Airborne metals, neurodegeneration, and dementia in the Adult Changes in Thought study
成人思想变化研究中的空气金属、神经退行性变和痴呆
基本信息
- 批准号:10717419
- 负责人:
- 金额:$ 65.84万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-15 至 2028-06-30
- 项目状态:未结题
- 来源:
- 关键词:AdultAgingAir PollutantsAir PollutionAlzheimer&aposs DiseaseAnatomyApolipoprotein EAutopsyBehaviorBehavioralBiometryBrainBrain regionCerebellumCerebrovascular DisordersCerebrovascular TraumaCessation of lifeClinicalCognitionCognitiveCollaborationsConsensusConsentCoupledDSM-IVDataDementiaDiagnosisDisciplineDiseaseElderlyEnrollmentEpidemiologyEthnic OriginEvaluationExposure toGenderGenotypeGliosisHealthHealth Care CostsHumanImpaired cognitionInterventionKnowledgeLewy BodiesLewy Body DiseaseLife StyleMass Spectrum AnalysisMeasuresMediatingMediationMetal exposureMetalsModelingModificationMorbidity - disease rateNerve DegenerationOlfactory PathwaysOlfactory tractOutcomeParticipantPathologicPathologyPathway AnalysisPathway interactionsPharmaceutical PreparationsPlasmaPopulationProspective, cohort studyPsychometricsRaceRecording of previous eventsResearchResourcesRiskRisk FactorsSamplingScanning Electron MicroscopyScienceTestingToxicologyUnited StatesVascular DiseasesVisitaging brainambient air pollutionbrain healthbrain tissueclinical databasecognitive abilitycognitive functioncognitive performancecohortepidemiology studyfine particlesfollow-upglial activationhealth datainstrumentinterdisciplinary approachmixed dementiamodifiable riskmortalityneuropathologynovelolder menolder womenolfactory bulbparticleparticle exposurephysical conditioningpollutantprospectivescreeningsexsocioeconomicsspatiotemporalsystemic inflammatory response
项目摘要
Project Summary
1) Objectives: We will define associations and pathways through which exposure to PM2.5 and metals
contribute to dementia-associated neuropathology (DAN), incident dementia, and cognitive function. We will do
so by leveraging resources from the Adult Changes in Thought (ACT) study, an ongoing, prospective cohort
study of brain aging and dementia in older adults who are cognitively intact at enrollment. Every two years
since 1994, ACT has collected vetted data on dementia, other brain health measures, physical health, lifestyle,
medications, and residential history for over 5000 participants, following them until incident dementia or death.
At each timepoint, ACT assesses dementia using the Cognitive Abilities Screening Instrument (CASI) and
consensus diagnosis using DSM-IV criteria. AD is also assessed based on NINCDS criteria. For participants
who consent to autopsy (~25%), ACT performs a neuropathological examination of their brains, including
confirmation of dementia diagnoses. Our study will build on these data and resources to achieve 3 primary
aims: (1) to characterize PM2.5 and metal concentrations within the olfactory bulb (OB), olfactory tract (OT), and
brain tissues of ~140 human donors to establish whether the OB is a pathway through which air pollutants
reach the brain; (2) to investigate the OB as a pathway for DAN within the OBs and brains of these donors; and
(3) to assess the association of PM2.5, metals with incident dementia - including for pathologically-defined AD,
μVBI, LBD, and mixed dementia – and cognitive function, controlling for key confounders and examining effect
modification by sex, race/ethnicity, socio-economics, and health conditions and mediation by health conditions.
2) Approach: We will test our aims following a multi-disciplinary approach that relies on (1) our detailed
analysis of brains and OB for particles, metals and DAN indicators for ACT participants who consented to
autopsy and (2) our epidemiological analyses of the association of long-term ambient PM2.5 and metal
exposures with incident dementia, AD, μVBI, and LBD for the entire ACT cohort and for the subset with
neuropathology confirmed dementia diagnoses. For both, we will leverage ACT’s rich database of clinical and
functional health measures, behaviors, and residential histories. We, for example, will use the residential
histories to estimate long-term ambient PM2.5 and associated metal exposures for each ACT participant using
novel spatio-temporal models. We will also use health and behavioral data to control for key confounders and
predictors and health data to assess modification and mediation of the pollutant-dementia associations.
3) Expected Results: We will provide new evidence of the risks posed by airborne metals to incident dementia
and of the pathways through which airborne metals cause damage. In so doing, results from our study will help
identify targeted interventions to block pathways to dementia by type and mitigate the severe and growing
burden of AD and other dementias.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
JOSHUA A SONNEN其他文献
JOSHUA A SONNEN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('JOSHUA A SONNEN', 18)}}的其他基金
Pharmaconeuropathology of Brain Aging and Dementia
脑衰老和痴呆的药物神经病理学
- 批准号:
8241022 - 财政年份:2005
- 资助金额:
$ 65.84万 - 项目类别:
Pharmaconeuropathology of Brain Aging and Dementia
脑衰老和痴呆的药物神经病理学
- 批准号:
8431388 - 财政年份:2005
- 资助金额:
$ 65.84万 - 项目类别:
Pharmaconeuropathology of Brain Aging and Dementia
脑衰老和痴呆的药物神经病理学
- 批准号:
8644769 - 财政年份:2005
- 资助金额:
$ 65.84万 - 项目类别:
Pharmaconeuropathology of Brain Aging and Dementia
脑衰老和痴呆的药物神经病理学
- 批准号:
7884081 - 财政年份:2005
- 资助金额:
$ 65.84万 - 项目类别:
Pharmaconeuropathology of Brain Aging and Dementia
脑衰老和痴呆的药物神经病理学
- 批准号:
8813516 - 财政年份:2005
- 资助金额:
$ 65.84万 - 项目类别:
相似海外基金
Interplay between Aging and Tubulin Posttranslational Modifications
衰老与微管蛋白翻译后修饰之间的相互作用
- 批准号:
24K18114 - 财政年份:2024
- 资助金额:
$ 65.84万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
The Canadian Brain Health and Cognitive Impairment in Aging Knowledge Mobilization Hub: Sharing Stories of Research
加拿大大脑健康和老龄化认知障碍知识动员中心:分享研究故事
- 批准号:
498288 - 财政年份:2024
- 资助金额:
$ 65.84万 - 项目类别:
Operating Grants
EMNANDI: Advanced Characterisation and Aging of Compostable Bioplastics for Automotive Applications
EMNANDI:汽车应用可堆肥生物塑料的高级表征和老化
- 批准号:
10089306 - 财政年份:2024
- 资助金额:
$ 65.84万 - 项目类别:
Collaborative R&D
関節リウマチ患者のSuccessful Agingに向けたフレイル予防対策の構築
类风湿性关节炎患者成功老龄化的衰弱预防措施的建立
- 批准号:
23K20339 - 财政年份:2024
- 资助金额:
$ 65.84万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Baycrest Academy for Research and Education Summer Program in Aging (SPA): Strengthening research competencies, cultivating empathy, building interprofessional networks and skills, and fostering innovation among the next generation of healthcare workers t
Baycrest Academy for Research and Education Summer Program in Aging (SPA):加强研究能力,培养同理心,建立跨专业网络和技能,并促进下一代医疗保健工作者的创新
- 批准号:
498310 - 财政年份:2024
- 资助金额:
$ 65.84万 - 项目类别:
Operating Grants
Life course pathways in healthy aging and wellbeing
健康老龄化和福祉的生命历程路径
- 批准号:
2740736 - 财政年份:2024
- 资助金额:
$ 65.84万 - 项目类别:
Studentship
I-Corps: Aging in Place with Artificial Intelligence-Powered Augmented Reality
I-Corps:利用人工智能驱动的增强现实实现原地老龄化
- 批准号:
2406592 - 财政年份:2024
- 资助金额:
$ 65.84万 - 项目类别:
Standard Grant
NSF PRFB FY 2023: Connecting physiological and cellular aging to individual quality in a long-lived free-living mammal.
NSF PRFB 2023 财年:将生理和细胞衰老与长寿自由生活哺乳动物的个体质量联系起来。
- 批准号:
2305890 - 财政年份:2024
- 资助金额:
$ 65.84万 - 项目类别:
Fellowship Award
虚弱高齢者のSuccessful Agingを支える地域課題分析指標と手法の確立
建立区域问题分析指标和方法,支持体弱老年人成功老龄化
- 批准号:
23K20355 - 财政年份:2024
- 资助金额:
$ 65.84万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
「ケア期間」に着目したbiological aging指標の開発
开发聚焦“护理期”的生物衰老指数
- 批准号:
23K24782 - 财政年份:2024
- 资助金额:
$ 65.84万 - 项目类别:
Grant-in-Aid for Scientific Research (B)