Institutional Career Development Core

机构职业发展核心

• 批准号: 10711974
• 负责人: John K. Amory
• 金额: $ 13.56万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10711974
• 关键词: Acupressure; Acupuncture Therapy; Address; Adult; Anorexia; Applications Grants; Award; Bilateral; Biological Markers; Body Weight; Body Weight Changes; Body Weight decreased; Cachexia; Cancer Patient; Cessation of life; Chronic; Chronic Kidney Failure; Chronic Obstructive Pulmonary Disease; Clinical; Collection; Congestive Heart Failure; Data; Desire for food; Development; Ear; Epidemiology; Food; Future; Inflammatory; Institution; Intervention; K-Series Research Career Programs; Malignant Neoplasms; Malignant neoplasm of pancreas; Malnutrition; Master of Science; Mentors; Mentorship; Needles; Outpatients; Participant; Patient Outcomes Assessments; Patients; Plants; Population; Prevention; Provider; Quality of life; Randomized; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Risk Factors; Techniques; Time; Training; Vaccaria; acceptability and feasibility; appetite loss; arm; career; career development; design; efficacious intervention; experience; feasibility trial; gastroesophageal cancer; improved; infection risk; malignant stomach neoplasm; multidisciplinary; novel; pancreatic cancer patients; pilot trial; prevent; standard care; treatment adherence

This proposed KL2 supplement award will provide Dr. Blake Langley, ND, MS, LAc with the necessary protected time, resources, didactic training, and mentored guidance from an interdisciplinary team to develop into an independent researcher. The planned completion of a master's degree in Epidemiology is a critical component to achieving independence as a researcher. The intensive mentorship, pragmatic experience, and clinical-didactic training over three years will provide fundamental training to a clinician-scholar in the design, collection, analysis, and interpretation of both mechanistic biomarker data and patient-reported outcomes. The proposed research project will generate preliminary data for future grant applications addressing the prevention and treatment of a serious illness: anorexia, the abnormal loss of appetite for food. Anorexia contributes to malnourishment and is a predecessor to cachexia (weight loss >5% of total body weight) in cancer, chronic obstructive pulmonary disease, chronic kidney disease, and congestive heart failure. Cachexia is implicated in up to 20% of cancer-related deaths, poses a risk to an estimated 60-70% of patients with pancreatic and gastric cancer, and is associated with negative impacts on quality of life, treatment adherence, and overall survival. A growing body of research supports acupuncture as an efficacious intervention for anorexia, while auricular acupressure, an acupuncture technique without infection risk that uses seeds from the Vaccaria segetalis plant, may target multiple mechanisms of actions that address cachexia risk factors. Auricular acupressure interventions must consider the feasibility and acceptability to specific populations, including patients and providers. The broad objective of the scholar's research project is to train an early career investigator on the design, conduct, and analysis of a pilot and feasibility trial of an auricular acupressure intervention delivered in a multidisciplinary outpatient setting. The proposed study is an 8-week randomized, controlled pilot and feasibility trial of auricular acupressure plus standard care (active arm) vs standard care only (control arm). Auricular acupressure ear seeds will be applied weekly and maintained for five days after each application for 8 weeks. Participants will gently stimulate each seed bilaterally for three minutes, three times per day. The primary aim of the trial is to assess the feasibility and acceptability of an auricular acupressure intervention to improve appetite prevent weight loss in 66 adults with pancreatic and gastroesophageal cancer with low appetite. The secondary aim is to estimate the effect size and variance in weight loss and change in appetite for future studies on the efficacy of auricular acupressure in cancer patients with low appetite. The exploratory aim will examine potential inflammatory mechanisms by which auricular acupressure impacts weight loss and appetite, and the intervention's impact on quality of life. The results of this trial will inform future studies on the efficacy of such an intervention and should be applicable to future research on anorexia and cachexia in both cancer and non-cancer populations.

这一拟议的KL 2补充奖将为Blake兰利博士，ND，MS，LAc提供必要的 保护时间，资源，教学培训，并从一个跨学科的团队指导，以发展 成为一名独立研究员计划完成流行病学硕士学位是一个关键 作为一名独立的研究人员。密集的指导，务实的经验， 三年以上的临床教学培训将为临床医生学者提供设计方面的基本培训， 收集、分析和解释机械生物标志物数据和患者报告的结果。的 拟议的研究项目将产生初步数据，用于未来的赠款申请， 和治疗一种严重的疾病：厌食症，不正常的食欲不振的食物。厌食症有助于 营养不良，是癌症、慢性癌症和慢性癌症中恶病质（体重减轻>总体重的5%）的前身。 阻塞性肺病、慢性肾病和充血性心力衰竭。恶病质与 高达20%的癌症相关死亡，对估计60-70%的胰腺癌患者构成风险， 胃癌，并与生活质量，治疗依从性和整体的负面影响有关。 生存越来越多的研究支持针灸作为厌食症的有效干预， 耳穴按压，一种没有感染风险的针灸技术，使用王不留行的种子 Segetalis植物，可以针对解决恶病质风险因素的多种作用机制。耳廓 穴位按摩干预必须考虑特定人群的可行性和可接受性，包括 患者和供应商。这位学者的研究项目的主要目标是培养一个早期的职业生涯 设计、实施和分析耳穴按压的试点和可行性试验的研究者 在多学科门诊环境中进行干预。这项研究是一项为期8周的随机， 耳穴按压加标准护理（主动组）与标准护理的对照试验和可行性试验 仅（控制臂）。耳穴压耳种子将适用于每周和维持五天后， 每次申请8周。参与者将轻轻地刺激每颗种子双边三分钟，三 次。试验的主要目的是评估耳道植入的可行性和可接受性。 穴位按摩干预，以改善食欲，防止体重减轻66名成人胰腺和 胃食管癌伴食欲不振第二个目的是估计效应大小和方差， 体重减轻和食欲改变，以供将来研究耳穴按压对癌症患者的疗效 食欲不振探索性目标将检查耳道炎症的潜在炎症机制 穴位按摩影响体重减轻和食欲，以及干预对生活质量的影响。的结果 这项试验将为未来关于这种干预的有效性的研究提供信息，并应适用于未来的研究。 癌症和非癌症人群中厌食症和恶病质的研究。