International epidemiologic Database to Evaluate AIDS (West Africa) Core

评估艾滋病的国际流行病学数据库（西非）核心

• 批准号: 7684781
• 负责人: Francois Dabis
• 金额: $ 129.12万
• 依托单位: UNIVERSITY OF BORDEAUX II
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7684781
• 关键词: Acquired Immunodeficiency Syndrome; Address; Adult; Africa; Africa South of the Sahara; African; Age; Ants; Area; Caring; Child; Cities; Clinical; Collaborations; Country; Cross-Sectional Studies; Data; Data Collection; Databases; Device or Instrument Development; Epidemiology; Financial Support; France; Gender; HIV; HIV-2; Hepatitis B; Immune; Infection; International; Knowledge; Lead; Mission; Monitor; Mothers; Opportunistic Infections; Outcome; Patients; Persons; Pregnant Women; Process; Public Health; Research; Research Personnel; Sample Size; Site; Structure; Syndrome; Treatment outcome; Tuberculosis; Universities; Woman; antiretroviral therapy; base; cohort; design; expectation; experience; follow-up; improved; interest; outcome forecast; pregnant; reconstitution; response; treatment program

DESCRIPTION (provided by applicant): The WADA (West Africa Data Base on Antiretroviral Therapy) Collaboration is a unique collaboration among cohorts in West Africa with a mission to conduct hypothesis-driven epidemiological research on the prognosis and outcome of HIV type 1 and 2-infected people, including adults, pregnant mothers, and children. The research will focus on scientific questions requiring a large sample size of patients which the contributing cohorts cannot answer individually and which do not overlap with existing projects. Activities during Year 1 will focus on cross-sectional analyses of existing data, a comprehensive examination of the available data in terms of completeness of core items at baseline and during follow-up, and the development of instruments to standardize, harmonize and improve data collection across sites. The research agenda and specific hypotheses for Years 2-5 will be finalized based on the results of Year 1 activities, with a focus on the following four areas: programmatic issues (access to ant- retroviral treatment and losses to follow up); monitoring and outcomes of treatment in adults, children and pregnant women; clinical response, with a special interest for tuberculosis, opportunistic infections, immune reconstitution syndrome and hepatitis B coinfection; care of HIV-2 infection. Additional research questions will be focused in the subsequent years, with the expectation to address around 30 completed projects and analyses over five years. A total of 17 cohorts in six major cities in six West African countries - each ongoing and with their own internal governance structure and financial support - have agreed to contribute data collected already over the past years from a collective number of 2,345 HIV-infected children and 33,245 adult patients. The regional coordinating centre for this application will be located in Bordeaux, France. This university team (Prof Francois Dabis, ISPED, Universite Victor Segalen) has a long lasting experience in epidemiological HIV cohort research in West Africa, with an office in Abidjan, Cote d'lvoire. It also has extensive experience with international collaborations of this kind including the Ghent Group on HIV in Women and Children and the ART-LINC Collaboration. ISPED will be responsible for the implementation of the WADA Collaboration. Data will be collected from affiliated cohorts every year and once merged into a main WADA database, data extracts will be made for the various projects and analyses. This process will be repeated annually allowing for the analysis of the most contemporary data collected in the affiliated cohorts. WADA is an unprecedented undertaking in West Africa, with a unique design, lead by investigators with extensive experience, that will advance the public health knowledge required to better understand and treat HIV-infected persons of all ages, genders and backgrounds in sub-Saharan Africa, the continent with the largest unmet needs but with onqoing, rapid and massive roll-out of HIV treatment programmes.

描述（由申请人提供）：WADA（西非抗逆转录病毒治疗数据库）协作是西非人群之间的独特协作，其使命是对1型和2型艾滋病毒感染者（包括成人、孕妇和儿童）的预后和结果进行假设驱动的流行病学研究。该研究将侧重于需要大样本量患者的科学问题，这些问题是贡献队列无法单独回答的，并且与现有项目不重叠。第一年的活动将侧重于对现有数据进行跨部门分析，全面审查现有数据在基线和后续行动期间核心项目的完整性，并开发工具，以标准化、协调和改进各地点的数据收集。第二至第五年的研究议程和具体假设将根据第一年活动的结果最后确定，重点是以下四个领域：（获得抗逆转录病毒治疗的机会和后续行动的损失）;监测成人、儿童和孕妇的治疗情况和结果;临床反应，特别关注结核病、机会性感染、免疫重建综合征和B型肝炎合并感染; HIV-2感染的护理。其他研究问题将在随后几年集中，预计在五年内解决约30个已完成的项目和分析。西非六个国家六个主要城市的17个群组-每个群组都在进行中，并有自己的内部治理结构和财政支持-已同意提供过去几年从2 345名感染艾滋病毒的儿童和33 245名成人患者收集的数据。此项申请的区域协调中心将设在法国波尔多。这个大学团队（Francois Dabis教授，ISPED，Universite维克托Segalen）在西非流行病学HIV队列研究方面拥有长期的经验，在科特迪瓦阿比让设有办事处。它还在这类国际合作方面拥有丰富的经验，包括妇女和儿童艾滋病毒问题根特小组和ART-LINC协作。ISPED将负责世界反兴奋剂机构协作的实施。每年将从附属队列收集数据，一旦合并到世界反兴奋剂机构的主要数据库中，将为各种项目和分析提取数据。这一过程将每年重复一次，以便分析在附属队列中收集的最新数据。世界反兴奋剂机构在西非是一项前所未有的事业，其独特的设计，由具有丰富经验的调查人员领导，将促进更好地了解和治疗撒哈拉以南非洲所有年龄、性别和背景的艾滋病毒感染者所需的公共卫生知识。