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Center to Advance Research Excellence (OPTIC)

卓越研究中心 (OPTIC)

基本信息

批准号：
10712921
负责人：
BRADLEY D STEIN
金额：
$ 255.69万
依托单位：
RAND CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-15 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10712921
关键词：
2019-nCoV Achievement Address Adopted Advocate Affect Area Buprenorphine COVID-19 pandemic Collection Communities Data Data Set Development Dimensions Disparity Disparity population Effectiveness Elements Fatality rate Fentanyl Fostering General Population Goals Grant Growth Illicit Drugs Individual Inequality Inequity Information Centers Institution Institutional Racism Knowledge Laws Lead Methodology Methods Naloxone Nature Opioid Opioid Analgesics Outcome Overdose reversal Pain management Pharmaceutical Preparations Policies Policy Maker Policy Making Policy Research Population Population Heterogeneity Public Health Research Research Personnel Resources Risk Science Series Speed Substance Use Disorder Substance abuse problem Swelling Talents Time addiction design effective therapy ethnic disparity health inequalities illicit opioid improved innovation models and simulation multidisciplinary opioid epidemic opioid overdose opioid policy opioid use disorder overdose death prescription monitoring program prescription opioid prevent racial disparity recovery services simulation social societal costs synthetic opioid tool treatment services

项目摘要

Abstract Federal and state policymakers, advocates, and community officials have implemented multiple strategies, policies, and initiatives to address dimensions of the rapidly evolving opioid crisis. There has been progress on many fronts, including increased access to medication treatment for opioid use disorder, decreased prescription of opioid analgesics, and greater access to naloxone. However, the majority of individuals with opioid use disorder do not receive the most effective treatments, and rates of fatal opioid overdose continue to grow, due in part to a shift to illicit opioids and the mixing of fentanyl with other illicit drugs. Societal costs of the crisis were an estimated $1.02 trillion in 2017. There has been a surge of opioid policy studies, many enhanced by data, tools, and methods developed by OPTIC. But policymakers and policy researchers remain challenged by the rapidly evolving nature of the crisis, including the growing recognition that the opioid crisis is increasingly a polysubstance crisis involving synthetic opioids and the acknowledgement that structural inequalities and systemic racism have exacerbated the burden for certain populations. We need new methods to help us better understand the effects of policies at the state level, and we need to understand the longer- term effects of the crisis on communities, especially how those effects are influenced by structural inequities and racial/ethnic disparities. OPTIC will continue to meet these needs, building on our achievements of the first grant cycle. We will describe in detail the policies being adopted that are likely to affect opioid-related outcomes and the evolving addiction crisis, specifically considering how particular elements differentially influence at-risk, vulnerable, and historically disadvantaged populations. We will develop resources and methods to support more robust and rigorous causal inference methods to evaluate policy effectiveness in both the short and longer term across heterogeneous populations. We will create a series of simulation tools that will inform and improve the methods opioid policy researchers and policy researchers more broadly utilize to determine which policies are most effective for whom within the opioid crises. We will also continue to rapidly and effectively disseminate resources, tools, and findings to the substance abuse research field, policymakers, other stakeholders, and the general public. Rapid collection and dissemination of reliable data and robust methods can dramatically increase the speed with which the substance abuse policy field can meet an escalating demand for science-based information. OPTIC seeks to remain a leader in that effort and to enrich its contributions as a national resource.

摘要联邦和州的政策制定者、倡导者和社区官员实施了多种战略，解决迅速演变的类阿片危机各方面问题的政策和举措。已取得进展许多方面，包括增加获得阿片类药物使用障碍的药物治疗，阿片类镇痛药的处方，以及更多地获得纳洛酮。然而，大多数人阿片类药物使用障碍没有得到最有效的治疗，致命的阿片类药物过量的比率继续上升，这一趋势在增长，部分原因是转向非法阿片类药物以及芬太尼与其他非法药物混合。社会成本危机在2017年估计为1.02万亿美元。阿片类药物政策研究激增，许多通过OPTIC开发的数据，工具和方法进行增强。但决策者和政策研究人员仍然由于危机的性质迅速演变，包括越来越多的人认识到阿片类药物危机是越来越多的涉及合成阿片类药物的多物质危机，不平等和系统性种族主义加剧了某些人口的负担。我们需要新的方法为了帮助我们更好地了解政策在国家一级的影响，我们需要了解更长的时间- 危机对社区的长期影响，特别是结构性不平等如何影响这些影响种族/民族差异。OPTIC将继续满足这些需求，建立在我们第一个赠款周期。我们将详细描述正在采取的可能影响阿片类药物相关的政策。结果和不断演变的成瘾危机，特别是考虑到特定的元素如何差异影响高危、弱势和历史弱势群体。我们将开发资源，方法来支持更强大和严格的因果推理方法，以评估政策的有效性，在不同人群中的短期和长期。我们将创建一系列模拟工具，将告知和改进阿片类药物政策研究人员和政策研究人员更广泛地利用的方法，确定哪些政策在阿片类药物危机中对谁最有效。我们还将继续迅速并有效地向药物滥用研究领域、政策制定者、其他利益相关者和公众。快速收集和传播可靠的数据，方法可以大大提高速度与物质滥用政策领域可以满足对科学信息的需求不断增加。OPTIC寻求在这一努力中保持领先地位，作为国家资源的贡献。

项目成果

期刊论文数量（41）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Assessment of State and Federal Health Policies for Opioid Use Disorder Treatment During the COVID-19 Pandemic and Beyond.

DOI：
10.1001/jamahealthforum.2021.3833
发表时间：
2021-11
期刊：
JAMA HEALTH FORUM
影响因子：
0
作者：
Pessar, Seema Choksy;Boustead, Anne;Ge, Yimin;Smart, Rosanna;Pacula, Rosalie Liccardo
通讯作者：
Pacula, Rosalie Liccardo

Effectiveness and implementability of state-level naloxone access policies: Expert consensus from an online modified-Delphi process.