Biomechanics of Lens Morphogenesis

晶状体形态发生的生物力学

• 批准号: 10718201
• 负责人: Matthew A Reilly
• 金额: $ 41.39万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10718201
• 关键词: Adult; Age; Aging; Architecture; Automobile Driving; Biomechanics; Cataract; Cell Compartmentation; Computational Technique; Crystalline Lens; Development; Economics; Elasticity; Equilibrium; Exercise; Eye; Future; Gelatin; Growth; Health; Human; Intervention; Knowledge; Length; Lens Fiber; Medical Care Costs; Modeling; Myopia; Optics; Pattern; Presbyopia; Productivity; Property; Risk Factors; Shapes; Therapeutic; Therapeutic Intervention; Time; United States; Water; age related; aged; biomechanical engineering; biomechanical test; capsule; cost; driving force; fiber cell; improved; innovation; lens; lens capsule; lens morphogenesis; novel; prevent; soft tissue; theories

Project Summary Lens shape is a primary determinant of its optical power and accommodative ability. Growth-induced change in lens shape directly causes presbyopia and is a known risk factor for age-related cataract. However, the biomechanical factors which interact to govern age-related changes in lens shape remain unknown. In the proposed study, we will systematically characterize the biomechanical properties of the aging human lens and use that information to understand how the lens shape evolves with age. A novel theory of constrained soft tissue growth will be employed to account for the presence of the lens capsule and its influence on the volumetric expansion of the lens fiber cell compartment. The biomechanical interaction between the fiber cell compartment and the capsule ultimately dictates the shape of the lens. These interactions behave like a water balloon filled with gelatin: as the gelatin sets, the properties of the gelatin contribute more and more to the shape of the balloon.

项目摘要 镜头形状是其光学能力和适应性能力的主要决定因素。生长引起的 晶状体形状的变化直接引起长老会，是与年龄相关性白内障的已知危险因素。 但是，与晶状体形状相互影响的相互影响的生物力学因子仍然存在 未知。在拟议的研究中，我们将系统地表征 老化的人镜头并使用该信息来了解镜头如何随着年龄的增长而发展。小说 将采用约束软组织生长的理论来解释镜头胶囊的存在 及其对透镜纤维细胞室的体积扩张的影响。生物力学 纤维电池室和胶囊之间的相互作用最终决定了晶状体的形状。 这些相互作用的行为就像是充满明胶的水气球：当明胶套装时， 明胶对气球的形状越来越多。