的其他基金
Understanding the role of adiposity and adipokine-related RNA expression in the tumor microenvironment on breast cancer outcomes in a racially and ethnically diverse sample
了解肿瘤微环境中肥胖和脂肪因子相关 RNA 表达对种族和民族多样化样本中乳腺癌结果的作用
- 批准号:
10602753 - 财政年份:2022
- 资助金额:
$ 23万 - 项目类别:
Body composition and breast cancer survival: immune and metabolic biomarkers in breast tumors
身体成分和乳腺癌生存:乳腺肿瘤中的免疫和代谢生物标志物
- 批准号:
10029647 - 财政年份:2020
- 资助金额:
$ 23万 - 项目类别:
Body composition and breast cancer survival: immune and metabolic biomarkers in breast tumors
身体成分和乳腺癌生存:乳腺肿瘤中的免疫和代谢生物标志物
- 批准号:
10198876 - 财政年份:2020
- 资助金额:
$ 23万 - 项目类别:
Informatics approaches to assessing patient frailty in surgical care
评估外科护理中患者虚弱程度的信息学方法
- 批准号:
10242206 - 财政年份:2020
- 资助金额:
$ 23万 - 项目类别:
D3-creatine dilution to determine skeletal muscle mass in colon cancer patients
D3-肌酸稀释液测定结肠癌患者的骨骼肌质量
- 批准号:
10337029 - 财政年份:2020
- 资助金额:
$ 23万 - 项目类别:
Informatics approaches to assessing patient frailty in surgical care
评估外科护理中患者虚弱程度的信息学方法
- 批准号:
10407652 - 财政年份:2020
- 资助金额:
$ 23万 - 项目类别:
Body composition and breast cancer survival: immune and metabolic biomarkers in breast tumors
身体成分和乳腺癌生存:乳腺肿瘤中的免疫和代谢生物标志物
- 批准号:
10425385 - 财政年份:2020
- 资助金额:
$ 23万 - 项目类别:
D3-creatine dilution to determine skeletal muscle mass in colon cancer patients
D3-肌酸稀释液测定结肠癌患者的骨骼肌质量
- 批准号:
10579981 - 财政年份:2020
- 资助金额:
$ 23万 - 项目类别:
Informatics approaches to assessing patient frailty in surgical care
评估外科护理中患者虚弱程度的信息学方法
- 批准号:
10652340 - 财政年份:2020
- 资助金额:
$ 23万 - 项目类别:
Body composition and breast cancer survival: immune and metabolic biomarkers in breast tumors
身体成分和乳腺癌生存:乳腺肿瘤中的免疫和代谢生物标志物
- 批准号:
10665682 - 财政年份:2020
- 资助金额:
$ 23万 - 项目类别:
相似海外基金
Deciphering the role of adipose tissue in common metabolic disease via adipose tissue proteomics
通过脂肪组织蛋白质组学解读脂肪组织在常见代谢疾病中的作用
- 批准号:
MR/Y013891/1 - 财政年份:2024
- 资助金额:
$ 23万 - 项目类别:
Research Grant
ESTABLISHING THE ROLE OF ADIPOSE TISSUE INFLAMMATION IN THE REGULATION OF MUSCLE MASS IN OLDER PEOPLE
确定脂肪组织炎症在老年人肌肉质量调节中的作用
- 批准号:
BB/Y006542/1 - 财政年份:2024
- 资助金额:
$ 23万 - 项目类别:
Research Grant
Canadian Alliance of Healthy Hearts and Minds: Dissecting the Pathways Linking Ectopic Adipose Tissue to Cognitive Dysfunction
加拿大健康心灵联盟:剖析异位脂肪组织与认知功能障碍之间的联系途径
- 批准号:
479570 - 财政年份:2023
- 资助金额:
$ 23万 - 项目类别:
Operating Grants
Determinants of Longitudinal Progression of Adipose Tissue Inflammation in Individuals at High-Risk for Type 2 Diabetes: Novel Insights from Metabolomic Profiling
2 型糖尿病高危个体脂肪组织炎症纵向进展的决定因素:代谢组学分析的新见解
- 批准号:
488898 - 财政年份:2023
- 资助金额:
$ 23万 - 项目类别:
Operating Grants
Activation of human brown adipose tissue using food ingredients that enhance the bioavailability of nitric oxide
使用增强一氧化氮生物利用度的食品成分激活人体棕色脂肪组织
- 批准号:
23H03323 - 财政年份:2023
- 资助金额:
$ 23万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of new lung regeneration therapies by elucidating the lung regeneration mechanism of adipose tissue-derived stem cells
通过阐明脂肪组织干细胞的肺再生机制开发新的肺再生疗法
- 批准号:
23K08293 - 财政年份:2023
- 资助金额:
$ 23万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A study on the role of brown adipose tissue in the development and maintenance of skeletal muscles
棕色脂肪组织在骨骼肌发育和维持中作用的研究
- 批准号:
23K19922 - 财政年份:2023
- 资助金额:
$ 23万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
Adipose Tissue T Cell Polarization and Metabolic Health in Persons Living with HIV
HIV 感染者的脂肪组织 T 细胞极化和代谢健康
- 批准号:
10619176 - 财政年份:2023
- 资助金额:
$ 23万 - 项目类别:
Estrogen Signaling in the Ventromedial Hypothalamus Modulates Adipose Tissue Metabolic Adaptation
下丘脑腹内侧区的雌激素信号调节脂肪组织代谢适应
- 批准号:
10604611 - 财政年份:2023
- 资助金额:
$ 23万 - 项目类别:
Obesity and Childhood Asthma: The Role of Adipose Tissue
肥胖和儿童哮喘:脂肪组织的作用
- 批准号:
10813753 - 财政年份:2023
- 资助金额:
$ 23万 - 项目类别:














{{item.name}}会员




