CTSA Predoctoral T32 at Albert Einstein College of Medicine

摘要 此申请旨在继续CTSA支持的长期博士前项目--临床博士学位 阿尔伯特·爱因斯坦医学院(爱因斯坦)的研究(PCI)。PCI结合了专业培训，以 培养生物医学科学家理解和欣赏临床和人群的方法学 科学，实践团队科学作为研究团队的领导者和成员，并推动 翻译科学的学科。PCI利用爱因斯坦在基础实验室方面的长期成功- 基础研究。PCI与我们授予硕士学位的临床研究培训的独特结合 计划(CRTP)，以及我们的要求，即每个学生的研究和指导团队必须 翻译鸿沟“，培养多学科团队科学，同时教授要克服的方法论 困扰翻译研究的障碍。PCI已(1)授予18个博士学位，(2)12名当前实习生，(3)持续 招收来自历史边缘化社区(HMCS)的受训人员，以及(4)大幅增加 询问和申请者。爱因斯坦位于纽约州布朗克斯区，这是世界上最多样化、最贫穷的城市县 美国，其集水区在与以下方面有关的健康结果方面存在种族和民族差异 癌症、心血管疾病和传染病。由于我们受训人员的大部分研究都涉及到患者 来自我们集水区的数据和样本，PCI基本上一直在培训学员进行临床和 翻译科学(TS)研究对我们理解和缓解 不成比例地影响HMCS的差距。在我们项目的成功和需求增长的基础上， 我们寻求在下一个资助期发展PCI，正式强调整合卫生公平 (他)加入我们的培训和确保计划的可持续性。我们将把健康差距研究与 通过与社区和利益相关者的合作，将重点放在克服高等教育障碍上 我们的合作伙伴CTSA UM1的交战研究模块。我们将加强对下一代的培训 对受新冠肺炎疫情不利影响的受训者，通过建立 学生支持副主任。我们将通过开发特定于PCI的F-奖来提高可持续性 提交程序的路径。虽然经皮冠状动脉介入治疗与疾病无关，但我们的许多受训人员都进行了 与我们的集水区高度相关的研究，特别是与传染病、癌症和 脑科学。在下一个资助期内，我们寻求利用非专门性的pci，并开发新的 传染病、癌症预后和脑科学的研究重点领域，高度整合 资助导师，并提供机会将额外的针对疾病的T32赠款带入PCI，提供 通过此应用程序寻求的四个疾病不可知插槽之外的资助机会。 虽然我们的培训方法仍将是非绝对的，但在下一个项目期间，我们将努力强调 这些重点领域根据我们的机构优势，同时将TS和HE镜头应用到所有学员的项目中。

ABSTRACT This application seeks to continue a longstanding CTSA-supported predoctoral program, the PhD in Clinical Investigation (PCI) at the Albert Einstein College of Medicine (Einstein). PCI combines specialized training to prepare biomedical scientists to understand and appreciate the methodologies of clinical and population science, to practice team science as both leaders and members of research teams, and to advance the discipline of translational science. PCI leverages Einstein's longstanding success in fundamental laboratory- based research. PCI's unique integration with our master's degree-granting Clinical Research Training Program (CRTP), along with our requirement that each student's research and mentoring team must “bridge a translational divide,” fosters multidisciplinary team science while teaching the methodologies to overcome barriers plaguing translational research. PCI has (1) conferred 18 PhDs, (2) 12 current trainees, (3) sustained enrollment of trainees from historically marginalized communities (HMCs), and (4) a dramatic increase in inquiries and applicants. Einstein is located in the Bronx, NY, the most diverse and poorest urban county in the United States, whose catchment area experiences racial and ethnic disparities in health outcomes related to cancer, cardiovascular disease, and infectious diseases. Since much of our trainees' research involves patient data and samples from our catchment area, PCI has essentially been training trainees to conduct clinical and translational science (TS) research that meaningfully contributes to our understanding and mitigation of disparities that disproportionately affect HMCs. Building from our program's success and increased demand, we seek to evolve PCI during the next funding period with formalized emphasis on integrating health equity (HE) into our training and ensuring program sustainability. We will integrate health disparities research with a focus on overcoming barriers to HE into our training though collaboration with the Community and Stakeholder Engagement Research Module of our companion CTSA UM1. We will improve training of the next generation of trainees, who have been unfavorably affected by the COVID-19 pandemic, by establishing the position of Associate Director for Student Support. We will improve sustainability by developing a PCI-specific F-award path to submission program. While the PCI is disease-agnostic, many of our trainees have undertaken research that is highly relevant to our catchment area, particularly in relation to infectious disease, cancer, and brain science. During the next funding period, we seek to leverage the non-categorical PCI and develop new Research Focus Areas in Infectious Disease, Cancer Outcomes, and Brain Sciences, to integrate highly funded mentors and provide the opportunity to bring additional disease-specific T32 grants into PCI, providing PCI trainees funding opportunities beyond the four disease-agnostic slots sought through this application. While our training approach will remain non-categorical, in the next project period we will seek to emphasize these focus areas per our institutional strengths, while applying TS and HE lenses to all trainees' projects.