Assessing the Relative and Absolute Risk for site-Specific Cancer Mortality attributed to Household Air Pollution

评估家庭空气污染导致的特定地点癌症死亡率的相对和绝对风险

• 批准号: 10252046
• 负责人: H Dean Hosgood
• 金额: $ 37.21万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-02 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10252046
• 关键词: Accounting; Address; Asia; Biomass; Burn injury; Calendar; Carcinogens; Case-Control Studies; Cessation of life; Coal; Cohort Studies; Data; Disease; Environmental Risk Factor; Epidemiology; Esophagus; Etiology; Exposure to; Family; Female; Fibrinogen; Genes; Genetic; Genetic Variation; Geographic Locations; Geography; Health; Heterogeneity; Household; Household Air Pollution; Human; Individual; International Agency for Research on Cancer; Larynx; Lead; Lung; Malignant Neoplasms; Malignant neoplasm of esophagus; Malignant neoplasm of larynx; Malignant neoplasm of lung; Malignant neoplasm of nasopharynx; Malignant neoplasm of pharynx; Measures; Methods; Modeling; Nitrogen Dioxide; North America; Oropharyngeal; Participant; Policies; Population; Population Attributable Risks; Positioning Attribute; Process; Prospective Studies; Prospective cohort; Public Health; Questionnaires; Recording of previous events; Regulation; Relative Risks; Research; Resources; Risk; Risk Estimate; Risk Factors; Sample Size; Site; Smoker; Smoking Status; Statistical Methods; Time; Tobacco smoke; Tobacco smoking behavior; Wood material; ambient air pollution; base; burden of illness; cancer risk; cancer site; carcinogenicity; coarse particles; cohort; design; disorder risk; environmental tobacco smoke; experience; fine particles; genetic variant; genome wide association study; male; malignant mouth neoplasm; mortality; multiple data sources; never smoker; novel; prospective; pulmonary function; sex; smoking exposure; solid fuel

Household air pollution (HAP) attributed to wood use is a potential environmental risk factor for lung cancer, to which ~2.5 billion people worldwide (including >15 million in the US) are exposed. Known lung cancer risk factors (i.e., environmental tobacco smoke (ETS), outdoor air pollution (OAP), family history) do not fully account for the disease burden. To reach robust conclusions about biomass's pulmonary carcinogenicity and the lung cancer deaths attributed to HAP while accounting for confounding exposures, prospective studies of individuals experiencing a variety of exposure levels of HAP, ETS, and other suspected lung carcinogens are needed. We will leverage our global consortium of prospective studies (HAPCO: Household Air Pollution Cohorts), which is a pooled resource of >550,000 subjects, to for the first time accurately quantify the relative risk of lung cancer mortality associated with wood use. Further, we will estimate time-dependent population-attributable fraction (PAF) function for lung cancer mortality, which will measure the potential reduction in lung cancer mortality if HAP is eliminated or reduced while adjusting for known and suspected lung carcinogens (i.e., ETS, OAP). Our robust harmonization of HAP data will also provide the unique opportunity to determine the relative and absolute risks associated with HAP exposures for cancers other than lung cancer, which was recently highlighted by an expert panel convened by multiple US Federal Agencies.

由于木材使用造成的家庭空气污染（HAP）是肺癌的潜在环境风险因素， 全世界约有25亿人（包括美国的1500万人）暴露于此。已知的肺癌风险因素 (i.e.,环境烟草烟雾（ETS），室外空气污染（OAP），家族史）不能完全解释 疾病负担。得出关于生物质的肺致癌性和肺癌死亡的可靠结论 在考虑混杂暴露的同时，对经历HAP的个体进行的前瞻性研究表明， HAP、ETS和其他可疑的肺致癌物的各种暴露水平是必要的。我们将利用我们 全球前瞻性研究联盟（HAPCO：家庭空气污染队列），这是一个汇集的资源 在> 550，000名受试者中，首次准确量化与肺癌死亡率相关的相对风险。 木材的使用。此外，我们将估计肺的时间依赖性人群归因分数（PAF）功能， 癌症死亡率，它将衡量消除或减少HAP后肺癌死亡率的潜在降低 同时调整已知的和可疑的肺致癌物（即，ETS、OAP）。我们对HAP数据的强大协调 还将提供确定与HAP暴露相关的相对和绝对风险的独特机会 对于肺癌以外的癌症，最近由美国多个国家召集的专家小组强调了这一点。 联邦机构。