Institutional Career Development Core

了解唐氏综合征的终生共生状况调查(包括) 补充将支持一位有前途的早期职业调查员汉娜·雷亚，以扩大她的研究和 唐氏综合征并发行为和认知障碍的相关临床经验。在这些人中 与Down相关的最常见、最常见的生活质量受损和研究不足的行为表型 综合症是具有挑战性的行为，如攻击性或不服从。具有挑战性的行为 对唐氏综合症患者及其家人的长期负面影响，包括贡献 这是因为对全球运作和独立至关重要的技能的获得减少。建议数 该项目旨在确定和分析儿童挑战行为的风险因素的交互影响 唐氏综合症，这将为干预提供信息。 这个项目将调查非语言智商和语言智商作为挑战行为严重性的预测因子， 对120名6至14岁的唐氏综合症儿童进行了执行功能的调节。可行性 将与10个唐氏综合症儿童家庭和5个成年人一起评估措施的可接受性 对于唐氏综合征和潜在建模，将使用多模式措施来操作EF和 具有挑战性的行为。同样的模型将在自闭症儿童的档案样本中进行调查 谱系障碍(ASD)，是一种在常见的共生情况下重叠的疾病，发生在 唐氏综合症儿童的高患病率。档案样本包括已知患有 与伴有(n=125)或不伴有智力障碍(n=87)的ASD和DYRK1A相关的遗传病因学 突变，唐氏综合征候选基因(n=27)，年龄3-24岁。与ASD的比较将告诉我们 针对自闭症儿童的现有循证干预措施是否适用于唐氏症儿童 综合症。 瑞博士将加入转化性健康科学研究所(总部设在华盛顿大学) 作为KL2学者，并接受大学高素质高级调查团队的指导 华盛顿大学、西雅图儿童医院和加州大学戴维斯心智研究所。通过 KL2计划，Rea博士将通过互动教学获得翻译科学方面的知识和技能 与多学科KL2队列的会议。此外，Rea博士将寻求在研究方面进行强化培训 唐氏综合征儿童及其家庭、儿童电生理学方法和高级 结构方程建模的统计培训。拟议的机制将支持她的进步 建立自己的实验室并申请独立研究资金以支持未来 唐氏症儿童挑战行为轨迹及干预的临床研究 综合症。

The INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndrome (INCLUDE) supplement will support a promising early career investigator, Hannah Rea, to broaden her research and related clinical experience in behavioral and cognitive disorders co-occurring with Down syndrome. Among the most common, quality-of-life impairing, and understudied behavioral phenotypes associated with Down syndrome are challenging behaviors, such as aggression or noncompliance. Challenging behaviors have negative long-term consequences for individuals with Down syndrome and their families, including contributing to decreased acquisition of skills that are critical for global functioning and independence. The proposed project aims to identify and analyze the interacting effects of risk factors for challenging behaviors in children with Down syndrome, which will inform interventions. This project will investigate nonverbal and verbal IQ as predictors of severity of challenging behaviors, moderated by executive functioning in 120 children with Down syndrome ages 6 to 14 years. The feasibility and acceptability of measures will be assessed with 10 families of children with Down syndrome and 5 adults with Down syndrome and latent modeling and multi-modal measures will be used to operationalize EF and challenging behaviors. The same models will be investigated in an archival sample of children with autism spectrum disorder (ASD), a disorder that overlaps in commonly co-occurring conditions and occurs in heightened prevalence in children with Down syndrome. The archival sample includes children with a known genetic etiology associated with ASD with (n=125) or without (n=87) intellectual disability, and with a DYRK1A mutation, a candidate gene for Down syndrome (n=27), ages 3 to 24 years. The comparison to ASD will inform whether existing evidence-based interventions for children with ASD may be adapted for children with Down syndrome. Dr. Rea will join the Institute of Translational Health Sciences (based at the University of Washington) as a KL2 scholar and receive mentorship from a highly qualified team of senior investigators at the University of Washington, Seattle Children’s Hospital, and the University of California, Davis MIND Institute. Through the KL2 program, Dr. Rea will gain knowledge and skills in translational science through interactive didactic sessions with the multidisciplinary KL2 cohort. Additionally, Dr. Rea will seek intensive training in research with children with Down syndrome and their families, electrophysiology methods with children, and advanced statistical training in structural equation modeling. The proposed mechanism will support her progression towards establishing her own laboratory and applying for independent research funding to support a future clinical trial investigating the trajectory of and interventions for challenging behaviors in children with Down syndrome.