Biomechanics of Lens Morphogenesis

项目摘要 透镜的形状是决定其光学能力和调节能力的主要因素。生长诱导型 晶状体形状的改变直接导致老花眼，是与年龄相关的白内障的已知危险因素。 然而，控制与年龄相关的晶状体形状变化的生物力学因素仍然存在。 未知。在拟议的研究中，我们将系统地表征人工关节的生物力学特性。 人类晶状体的老化，并利用这些信息来了解晶状体形状如何随着年龄的变化而演变。一本小说 软组织生长受限的理论将被用来解释晶状体囊的存在。 以及它对晶状体纤维细胞室体积膨胀的影响。生物力学 纤维细胞室和囊膜之间的相互作用最终决定了晶状体的形状。 这些相互作用的行为就像一个充满明胶的水球：当明胶凝固时， 明胶对气球形状的贡献越来越大。

Project Summary Lens shape is a primary determinant of its optical power and accommodative ability. Growth-induced change in lens shape directly causes presbyopia and is a known risk factor for age-related cataract. However, the biomechanical factors which interact to govern age-related changes in lens shape remain unknown. In the proposed study, we will systematically characterize the biomechanical properties of the aging human lens and use that information to understand how the lens shape evolves with age. A novel theory of constrained soft tissue growth will be employed to account for the presence of the lens capsule and its influence on the volumetric expansion of the lens fiber cell compartment. The biomechanical interaction between the fiber cell compartment and the capsule ultimately dictates the shape of the lens. These interactions behave like a water balloon filled with gelatin: as the gelatin sets, the properties of the gelatin contribute more and more to the shape of the balloon.