CTSA Predoctoral T32 at Albert Einstein College of Medicine

阿尔伯特·爱因斯坦医学院 CTSA 博士前 T32

• 批准号: 10704924
• 负责人: H Dean Hosgood
• 金额: $ 22.74万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-06 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10704924
• 关键词: Medicine; college; pre-doctoral

ABSTRACT This application seeks to continue a longstanding CTSA-supported predoctoral program, the PhD in Clinical Investigation (PCI) at the Albert Einstein College of Medicine (Einstein). PCI combines specialized training to prepare biomedical scientists to understand and appreciate the methodologies of clinical and population science, to practice team science as both leaders and members of research teams, and to advance the discipline of translational science. PCI leverages Einstein's longstanding success in fundamental laboratory- based research. PCI's unique integration with our master's degree-granting Clinical Research Training Program (CRTP), along with our requirement that each student's research and mentoring team must “bridge a translational divide,” fosters multidisciplinary team science while teaching the methodologies to overcome barriers plaguing translational research. PCI has (1) conferred 18 PhDs, (2) 12 current trainees, (3) sustained enrollment of trainees from historically marginalized communities (HMCs), and (4) a dramatic increase in inquiries and applicants. Einstein is located in the Bronx, NY, the most diverse and poorest urban county in the United States, whose catchment area experiences racial and ethnic disparities in health outcomes related to cancer, cardiovascular disease, and infectious diseases. Since much of our trainees' research involves patient data and samples from our catchment area, PCI has essentially been training trainees to conduct clinical and translational science (TS) research that meaningfully contributes to our understanding and mitigation of disparities that disproportionately affect HMCs. Building from our program's success and increased demand, we seek to evolve PCI during the next funding period with formalized emphasis on integrating health equity (HE) into our training and ensuring program sustainability. We will integrate health disparities research with a focus on overcoming barriers to HE into our training though collaboration with the Community and Stakeholder Engagement Research Module of our companion CTSA UM1. We will improve training of the next generation of trainees, who have been unfavorably affected by the COVID-19 pandemic, by establishing the position of Associate Director for Student Support. We will improve sustainability by developing a PCI-specific F-award path to submission program. While the PCI is disease-agnostic, many of our trainees have undertaken research that is highly relevant to our catchment area, particularly in relation to infectious disease, cancer, and brain science. During the next funding period, we seek to leverage the non-categorical PCI and develop new Research Focus Areas in Infectious Disease, Cancer Outcomes, and Brain Sciences, to integrate highly funded mentors and provide the opportunity to bring additional disease-specific T32 grants into PCI, providing PCI trainees funding opportunities beyond the four disease-agnostic slots sought through this application. While our training approach will remain non-categorical, in the next project period we will seek to emphasize these focus areas per our institutional strengths, while applying TS and HE lenses to all trainees' projects.

抽象的 该申请旨在继续 CTSA 支持的长期博士前项目，即临床博士学位 阿尔伯特·爱因斯坦医学院（Einstein）的调查（PCI）。 PCI 结合专业培训 帮助生物医学科学家理解和欣赏临床和人群的方法 科学，作为研究团队的领导者和成员实践团队科学，并推进 转化科学学科。 PCI 利用了爱因斯坦在基础实验室的长期成功—— 基础研究。 PCI 与我们授予硕士学位的临床研究培训的独特整合 计划（CRTP），以及我们要求每个学生的研究和指导团队必须“桥接一个 转化鸿沟”培养多学科团队科学，同时教授克服的方法 困扰转化研究的障碍。 PCI 已 (1) 授予 18 名博士学位，(2) 12 名现任学员，(3) 持续 来自历史边缘化社区 (HMC) 的学员入学人数，以及 (4) 学员人数急剧增加 查询和申请人。爱因斯坦位于纽约州布朗克斯，这是美国最多元化和最贫困的城市县 美国，其集水区在与健康相关的结果方面存在种族和民族差异 癌症、心血管疾病和传染病。由于我们学员的大部分研究都涉及患者 PCI 本质上是在培训学员进行临床和 转化科学（TS）研究对我们理解和缓解 差异对 HMC 产生了不成比例的影响。基于我们计划的成功和需求的增加， 我们寻求在下一个资助期内发展 PCI，并正式强调整合健康公平 (HE) 参与我们的培训并确保计划的可持续性。我们将把健康差异研究与 通过与社区和利益相关者的合作，专注于克服高等教育进入我们培训的障碍 我们的配套 CTSA UM1 的参与研究模块。我们将改善下一代的培训 受 COVID-19 大流行不利影响的学员，通过建立 学生支持副主任。我们将通过制定 PCI 特定 F 奖来提高可持续性 提交程序的路径。虽然 PCI 与疾病无关，但我们的许多学员已经接受了 与我们的学区高度相关的研究，特别是与传染病、癌症和 脑科学。在下一个资助期间，我们寻求利用非分类 PCI 并开发新的 研究重点领域为传染病、癌症结果和脑科学，以高度整合 资助导师并提供机会将额外的特定疾病 T32 资助纳入 PCI，提供 PCI 学员通过此申请寻求的资助机会超出了四个与疾病无关的名额。 虽然我们的培训方法将保持非绝对性，但在下一个项目期间，我们将力求强调 这些重点领域符合我们的机构优势，同时将 TS 和 HE 镜头应用于所有学员的项目。