Cancer Epidemiology, Prevention and Control Program

癌症流行病学、预防和控制计划

基本信息

批准号：
10712882
负责人：
H Dean Hosgood
金额：
$ 5.61万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-06-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10712882
关键词：
Address Advanced Malignant Neoplasm Affect Articulation Back Behavioral Biological Biological Models Black race Cancer Burden Cancer Center Cancer Center Support Grant Cancer Control Cancer Etiology Cancer Patient Catchment Area Cervical Cancer Screening Clinical Clinical Data Collaborations Communities Community Outreach County Detection Development Disparity Early Diagnosis Effectiveness Ensure Epigenetic Process Etiology Evolution Genetic Goals Guidelines HIV Health Health Personnel Health Services Accessibility Health system Home Human Human Papillomavirus Incidence Individual Inequity Institution International Intervention Laboratories Language Latinx Leadership Malignant Neoplasms Malignant neoplasm of cervix uteri Malignant neoplasm of lung Malignant neoplasm of prostate Mentors Minority Mission Modeling Molecular NCI Center for Cancer Research Nature New York Obesity associated cancer Organ Outcome Participant Patients Peer Review Personal Satisfaction Persons Play Policies Population Population Heterogeneity Population Research Population Study Poverty Predisposition Prevention Principal Investigator Productivity Public Health Public Health Practice Quality of life Research Research Design Research Personnel Risk Factors Role Shapes Statistical Methods Strategic Planning Supportive care Testing Tobacco smoking behavior Training Translating Translations Variant Vulnerable Populations Western Africa Work anticancer research cancer care cancer education cancer epidemiology cancer health disparity cancer prevention care delivery care outcomes clinical practice community engagement community involvement community setting design effectiveness testing electronic medical record system equity, diversity, and inclusion fire fighter health inequalities high risk high risk population improved infection related cancer innovation malignant breast neoplasm member mortality multiple chronic conditions non-smoker novel novel therapeutic intervention outreach patient retention prevent programs psychosocial screening smoking intervention social social determinants social health determinants trend tumor virtual

项目摘要

Program Director/Principal Investigator (Last, First, Middle): Chu, Edward CANCER EPIDEMIOLOGY, PREVENTION AND CONTROL PROGRAM – PROJECT SUMMARY/ABSTRACT The Cancer Epidemiology, Prevention and Control (CEPC) Program plays a central role in the scientific, clinical, and public health mission of MECC. The Program’s overarching goal is to better understand and address drivers of cancer burden and cancer disparities in our Bronx catchment area and other vulnerable populations. Program investigators focus on studies in human populations to determine the behavioral, environmental, and molecular risk factors that underlie cancer etiology and outcomes, leading to studies that devise, implement and test the effectiveness of novel interventions to promote cancer prevention, screening, treatment and supportive care. Program members collaborate extensively with one another and with the other three MECC research programs. Given the inter- and trans-disciplinary nature of this program, CEPC is the focal point for translating laboratory- based research into population level studies and for bridging findings from clinical and community settings back to the lab. CEPC has three specific aims: (1) to characterize the risk factors that drive cancer health disparities in our catchment area, most notably breast, lung, prostate, and cervical cancer; (2) to improve cancer prevention and screening among vulnerable and high-risk groups in our catchment area and beyond; and (3) to develop and implement innovative strategies to enhance cancer care outcomes. CEPC research has contributed to improved health of the largely poor and minoritized Bronx population, as well as populations worldwide. Completed and ongoing research in CEPC has substantively influenced clinical guidelines and public health practice, with new studies poised to continue this trend. CEPC research: (i) has identified novel susceptibility markers for breast cancer, prostate cancer, CRC, and lung cancer in non-smokers -- the major causes of cancer mortality in the Bronx – demonstrating efforts to understand the mechanisms of cancer in an environmental and behavioral context; (ii) contributed to major policy decisions regarding cancer care of firefighters who worked at the 9/11 WTC; (iii) developed innovative in-reach and outreach strategies that overcome social determinants to increase early detection and timely access to care; (iv) developed effective tobacco smoking interventions that have been integrated in to standard clinical practice, as well as in clinical guidelines for persons living with HIV; (v) implemented comprehensive cervical cancer screening and treatment in Western Africa; and (vi) introduced a novel appraisal paradigm that emphasizes patients’ own personal criteria for quality of life. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page

计划主任/首席研究员（最后，第一，中间）：楚，爱德华癌症流行病学，预防和控制计划 - 项目摘要/摘要癌症流行病学，预防和控制（CEPC）计划在科学，临床，和MECC的公共卫生任务。该计划的总体目标是更好地理解和解决驱动因素我们的布朗克斯集水区和其他脆弱人群的癌症伯恩和癌症差异。程序研究人员专注于人类人群的研究，以确定行为，环境和分子癌症病因和结果的危险因素，导致研究，实施和测试的研究新型干预措施的有效性，以促进预防癌症，筛查，治疗和支持性护理。计划成员相互广泛合作，并与其他三个MECC研究计划进行了合作。鉴于该计划的跨学科性质和跨学科性质，CEPC是翻译实验室的焦点 - 基于人口水平研究的研究以及从临床和社区环境中桥接发现的研究到实验室。 CEPC具有三个特定的目标：（1）表征驱动癌症健康分布的危险因素在我们的集水区，最著名的是乳房，肺，前列腺和宫颈癌。（2）改善预防癌症并在我们的集水区及其他地区筛选脆弱和高风险的群体；（3）发展并实施创新策略来增强癌症护理结果。 CEPC研究有助于在全球范围内较贫穷和少数的布朗克斯人口以及人口的健康状况得到改善。在CEPC完成和正在进行的研究已实质上影响了临床准则和公共卫生练习，新研究中毒以继续这一趋势。 CEPC研究：（i）已经确定了新的易感性非吸烟者的乳腺癌，前列腺癌，CRC和肺癌的标记 - 癌症的主要原因布朗克斯的死亡率 - 展示了了解环境中癌症机制的努力行为背景；（ii）为在工作的消防员的癌症护理方面做出了重大政策决定 9/11 WTC; （iii）制定了创新的方面和外展策略，以克服社会决定者增加早期检测并及时获得护理；（iv）开发了有效的烟草吸烟干预措施已纳入标准临床实践，以及针对艾滋病毒患者的临床指南；（v）在西非实施了全面的宫颈癌筛查和治疗；（vi）引入一种新颖的评估范式，强调患者自己的生活质量标准。 OMB No. 0925-0001/0002（修订版03/2020通过02/28/2023批准）页面