Center to Advance Research Excellence (OPTIC)Center to Advance Research Excellence (OPTIC).

摘要 美国正处于阿片类药物危机之中，努力解决这一公众问题的复杂性和动态性。 健康挑战必须全面考虑多种促成因素。个国家实施了 广泛的政策和举措。然而，危机的动态性质和速度， 正在实施的不同政策方法给研究人员带来了许多挑战 评估这些努力的效果。这些挑战的部分原因是有关政策的信息有限 执行情况，关于可能影响有效性的政策特点的信息不足， 考虑所选择的分析方法如何影响同时或同时给出的结果 执行多种政策，以及关于如何最好地向决策者传达调查结果的培训有限。 为了应对这些挑战，拟议中的阿片类药物政策研究中心（COPR）将作为一个全国性的机构， 资源，促进阿片类药物政策竞技场的创新和高质量研究， 向研究界、决策者和公众传播方法、工具和信息， 公众利用COPR领导层和我们外部顾问委员会的丰富经验，COPR将 为在此政策领域工作的人员创造具有重要价值的资源。我们将开发国家级阿片类药物 政策数据库，供研究人员和决策者使用，汇集全面的阿片类药物 来自各种域的策略信息（例如，医疗保健、制药、执法）合并为一个 标准化的数据资源，提供各种政策的详细时间表以及每个政策内的政策组 状态利用这一资源，我们将对新的和 我们可以提供强有力的科学支持，证明因果效应的新兴政策层面。 通过中心对多个互补的二级数据源的访问， 与合法和非法阿片类药物相关的措施，我们将制定当地阿片类药物市场的新指标， 用于评估或监测政策在当地的影响。最后，我们将使用模拟方法， 设计一个模拟平台，开发可靠的新方法，用于识别多个、共同 发生的政策。提高对COPR结果的认识和使用，并促进与 政策制定者和更广泛的研究界，COPR将依赖于多管齐下的传播， 教育方法。中心网站将提供全面的数据库和丰富的资源， 最先进的方法和指标。面对面和在线交流和方法研讨会将 强调中心项目的主要成果，并提供培训，说明如何最好地与 非技术观众。最后，战略营销活动将提高中心数据的可见度， 药物滥用研究人员和决策者之间的研究和教育资源。

ABSTRACT The U.S. is in the midst of an opioid crisis, and efforts to tackle the complex and dynamic nature of this public health challenge must comprehensively consider a multitude of contributing factors. States have implemented a wide range policies and initiatives in response. However, the dynamic nature of the crisis and speed with which different policy approaches are being implemented pose numerous challenges for researchers evaluating the effects of such efforts. These challenges stem in part from limited information regarding policy implementation, insufficient information about policy characteristics that may influence effectiveness, little consideration of how the chosen analytic method may influence findings given simultaneous or concurrent implementation of multiple policies, and limited training on how to best communicate findings to policymakers. To address these challenges, the proposed Center for Opioid Policy Research (COPR) will serve as a national resource, fostering innovative and high-quality research in the opioid policy arena and developing and disseminating methods, tools, and information to the research community, policymakers, and the general public. Leveraging the extensive experience of COPR leadership and our External Advisory Board, COPR will create resources of significant value to those working in this policy domain. We will develop a state-level opioid policy database, accessible to both researchers and policymakers, that assembles comprehensive opioid policy information from a variety of domains (e.g., health care, pharmaceuticals, law enforcement) into a single standardized data resource that offers detailed timelines of various policies and groups of policies within each state. Drawing from this resource, we will conduct detailed assessments and documentation of new and emerging policy dimensions for which we can provide robust scientific support demonstrating causal effects. Through the Center’s access to multiple, complementary secondary data sources that capture a broad range of measures relevant to both licit and illicit opioids, we will develop new metrics of local opioid markets that can be used to evaluate or monitor impacts of policies in local areas. Finally, we will use simulation methods to design a simulation platform to develop robust new methods for identifying the joint impact of multiple, co- occurring polices. To enhance awareness and use of COPR findings and foster effective communication with policymakers and the broader research community, COPR will rely upon a multipronged dissemination and educational approach. The Center website will provide a comprehensive data repository and rich resources on state-of-the-art methods and metrics. In-person and online communication and methods workshops will highlight key Center project findings and provide training on how best to communicate research with nontechnical audiences. Finally, a strategic marketing campaign will raise visibility of the Center’s data, research and educational resources among substance abuse researchers and policymakers.